14-3-3 proteins are essential signalling hubs for beta cell survival

Bcl-2 and Bcl-x L Suppress Glucose Signaling in Pancreatic β-Cells

(2012) Dan S. Luciani et al.   DIABETES

Control of pancreatic β-cell fate by insulin signaling: The sweet spot hypothesis

(2011) James D Johnson et al.   CELL CYCLE

Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription

(2011) Emilyn U. Alejandro et al.   FASEB JOURNAL

Cytokines Tumor Necrosis Factor-α and Interferon-γ Induce Pancreatic β-Cell Apoptosis through STAT1-mediated Bim Protein Activation

(2011) Jenny Barthson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

14-3-3 proteins as potential therapeutic targets

(2011) Jing Zhao et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Kinetics and genomic profiling of adult human and mouse β-cell maturation

(2011) Marta Szabat et al.   Islets

Acute Insulin Signaling in Pancreatic Beta-Cells Is Mediated by Multiple Raf-1 Dependent Pathways

(2010) Emilyn U. Alejandro et al.   ENDOCRINOLOGY

Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis

(2010) Mercedes Pozuelo-Rubio   FEBS Journal

p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress

(2010) Esteban N. Gurzov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

(2009) E N Gurzov et al.   CELL DEATH AND DIFFERENTIATION

PUMA is directly activated by NF-κB and contributes to TNF-α-induced apoptosis

(2009) P Wang et al.   CELL DEATH AND DIFFERENTIATION

Bad News for  -Cell Apoptosis

(2009) H. E. Thomas et al.   DIABETES

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in  -Cells

(2009) L. G. Grunnet et al.   DIABETES

Current Advances and Travails in Islet Transplantation

(2009) D. M. Harlan et al.   DIABETES

Identification of Novelin VivoPhosphorylation Sites of the Human Proapoptotic Protein BAD

(2009) Lisa Polzien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a β-Arrestin 1-mediated ERK1/2 Activation in Pancreatic β-Cells

(2009) Julie Quoyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

14-3-3:Shc Scaffolds Integrate Phosphoserine and Phosphotyrosine Signaling to Regulate Phosphatidylinositol 3-Kinase Activation and Cell Survival

(2009) Emma F. Barry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoform-specific cleavage of 14-3-3 proteins in apoptotic JURL-MK1 cells

(2009) Kateřina Kuželová et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Serine 58 of 14-3-3  Is a Molecular Switch Regulating ASK1 and Oxidant Stress-Induced Cell Death

(2009) J. Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart

(2009) J. D. Scott et al.   SCIENCE

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic β-cells

(2008) Elida Lai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cytokine-Induced  -Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

(2008) M. C. Akerfeldt et al.   DIABETES

Insulin Stimulates Primary β-Cell Proliferation via Raf-1 Kinase

(2008) Jennifer L. Beith et al.   ENDOCRINOLOGY

Maturation of Adult β-Cells Revealed Using aPdx1/InsulinDual-Reporter Lentivirus

(2008) Marta Szabat et al.   ENDOCRINOLOGY

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

(2008) Nika N Danial et al.   NATURE MEDICINE

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

(2008) Deborah K. Morrison   TRENDS IN CELL BIOLOGY