标题
Hepatitis B cure: From discovery to regulatory approval
作者
关键词
-
出版物
HEPATOLOGY
Volume 66, Issue 4, Pages 1296-1313
出版商
Wiley
发表日期
2017-08-01
DOI
10.1002/hep.29323
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Nested case-control study: hepatocellular carcinoma risk after hepatitis B surface antigen seroclearance
- (2016) P. P. Gounder et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant
- (2016) William S. Mason et al. GASTROENTEROLOGY
- Hepatitis B Virus–Specific and Global T-Cell Dysfunction in Chronic Hepatitis B
- (2016) Jang-June Park et al. GASTROENTEROLOGY
- Combination of Tenofovir Disoproxil Fumarate and Peginterferon α-2a Increases Loss of Hepatitis B Surface Antigen in Patients With Chronic Hepatitis B
- (2016) Patrick Marcellin et al. GASTROENTEROLOGY
- Serum Levels of Hepatitis B Surface Antigen and DNA Can Predict Inactive Carriers With Low Risk of Disease Progression
- (2016) Jessica Liu et al. HEPATOLOGY
- Discontinuation of oral antivirals in chronic hepatitis B: A systematic review
- (2016) George Papatheodoridis et al. HEPATOLOGY
- Noninvasive Tests for Fibrosis Predict 5-Year Mortality and Hepatocellular Carcinoma in Patients With Chronic Hepatitis B
- (2016) Jeong Han Kim et al. JOURNAL OF CLINICAL GASTROENTEROLOGY
- Randomized phase II study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B
- (2016) Anna S. Lok et al. JOURNAL OF HEPATOLOGY
- Differential Reductions in Viral Antigens Expressed from CCCDNAVS Integrated DNA in Treatment Naïve HBEAG Positive and Negative Patients with Chronic HBV after RNA Interference Therapy with ARC-520
- (2016) M.-F. Yuen et al. JOURNAL OF HEPATOLOGY
- First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B
- (2016) Antje Blank et al. JOURNAL OF HEPATOLOGY
- NVR 3-778, a First-in-Class HBV Core Inhibitor, Alone and in Combination with Peg-Interferon (PegIFN), in Treatment-Naive HBeAg-Positive Patients: Early Reductions in HBV DNA and HBeAg
- (2016) M.-F. Yuen et al. JOURNAL OF HEPATOLOGY
- Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound
- (2016) Jie Wang et al. JOURNAL OF HEPATOLOGY
- PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy
- (2016) George Papatheodoridis et al. JOURNAL OF HEPATOLOGY
- Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket
- (2016) Balasubramanian Venkatakrishnan et al. JOURNAL OF VIROLOGY
- Progress With Developing Use of Gene Editing To Cure Chronic Infection With Hepatitis B Virus
- (2016) Abdullah Ely et al. MOLECULAR THERAPY
- Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA
- (2016) Christoph Seeger et al. MOLECULAR THERAPY
- Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor
- (2016) Adrien Decorsière et al. NATURE
- Fulminant Myocarditis with Combination Immune Checkpoint Blockade
- (2016) Douglas B. Johnson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg+ Chronic Hepatitis B Infection
- (2016) Mamun Al-Mahtab et al. PLoS One
- Antiviral Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the Woodchuck Model of Chronic Hepatitis B
- (2016) Kyle E. Korolowicz et al. PLoS One
- Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent
- (2015) Robert G. Gish et al. ANTIVIRAL RESEARCH
- Predictors of hepatitis B e antigen-negative hepatitis in chronic hepatitis B virus-infected patients from childhood to adulthood
- (2015) Jia-Feng Wu et al. HEPATOLOGY
- AASLD guidelines for treatment of chronic hepatitis B
- (2015) Norah A. Terrault et al. HEPATOLOGY
- Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update
- (2015) S. K. Sarin et al. Hepatology International
- The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus
- (2015) Seiichi Sato et al. IMMUNITY
- Preventing Hepatitis B Reactivation Due to Immunosuppressive Drug Treatments
- (2015) Robert P. Perrillo et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Clinical outcomes and predictors for relapse after cessation of oral antiviral treatment in chronic hepatitis B patients
- (2015) Kyu Sik Jung et al. JOURNAL OF GASTROENTEROLOGY
- The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection
- (2015) Edward J. Gane et al. JOURNAL OF HEPATOLOGY
- Incidence of hepatocellular carcinoma after HBsAg seroclearance in chronic hepatitis B patients: A need for surveillance
- (2015) Gi-Ae Kim et al. JOURNAL OF HEPATOLOGY
- Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B
- (2015) Stephan Menne et al. JOURNAL OF HEPATOLOGY
- High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein
- (2015) Klaus Klumpp et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation
- (2015) Philipp Tropberger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Trained immunity in newborn infants of HBV-infected mothers
- (2015) Michelle Hong et al. Nature Communications
- Immune Response in Hepatitis B Virus Infection
- (2015) Anthony Tan et al. Cold Spring Harbor Perspectives in Medicine
- EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection
- (2015) JOURNAL OF HEPATOLOGY
- STING Agonists Induce an Innate Antiviral Immune Response against Hepatitis B Virus
- (2014) Fang Guo et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The immune tolerant phase of chronic HBV infection: new perspectives on an old concept
- (2014) Antonio Bertoletti et al. Cellular & Molecular Immunology
- Strategies to Inhibit Entry of HBV and HDV Into Hepatocytes
- (2014) Stephan Urban et al. GASTROENTEROLOGY
- Effects of Tenofovir Disoproxil Fumarate in Hepatitis B e Antigen-Positive Patients With Normal Levels of Alanine Aminotransferase and High Levels of Hepatitis B Virus DNA
- (2014) Henry L.Y. Chan et al. GASTROENTEROLOGY
- Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors
- (2014) Florian van Bömmel et al. HEPATOLOGY
- Clinical significance of circulating miR-122 in patients with dual chronic hepatitis B and C virus infection
- (2014) Huei-Ru Cheng et al. Hepatology International
- Analysis of Hepatitis B Virus Intrahepatic Covalently Closed Circular DNA and Serum Viral Markers in Treatment-Naive Patients with Acute and Chronic HBV Infection
- (2014) Weijie Li et al. PLoS One
- Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA
- (2014) J. Lucifora et al. SCIENCE
- Safety, tolerability and immunogenicity of GS-4774, a hepatitis B virus-specific therapeutic vaccine, in healthy subjects: A randomized study
- (2014) Anuj Gaggar et al. VACCINE
- Enhancing Virus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1 Blockade in Chronic Hepadnaviral Infection
- (2014) Jia Liu et al. PLoS Pathogens
- Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus
- (2013) V. de Lédinghen et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Management of Hepatitis B: Our Practice and How It Relates to the Guidelines
- (2013) Suna Yapali et al. Clinical Gastroenterology and Hepatology
- GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees
- (2013) Robert E. Lanford et al. GASTROENTEROLOGY
- HBsAg seroclearance after nucleoside analogue therapy in patients with chronic hepatitis B: clinical outcomes and durability
- (2013) Gi-Ae Kim et al. GUT
- Prediction models of long-term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles
- (2013) Mei-Hsuan Lee et al. HEPATOLOGY
- Reduction of hepatitis B surface antigen levels and hepatitis B surface antigen seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy
- (2013) Wai-Kay Seto et al. HEPATOLOGY
- Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes
- (2013) Fei Liu et al. PLoS Pathogens
- High Levels of Hepatitis B Surface Antigen Increase Risk of Hepatocellular Carcinoma in Patients With Low HBV Load
- (2012) Tai–Chung Tseng et al. GASTROENTEROLOGY
- Preserved T-Cell Function in Children and Young Adults With Immune-Tolerant Chronic Hepatitis B
- (2012) Patrick T.F. Kennedy et al. GASTROENTEROLOGY
- Restored Function of HBV-Specific T Cells After Long-term Effective Therapy With Nucleos(t)ide Analogues
- (2012) Carolina Boni et al. GASTROENTEROLOGY
- Prevention of hepatitis B virus-related hepatocellular carcinoma with antiviral therapy
- (2012) Ching-Lung Lai et al. HEPATOLOGY
- IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
- (2012) Laura Belloni et al. JOURNAL OF CLINICAL INVESTIGATION
- Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study
- (2012) Patrick Marcellin et al. LANCET
- Prediction of Liver-Related Events Using Fibroscan in Chronic Hepatitis B Patients Showing Advanced Liver Fibrosis
- (2012) Seung Up Kim et al. PLoS One
- PD-1 Blockage Reverses Immune Dysfunction and Hepatitis B Viral Persistence in a Mouse Animal Model
- (2012) Horng-Tay Tzeng et al. PLoS One
- Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection
- (2011) Antonio Bertoletti et al. GUT
- Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score
- (2011) Hwai-I Yang et al. LANCET ONCOLOGY
- Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B
- (2010) Ting-Tsung Chang et al. HEPATOLOGY
- Serum hepatitis B surface antigen and hepatitis B e antigen titers: Disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers
- (2010) Alexander J.V. Thompson et al. HEPATOLOGY
- Risk assessment of hepatitis B virus-related hepatocellular carcinoma development using liver stiffness measurement (FibroScan)
- (2010) Kyu Sik Jung et al. HEPATOLOGY
- Nomograms for Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B Virus Infection
- (2010) Hwai-I Yang et al. JOURNAL OF CLINICAL ONCOLOGY
- Hepatitis B surface antigen: Relation to hepatitis B replication parameters in HBeAg-negative chronic hepatitis B
- (2010) Emanuel K. Manesis et al. JOURNAL OF HEPATOLOGY
- Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis B
- (2009) Paola Fisicaro et al. GASTROENTEROLOGY
- Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography
- (2009) Ryota Masuzaki et al. HEPATOLOGY
- HBsAg Seroclearance in Chronic Hepatitis B in Asian Patients: Replicative Level and Risk of Hepatocellular Carcinoma
- (2008) Man–Fung Yuen et al. GASTROENTEROLOGY
- Sustained HBeAg and HBsAg Loss After Long-term Follow-up of HBeAg-Positive Patients Treated With Peginterferon α-2b
- (2008) Erik H.C.J. Buster et al. GASTROENTEROLOGY
- Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B
- (2008) Man-Fung Yuen et al. JOURNAL OF HEPATOLOGY
- Correlation between serum hepatitis B virus core-related antigen and intrahepatic covalently closed circular DNA in chronic hepatitis B patients
- (2008) Fumitaka Suzuki et al. JOURNAL OF MEDICAL VIROLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started