Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists
出版年份 2019 全文链接
标题
Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists
作者
关键词
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出版物
Science Signaling
Volume 12, Issue 574, Pages eaau8072
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2019-03-27
DOI
10.1126/scisignal.aau8072
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Oliceridine (TRV130), a Novel G Protein-Biased Ligand at the μ-Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. I: Development of a Pharmacokinetic/Pharmacodynamic Model
- (2018) Michael J. Fossler et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Pain Therapy Guided by Purpose and Perspective in Light of the Opioid Epidemic
- (2018) Amie L. Severino et al. Frontiers in Psychiatry
- A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
- (2018) Huiping Ding et al. Science Translational Medicine
- Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents
- (2017) Ahmad A Altarifi et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Usefulness for the combination of G protein- and β-arrestin-biased ligands of μ-opioid receptors: Prevention of antinociceptive tolerance
- (2017) Tomohisa Mori et al. Molecular Pain
- Cebranopadol, a novel first-in-class analgesic drug candidate
- (2017) Annette Christoph et al. PAIN
- Biased Opioid Receptor Ligands: Gain without Pain
- (2017) Ravi Ranjan et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Antihyperalgesic, Antiallodynic, and Antinociceptive Effects of Cebranopadol, a Novel Potent Nociceptin/Orphanin FQ and Opioid Receptor Agonist, after Peripheral and Central Administration in Rodent Models of Neuropathic Pain
- (2017) Thomas M. Tzschentke et al. Pain Practice
- A randomized, Phase IIb study investigating oliceridine (TRV130), a novel µ-receptor G-protein pathway selective (µ-GPS) modulator, for the management of moderate to severe acute pain following abdominoplasty
- (2017) Neil Singla et al. Journal of Pain Research
- In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations
- (2016) Federica Ferrari et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility
- (2016) Nurulain T. Zaveri JOURNAL OF MEDICINAL CHEMISTRY
- Identification of Phosphorylation Sites Regulating sst3Somatostatin Receptor Trafficking
- (2016) Andreas Lehmann et al. MOLECULAR ENDOCRINOLOGY
- Research Resource: Real-Time Analysis of Somatostatin and Dopamine Receptor Signaling in Pituitary Cells Using a Fluorescence-Based Membrane Potential Assay
- (2016) Thomas Günther et al. MOLECULAR ENDOCRINOLOGY
- 2016 update of the PRIDE database and its related tools
- (2016) Juan Antonio Vizcaíno et al. NUCLEIC ACIDS RESEARCH
- A randomized, phase 2 study investigating TRV130, a biased ligand of the μ-opioid receptor, for the intravenous treatment of acute pain
- (2016) Eugene R. Viscusi et al. PAIN
- A key role for the N/OFQ-NOP receptor system in modulating nicotine taking in a model of nicotine and alcohol co-administration
- (2016) Andrea Cippitelli et al. Scientific Reports
- Cardiac β2-Adrenergic Receptor Phosphorylation at Ser355/356 Regulates Receptor Internalization and Functional Resensitization
- (2016) Xiaofang Fan et al. PLoS One
- Novel Synthesis and Pharmacological Characterization of NOP Receptor Agonist 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198)
- (2015) Steven D. Chang et al. ACS Chemical Neuroscience
- Phosphoproteomic analysis of the mouse brain mu-opioid (MOP) receptor
- (2015) Lionel Moulédous et al. FEBS LETTERS
- Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization
- (2015) Akihiko Ozawa et al. JOURNAL OF NEUROSCIENCE
- Nociceptin and the nociceptin receptor in learning and memory
- (2015) Raül Andero PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Loss of Morphine Reward and Dependence in Mice Lacking G Protein–Coupled Receptor Kinase 5
- (2014) Laura Glück et al. BIOLOGICAL PSYCHIATRY
- Different mechanisms of homologous and heterologous μ-opioid receptor phosphorylation
- (2014) Anika Mann et al. BRITISH JOURNAL OF PHARMACOLOGY
- Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers
- (2014) David G. Soergel et al. PAIN
- Biased ligands at G-protein-coupled receptors: promise and progress
- (2014) Jonathan D. Violin et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Opioid receptor desensitization: mechanisms and its link to tolerance
- (2014) Stéphane Allouche et al. Frontiers in Pharmacology
- Heterologous regulation of agonist-independent μ-opioid receptor phosphorylation by protein kinase C
- (2013) Susann Illing et al. BRITISH JOURNAL OF PHARMACOLOGY
- Advances in Analysis of Low Signal-to-Noise Images Link Dynamin and AP2 to the Functions of an Endocytic Checkpoint
- (2013) François Aguet et al. DEVELOPMENTAL CELL
- Phosphorylation of Threonine 333 Regulates Trafficking of the Human sst5Somatostatin Receptor
- (2013) Aline Petrich et al. MOLECULAR ENDOCRINOLOGY
- Deciphering µ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells
- (2012) Christian Doll et al. BRITISH JOURNAL OF PHARMACOLOGY
- Serine 363 Is Required for Nociceptin/Orphanin FQ Opioid Receptor (NOPR) Desensitization, Internalization, and Arrestin Signaling
- (2012) Nancy R. Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GRK2 Protein-mediated Transphosphorylation Contributes to Loss of Function of μ-Opioid Receptors Induced by Neuropeptide FF (NPFF2) Receptors
- (2012) Lionel Moulédous et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Transplantable Phosphorylation Probe for Direct Assessment of G Protein-Coupled Receptor Activation
- (2012) Andrea Kliewer et al. PLoS One
- Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies
- (2011) Christian Doll et al. BRITISH JOURNAL OF PHARMACOLOGY
- Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons
- (2011) Vu C Dang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pasireotide and Octreotide Stimulate Distinct Patterns of sst2ASomatostatin Receptor Phosphorylation
- (2010) Florian Pöll et al. MOLECULAR ENDOCRINOLOGY
- The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys
- (2010) Christopher A. Podlesnik et al. PSYCHOPHARMACOLOGY
- Kinase cascades and ligand-directed signaling at the kappa opioid receptor
- (2010) Michael R. Bruchas et al. PSYCHOPHARMACOLOGY
- Nociceptin/Orphanin FQ Receptor Activation Attenuates Antinociception Induced by Mixed Nociceptin/Orphanin FQ/ -Opioid Receptor Agonists
- (2009) T. V. Khroyan et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Comparison of the Antinociceptive and Antirewarding Profiles of Novel Bifunctional Nociceptin Receptor/ -Opioid Receptor Ligands: Implications for Therapeutic Applications
- (2009) L. Toll et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Nocistatin and nociceptin given centrally induce opioid-mediated gastric mucosal protection
- (2008) Zoltán S. Zádori et al. PEPTIDES
- Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: Comparison to morphine
- (2007) David Reiss et al. EUROPEAN JOURNAL OF PHARMACOLOGY
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