Review
Biochemistry & Molecular Biology
Sofie Eline Tollefsen, Ole Solheim, Patricia Mjones, Sverre Helge Torp
Summary: Meningioma is a common brain tumor without approved specific drugs. This study aims to compile the current insights of somatostatin analogs for treating patients with meningioma. A systematic search was conducted, and 17 eligible studies were evaluated. Although the efficacy of somatostatin analogs remains unclear, some studies suggest that they may be a last-option treatment for severely ill-patients. However, a controlled study or randomized clinical trial is needed to establish their efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jessica Amaru, Federica Barbieri, Marica Arvigo, Agnese Solari, Adriana Bajetto, Federica Nista, Claudia Campana, Gabriele Gaggero, Alessandro Prior, Diego Criminelli Rossi, Gianluigi Zona, Diego Ferone, Tullio Florio, Federico Gatto
Summary: The first-generation somatostatin receptor ligands (fg-SRLs), like octreotide, and the second-generation ligand, pasireotide, act mainly through SST2 in somatotroph tumor cells, and their combination does not show any additional benefits.
Article
Oncology
Laura Streit, Sophie Moog, Sylvain Hugel, Marion Rame, Emeline Tanguy, Virginie Andry, Herbert A. Schmid, Laurent Brunaud, Florence Bihain, Claire Nomine-Criqui, Yannick Goumon, Stephanie Lacomme, Sandra Lomazzi, Michel Vix, Didier Mutter, Nicolas Vitale, Stephane Ory, Stephane Gasman
Summary: NETs like pheochromocytoma can cause severe symptoms and life-threatening conditions. Treatment with somatostatin analogues may help inhibit the secretion of catecholamines. The study found that SOM230 could effectively inhibit catecholamine secretion and be considered a potential anti-secretory treatment for patients with pheochromocytoma.
Review
Biochemistry & Molecular Biology
Olesja Rogoza, Kaspars Megnis, Marija Kudrjavceva, Aija Gerina-Berzina, Vita Rovite
Summary: Somatostatin receptors play a crucial role in the treatment of neuroendocrine tumors, delaying tumor progression and regulating hormone overproduction. The expression level of SSTRs has predictive value in therapeutic response and patient survival rate. Future research will focus on other epigenetic regulators affecting somatostatin signaling and combination therapy strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonio Bianchi, Antonella Giampietro, Alfredo Pontecorvi, Gerald Raverot, Laura De Marinis
Summary: This review provides an overview of the second-line therapies for acromegaly, summarizing the evidence on clinical, molecular, and morphological aspects that can predict the response to these treatments and advocating for a patient-tailored therapeutic approach in clinical practice.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Heather S. Carr, Jeffrey T. Chang, Jeffrey A. Frost
Summary: The study identified 10 additional PDZ domain proteins that interact with SST2, and further investigated SYNJ2BP. The results showed that SYNJ2BP interacts with SST2 in an agonist-dependent manner, enhancing receptor internalization and regulating downstream signaling.
Article
Oncology
Sebastian Gulde, Tobias Wiedemann, Mathias Schillmaier, Isabel Valenca, Amelie Lupp, Katja Steiger, Hsi-Yu Yen, Stephen Baeuerle, Johannes Notni, Raul Luque, Herbert Schmid, Stefan Schulz, Donna P. Ankerst, Franz Schilling, Natalia S. Pellegata
Summary: There is currently a lack of effective medical therapy for residual/recurrent nonfunctioning pituitary tumors (NFPTs). Pasireotide may be an effective treatment, especially for female NFPTs patients. Female NFPTs patients have higher levels of Sstr3 expression, which may also be present in human NFPTs patients.
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonella Giampietro, Federica Mirra, Federico Donfrancesco, Tommaso Tartaglione, Pier Paolo Mattogno, Flavia Angelini, Lauretti Liverana, Marco Gessi, Anile Carmelo, Guido Rindi, Andrea Giustina, Maria Fleseriu, Alfredo Pontecorvi, Laura De Marinis, Antonio Bianchi
Summary: The study investigated predictors of response to Pegvisomant and Pasireotide LAR in acromegaly patients, finding that factors such as tumor extension, Ki67-Li levels, and IGF-I levels may impact treatment efficacy.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biology
Sebastian Fritzwanker, Falko Nagel, Andrea Kliewer, Viviane Stammer, Stefan Schulz
Summary: Phosphorylation of receptors is unstable during routine immunohistochemical procedures, requiring the use of phosphatase inhibitors for specific GPCR antibodies. We showed that phosphorylation of receptors is highly unstable during routine immunohistochemical procedures, and the use of phosphatase inhibitors is necessary for specific GPCR antibodies. Our findings were confirmed using phosphorylation state-specific MOP and CB1 antibodies.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
Adriana Albani, Luis Gustavo Perez-Rivas, Sicheng Tang, Julia Simon, Kristin Elisabeth Lucia, Paula Colon-Bolea, Jochen Schopohl, Sigrun Roeber, Michael Buchfelder, Roman Rotermund, Joerg Flitsch, Jun Thorsteinsdottir, Jochen Herms, Guenter Stalla, Martin Reincke, Marily Theodoropoulou
Summary: Cushing's disease is a rare and difficult to manage condition. The effectiveness of pasireotide, the only approved pharmaceutical for treatment, varies among patients. Research has found that USP8 gene mutations may be linked to pasireotide response, and overexpressing USP8 mutants may regulate SSTR5 gene expression through stimulating AP-1 transcriptional activity.
ENDOCRINE-RELATED CANCER
(2022)
Article
Chemistry, Multidisciplinary
Hirofumi Ochiai, Taiji Shimoda, Kazuhiro Fukae, Masatoshi Maeda, Kazuyuki Ishii, Kenta Yoshida, Katsunari Tezuka, Keisuke Tazuru, Hayato Saijo, Hiroaki Asai, Akio Kanatani, Yuji Nishiuchi
Summary: Somatostatin, a growth hormone inhibitory factor, can affect physiological functions through its action on five distinct receptor subtypes. By attaching human complex-type oligosaccharides, we have developed glycosylated somatostatin analogues that have improved metabolic stability and high affinity to all receptor subtypes. These analogues have the potential to be novel therapeutic drugs for somatostatin-related diseases and can provide insights into new indications.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Endocrinology & Metabolism
Richard A. Feelders, Maria Fleseriu, Pinar Kadioglu, Marie Bex, Deyanira Gonzalez-Devia, Cesar Luiz Boguszewski, Dilek Gogas Yavuz, Heather Patino, Alberto M. Pedroncelli, Ricardo Maamari, Arghya Chattopadhyay, Beverly M. K. Biller, Rosario Pivonello
Summary: The study evaluated the efficacy and safety of pasireotide alone or combined with cabergoline in patients with Cushing's disease. The addition of cabergoline in patients with persistently elevated cortisol levels on maximum tolerated doses of pasireotide was shown to be effective and well-tolerated in enhancing control of hypercortisolism in some CD patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Kevin C. J. Yuen, Susan L. Samson
Summary: Oral octreotide capsules (OOCs) are an effective treatment option for acromegaly, providing suppression of growth hormone and insulin-like growth factor 1 levels, maintaining disease control, and reducing symptoms. The safety profile of OOC therapy is comparable to injectable somatostatin receptor ligands (SRLs), and patients express a preference for oral administration.
ENDOCRINE PRACTICE
(2022)
Review
Endocrinology & Metabolism
Monica R. Gadelha, Ana Carolina Gadelha, Leandro Kasuki
Summary: The treatment of acromegaly has advanced significantly in recent decades, but there are still patients who do not respond to current treatments, highlighting the need for improved treatment burden. Fortunately, there are new treatments in development that may enhance treatment efficacy and convenience.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Neurosciences
Samuel J. Dienel, Andrew J. Ciesielski, Holly H. Bazmi, Elizabeth A. Profozich, Kenneth N. Fish, David A. Lewis
Summary: The functional output of a cortical region is influenced by its complement of GABA neuron subtypes. Differences in expression patterns of GABA-related transcripts were found between the primate DLPFC and V1, reflecting the diversity in GABA neuron subtypes and gene expression levels per neuron. These findings suggest that specialization of inhibitory neurotransmission across cortical circuits is influenced by variations in the complement of GABA neuron subtypes and gene expression levels per neuron.
Article
Ophthalmology
Bastian Grundel, Marc-Antoine Bernardeau, Holger Langner, Christoph Schmidt, Daniel Boehringer, Marc Ritter, Paul Rosenthal, Andrea Grandjean, Stefan Schulz, Philipp Daumke, Andreas Stahl
Summary: This study utilized text mining to extract information from clinical texts and found that the extraction performance was good for certain data such as visual acuity, intraocular pressure, and accompanying diagnoses, showing potential for future applications. However, manual adjustments are still necessary to improve accuracy.
Article
Health Care Sciences & Services
Stefanie Jauk, Diether Kramer, Alexander Avian, Andrea Berghold, Werner Leodolter, Stefan Schulz
Summary: This study evaluated the user acceptance of a machine learning-based application supporting delirium management in hospitals. Results showed that healthcare professionals found the application useful, easy to understand, and appreciated the additional information provided. However, actual system use was still low during the pilot study.
JOURNAL OF MEDICAL SYSTEMS
(2021)
Correction
Health Care Sciences & Services
Stefanie Jauk, Diether Kramer, Alexander Avian, Andrea Berghold, Werner Leodolter, Stefan Schulz
JOURNAL OF MEDICAL SYSTEMS
(2021)
Article
Medical Informatics
Pilar Lopez-Ubeda, Alexandra Pomares-Quimbaya, Manuel Carlos Diaz-Galiano, Stefan Schulz
Summary: This paper proposes a method to automatically extract and classify Spanish medical terms weighted per sub-domain from MEDLINE titles and abstracts, aiming to reduce the ambiguity and improve NLP tasks in specific clinical specialties. The results demonstrate that the specialized term set SCOVACLIS helps to enhance text classification problems and achieves improvements in F-measure by 6 percentage points compared to a baseline. This study supports the hypothesis that specific term sets can reduce ambiguity compared to a general vocabulary, and highlights the importance of domain-specific resources in biomedical NLP tasks.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2021)
Article
Biochemistry & Molecular Biology
Rainer K. Reinscheid, Fabrizio Mafessoni, Annika Luettjohann, Kay Juengling, Hans-Christian Pape, Stefan Schulz
Summary: The study of the NPS peptide system reveals functional attenuation mutations in human genes, potentially for adaptation to environmental conditions. Ancestral alleles of NPSR1 are found in Neandertal and Denisovan genomes, while derived alleles are present in ancient anatomically modern human genomes, suggesting they arose in modern Homo sapiens. World genotype frequencies for NPSR1 SNPs show regional homogeneity but also support an out-of-Africa scenario, with potential weak or balancing selection indicated by high-frequency polymorphisms. The presence of a hypomorphic mutation in NPS precursor in Eurasian Neandertal genomes suggests introgression into the human gene pool through interbreeding, particularly in Southern Europe.
Article
Biochemistry & Molecular Biology
Belen Juanes Cortes, Jose Antonio Vera-Ramos, Ruth C. Lovering, Pascale Gaudet, Astrid Laegreid, Colin Logie, Stefan Schulz, Maria del Mar Roldan-Garcia, Martin Kuiper, Jesualdo Tomas Fernandez-Breis
Summary: Gene regulation computational research involves handling heterogeneous data by generating knowledge models from gene regulation cartoons using ontologies and semantic tools. These models support data annotation by extracting entities, reusing content from existing ontologies, and implementing the knowledge models. The method was applied to two gene regulation scenarios to illustrate its use in supporting data annotation from research articles.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2021)
Article
Biochemistry & Molecular Biology
Martin Kuiper, Joseph Bonello, Jesualdo T. Fernandez-Breis, Philipp Bucher, Matthias E. Futschik, Pascale Gaudet, Ivan V. Kulakovskiy, Luana Licata, Colin Logie, Ruth C. Lovering, Vsevolod J. Makeev, Sandra Orchard, Simona Panni, Livia Perfetto, David Sant, Stefan Schulz, Steven Vercruysse, Daniel R. Zerbino, Astrid Laegreid
Summary: Following nine workshops organized by GREEKC, experts from around the world worked to improve the Gene Regulation Knowledge Commons (GRKC) by standardizing and updating workflows, as well as involving end-users in the design process, leading to significant achievements in enhancing the GRKC.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Article
Biochemistry & Molecular Biology
David W. Sant, Michael Sinclair, Christopher J. Mungall, Stefan Schulz, Daniel Zerbino, Ruth C. Lovering, Colin Logie, Karen Eilbeck
Summary: The Sequence Ontology (SO) is a structured, controlled vocabulary for genomic annotation. The GREEKC initiative aims to curate information on how gene expression is regulated at the molecular level. Recent updates to the SO include more accurate, human-readable terms, new definitions, and relationships related to gene expression.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2021)
Article
Biochemistry & Molecular Biology
Amelie Lupp, Blanca Ehms, Ralf Stumm, Johannes Goeckeritz, Christian Mawrin, Stefan Schulz
Summary: The researchers investigated the localization of SST4 in normal and neoplastic human tissues using a knockin mouse model expressing SST4-eGFP fusion protein and a novel rabbit monoclonal anti-human SST4 antibody. They demonstrated that SST4 is prominently expressed in certain cells in the cortex and trigeminal ganglion, and the specificity of the antibody was confirmed through immunoblot and preadsorption experiments. The antibody was also found to be valuable for identifying SST4-expressing tumors in adrenal cortex, exocrine pancreas, and other tissues during routine histopathological examinations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Pooja Dasgupta, Thomas Gunther, Stefan Schulz
Summary: Veldoreotide is a full agonist of SSTR2, SSTR4, and SSTR5, showing high potency and efficacy in HEK293 and BON-1 cells.
Article
Biochemistry & Molecular Biology
Maria Bubb, Anna-Sophia Lieselott Beyer, Pooja Dasgupta, Daniel Kaemmerer, Joerg Saenger, Katja Evert, Ralph M. Wirtz, Stefan Schulz, Amelie Lupp
Summary: GPER is widely expressed in human non-neoplastic and neoplastic tissues and a novel antibody has been developed to detect GPER-expressing tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Benjamin Wende, Anna-Sophia Liselott Beyer, Niklas Ruhnke, Daniel Kaemmerer, Joerg Saenger, Stefan Schulz, Amelie Lupp
Summary: A rabbit monoclonal antibody, 8H9L8, was developed for studying the protein expression of CALCRL. The antibody was confirmed to be specific and used for immunohistochemical analyses of normal and neoplastic tissues. CALCRL was found to be expressed in various tissues and showed strong expression in certain tumors, potentially serving as a useful target for future therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Markus Kreuzthaler, Mathias Brochhausen, Cilia Zayas, Bernd Blobel, Stefan Schulz
Summary: This paper provides an overview of the linguistic and ontological challenges in transforming health ecosystems for precision medicine. It discusses the need for standardization and interoperability in clinical and research data representation, as well as smart support for content comprehension by humans and machines. The paper explores the current use of natural language processing in extracting information from healthcare texts and highlights the importance of biomedical ontologies in integrating heterogeneous data sources. It also addresses misconceptions and shortcomings in the field and suggests future steps for data interoperability.
FRONTIERS IN MEDICINE
(2023)
Article
Biology
Sebastian Fritzwanker, Falko Nagel, Andrea Kliewer, Viviane Stammer, Stefan Schulz
Summary: Phosphorylation of receptors is unstable during routine immunohistochemical procedures, requiring the use of phosphatase inhibitors for specific GPCR antibodies. We showed that phosphorylation of receptors is highly unstable during routine immunohistochemical procedures, and the use of phosphatase inhibitors is necessary for specific GPCR antibodies. Our findings were confirmed using phosphorylation state-specific MOP and CB1 antibodies.
COMMUNICATIONS BIOLOGY
(2023)
Meeting Abstract
Behavioral Sciences
Masao Miyazaki, Jana Caspers, Tamako Miyazaki, Reiko Uenoyama, Shota Ichizawa, Stefan Schulz