Suppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

(2018) Ling Li et al.   BIOMATERIALS

Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks

(2018) Eva K. Brinkman et al.   MOLECULAR CELL

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

(2018) Michael Kosicki et al.   NATURE BIOTECHNOLOGY

Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells

(2018) Stephan Riesenberg et al.   Nature Communications

One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors

(2018) Maren Schiwon et al.   Molecular Therapy-Nucleic Acids

Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours

(2018) Bumwhee Lee et al.   Nature Biomedical Engineering

In vivo CRISPR editing with no detectable genome-wide off-target mutations

(2018) Pinar Akcakaya et al.   NATURE

Inhibition of HBV Expression in HBV Transgenic Mice Using AAV-Delivered CRISPR-SaCas9

(2018) Hao Li et al.   Frontiers in Immunology

High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population

(2018) Dimitrios L. Wagner et al.   NATURE MEDICINE

Hepatitis B cure: From discovery to regulatory approval

(2017) Anna S. Lok et al.   HEPATOLOGY

CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level

(2017) Garmen Yuen et al.   NUCLEIC ACIDS RESEARCH

A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis

(2017) Markus Löbrich et al.   TRENDS IN BIOCHEMICAL SCIENCES

RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells

(2017) Harry O. King et al.   Stem Cell Reports

Dramatic Improvement of CRISPR/Cas9 Editing in Candida albicans by Increased Single Guide RNA Expression

(2017) Henry Ng et al.   mSphere

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells

(2016) Ciaran M Lee et al.   MOLECULAR THERAPY

Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA

(2016) Christoph Seeger et al.   MOLECULAR THERAPY

Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome

(2016) Maximilian Müller et al.   MOLECULAR THERAPY

A multifunctional AAV–CRISPR–Cas9 and its host response

(2016) Wei Leong Chew et al.   NATURE METHODS

Distinct patterns of Cas9 mismatch tolerancein vitroandin vivo

(2016) Becky X.H. Fu et al.   NUCLEIC ACIDS RESEARCH

Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining

(2016) Guangqing Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells

(2015) Chen Yu et al.   Cell Stem Cell

Cell cycle regulation of human DNA repair and chromatin remodeling genes

(2015) Robin Mjelle et al.   DNA REPAIR

The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2

(2015) Maciej Stępnik et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

(2015) Michael Nassal   GUT

Systematic analysis of CRISPR–Cas9 mismatch tolerance reveals low levels of off-target activity

(2015) Emily M. Anderson et al.   JOURNAL OF BIOTECHNOLOGY

Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013

(2015) Aparna Schweitzer et al.   LANCET

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma

(2015) Erika A. Newman et al.   MOLECULAR CANCER RESEARCH

The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo[def,p]chrysene on human hepatocellular cancer cell line HepG2

(2015) Sylwia Spryszyńska et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

Rationally engineered Cas9 nucleases with improved specificity

(2015) I. M. Slaymaker et al.   SCIENCE

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease

(2015) Edward M. Kennedy et al.   VIROLOGY

Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication

(2015) Jie Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Homology and enzymatic requirements of microhomology-dependent alternative end joining

(2015) S Sharma et al.   Cell Death & Disease

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

(2015) Vyas Ramanan et al.   Scientific Reports

Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing

(2015) Francis Robert et al.   Genome Medicine

DNA double-strand break repair pathway choice and cancer

(2014) Tomas Aparicio et al.   DNA REPAIR

Molecular Virology of Hepatitis B Virus and Targets for Antiviral Intervention

(2014) Dieter Glebe et al.   INTERVIROLOGY

A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts

(2014) Fei Huang et al.   PLoS One

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo

(2014) Su-Ru Lin et al.   Molecular Therapy-Nucleic Acids

Targeting Hepatitis B Virus With CRISPR/Cas9

(2014) Christoph Seeger et al.   Molecular Therapy-Nucleic Acids

DNA DSB repair pathway choice: an orchestrated handover mechanism

(2013) A Kakarougkas et al.   BRITISH JOURNAL OF RADIOLOGY

In VitroMorphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes ofCurcuma zedoaria

(2013) Syarifah Nur Syed Abdul Rahman et al.   Evidence-based Complementary and Alternative Medicine

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The Molecular Virology of Hepatitis B Virus

(2013) Corinna Bremer et al.   SEMINARS IN LIVER DISEASE

Repair of Strand Breaks by Homologous Recombination

(2013) M. Jasin et al.   Cold Spring Harbor Perspectives in Biology

Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening

(2011) Fei Huang et al.   ACS Chemical Biology

Association between nasal shedding and fever that influenza A (H3N2) induces in dogs

(2011) Daesub Song et al.   Virology Journal

Collaboration and competition between DNA double-strand break repair pathways

(2010) Elizabeth M. Kass et al.   FEBS LETTERS