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Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin

JOURNAL OF ALZHEIMERS DISEASE (2018)

期刊

JOURNAL OF ALZHEIMERS DISEASE

卷 62, 期 3, 页码 1113-1123

出版社

IOS PRESS

DOI: 10.3233/JAD-170584

关键词

Biomarkers; cerebrospinal fluid; frontotemporal lobar degeneration; neuroimaging; transcranial magnetic stimulation

类别

Neurosciences

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Reagent

摘要

Frontotemporal dementia (FTD) is a heterogeneous clinical, genetic, and neuropathological disorder. Clinical diagnosis and prediction of neuropathological substrates are hampered by heterogeneous pictures. Diagnostic markers are key in clinical trials to differentiate FTD from other neurodegenerative dementias. In the same view, identifying the neuropathological hallmarks of the disease is key in light of future disease-modifying treatments. The aim of the present review is to unravel the progress in biomarker discovery, discussing the potential applications of available biological, imaging, and neurophysiological markers.

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