Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

(2018) Anubha Mahajan et al.   NATURE GENETICS

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

(2018) Soren K. Thomsen et al.   NATURE GENETICS

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

(2018) Matthias Thurner et al.   eLife

Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes

(2017) So Yoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Genetic regulatory signatures underlying islet gene expression and type 2 diabetes

(2017) Arushi Varshney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants

(2016) Soren K. Thomsen et al.   DIABETES

Increased Expression of the Diabetes GeneSOX4Reduces Insulin Secretion by Impaired Fusion Pore Expansion

(2016) Stephan C. Collins et al.   DIABETES

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants

(2016) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics

(2016) David Lamparter et al.   PLoS Computational Biology

Defective Wnt Signaling: A Potential Contributor to Cardiometabolic Disease?: Figure 1

(2015) Amy C. Arnold et al.   DIABETES

Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals

(2015) Ghadi Antoun et al.   DIABETOLOGIA

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

(2015) Kyle J Gaulton et al.   NATURE GENETICS

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

(2015) Martijn van de Bunt et al.   PLoS Genetics

Guilt by rewiring: gene prioritization through network rewiring in Genome Wide Association Studies

(2014) L. Hou et al.   HUMAN MOLECULAR GENETICS

Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment

(2014) Jim R Hughes et al.   NATURE GENETICS

Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes

(2014) Valgerdur Steinthorsdottir et al.   NATURE GENETICS

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

(2014) Alicia Lundby et al.   NATURE METHODS

The pancreatic β cell: recent insights from human genetics

(2014) Soren K. Thomsen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins

(2014) Wei Yuan et al.   Nature Communications

Glucose homeostasis, obesity and diabetes

(2013) Gul Bano   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

(2013) Antigone S. Dimas et al.   DIABETES

14-3-3 proteins are essential signalling hubs for beta cell survival

(2013) G. E. Lim et al.   DIABETOLOGIA

Evaluating empirical bounds on complex disease genetic architecture

(2013) Vineeta Agarwala et al.   NATURE GENETICS

The Reactome pathway knowledgebase

(2013) David Croft et al.   NUCLEIC ACIDS RESEARCH

Reconstructing targetable pathways in lung cancer by integrating diverse omics data

(2013) O. Alejandro Balbin et al.   Nature Communications

GENCODE: The reference human genome annotation for The ENCODE Project

(2012) J. Harrow et al.   GENOME RESEARCH

Deletion of GαZProtein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass

(2012) Michelle E. Kimple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

SteinerNet: a web server for integrating 'omic' data to discover hidden components of response pathways

(2012) N. Tuncbag et al.   NUCLEIC ACIDS RESEARCH

Reciprocal Metabolic Perturbations in the Adipose Tissue and Liver of GPIHBP1-Deficient Mice

(2011) Michael M. Weinstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Construction and analysis of the protein-protein interaction networks for schizophrenia, bipolar disorder, and major depression

(2011) Sheng-An Lee et al.   BMC BIOINFORMATICS

Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology

(2011) Elizabeth J. Rossin et al.   PLoS Genetics

Mitochondrial dysfunction in insulin insensitivity: implication of mitochondrial role in type 2 diabetes

(2010) Chih-Hao Wang et al.   Annals of the New York Academy of Sciences

Homozygous Mutations in NEUROD1 Are Responsible for a Novel Syndrome of Permanent Neonatal Diabetes and Neurological Abnormalities

(2010) O. Rubio-Cabezas et al.   DIABETES

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Genomics, Type 2 Diabetes, and Obesity

(2010) Mark I. McCarthy   NEW ENGLAND JOURNAL OF MEDICINE

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Walking the Interactome for Prioritization of Candidate Disease Genes

(2008) Sebastian Köhler et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identifying functional modules in protein-protein interaction networks: an integrated exact approach

(2008) M. T. Dittrich et al.   BIOINFORMATICS