Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties

Co-administration of Antimicrobial Peptides Enhances Toll-like Receptor 4 Antagonist Activity of a Synthetic Glycolipid

(2018) Fabio A. Facchini et al.   ChemMedChem

Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents

(2018) Yao Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances on Toll-like receptor 4 modulation: new therapeutic perspectives

(2018) Lenny Zaffaroni et al.   Future Medicinal Chemistry

Structure–Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists

(2018) Fabio A. Facchini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dry Thermotropic Glycolipid Self-Assembly:A Review

(2018) Rauzah Hashim et al.   Journal of Oleo Science

Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

(2017) Je-Kyung Ryu et al.   IMMUNITY

Amphiphilic Guanidinocalixarenes Inhibit Lipopolysaccharide (LPS)- and Lectin-Stimulated Toll-like Receptor 4 (TLR4) Signaling

(2017) Stefania E. Sestito et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glycolipid-based nanostructures with thermal-phase transition behavior functioning as solubilizers and refolding accelerators for protein aggregates

(2017) N. Kameta et al.   Soft Matter

TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells and protects mice from lethal influenza infection

(2017) Laure Perrin-Cocon et al.   Scientific Reports

Glycolipid-based TLR4 Modulators and Fluorescent Probes: Rational Design, Synthesis, and Biological Properties

(2016) Carlotta Ciaramelli et al.   Chemical Biology & Drug Design

Self-Assembly Mechanism of pH-Responsive Glycolipids: Micelles, Fibers, Vesicles, and Bilayers

(2016) Niki Baccile et al.   LANGMUIR

Novel strategies for targeting innate immune responses to influenza

(2016) K A Shirey et al.   Mucosal Immunology

Mannoside Glycolipid Conjugates Display Anti-inflammatory Activity by Inhibition of Toll-like Receptor-4 Mediated Cell Activation

(2015) Vincent Flacher et al.   ACS Chemical Biology

CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance

(2015) Rajesh Rajaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidation of the MD-2/TLR4 Interface Required for Signaling by Lipid IVa

(2014) C. Walsh et al.   JOURNAL OF IMMUNOLOGY

Modulation of CD14 and TLR4⋅MD-2 Activities by a Synthetic Lipid A Mimetic

(2013) Roberto Cighetti et al.   CHEMBIOCHEM

TLR2 and TLR4 in Autoimmune Diseases: a Comprehensive Review

(2013) Yu Liu et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Toll-like Receptor 4 (TLR4) Modulation by Synthetic and Natural Compounds: An Update

(2013) Francesco Peri et al.   JOURNAL OF MEDICINAL CHEMISTRY

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

The Crystal Structure of Human Soluble CD14 Reveals a Bent Solenoid with a Hydrophobic Amino-Terminal Pocket

(2012) S. L. Kelley et al.   JOURNAL OF IMMUNOLOGY

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists

(2011) Francesco Peri et al.   BIOTECHNOLOGY ADVANCES

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin

(2009) Nuša Resman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Synthesis ofRubrivivax gelatinosusLipid A and Analogues for Investigation of the Structural Basis for Immunostimulating and Inhibitory Activities

(2008) Yoshiyuki Fukase et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Taxanes inhibit human TLR4 signaling by binding to MD-2

(2008) Nuša Resman et al.   FEBS LETTERS