Hsp90 Inhibitor SNX-2112 Enhances TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via the ROS-Mediated JNK-p53-Autophagy-DR5 Pathway

Ginkgolic acid induces interplay between apoptosis and autophagy regulated by ROS generation in colon cancer

(2018) Yuxia Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy

(2018) Lynne Postovit et al.   Oxidative Medicine and Cellular Longevity

Oxygen availability and metabolic reprogramming in cancer

(2017) Hong Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells

(2017) Kyoung-jin Min et al.   MOLECULES

Hsp90 inhibitor induces KG-1a cell differentiation and apoptosis via Akt/NF-κB signaling

(2017) Jin-Hong Qin et al.   ONCOLOGY REPORTS

Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells in vitro and in vivo

(2017) Jian Zhu et al.   Cell Death & Disease

A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells

(2017) Lin Zhao et al.   Cell Death & Disease

HSP90 inhibitor 17-DMAG exerts anticancer effects against gastric cancer cells principally by altering oxidant-antioxidant balance

(2017) Jeong Goo Kim et al.   Oncotarget

Anhuienoside C Ameliorates Collagen-Induced Arthritis through Inhibition of MAPK and NF-κB Signaling Pathways

(2017) Qing Liu et al.   Frontiers in Pharmacology

Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation

(2016) Lei Chen et al.   APOPTOSIS

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Effect of SNX-2112 on proliferation of esophageal cancer cells via regulation of excision repair cross-complementing 1, epidermal growth factor receptor, and p53 expression

(2016) C.Y. Li et al.   GENETICS AND MOLECULAR RESEARCH

Involvement of DR4/JNK pathway-mediated autophagy in acquired TRAIL resistance in HepG2 cells

(2016) Sung-Chul Lim et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells

(2016) Dongzhu Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Etoposide induces pancreatic β-cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway

(2016) Kuan-I Lee et al.   TOXICOLOGY IN VITRO

Goniothalamin induces mitochondria-mediated apoptosis associated with endoplasmic reticulum stress-induced activation of JNK in HeLa cells

(2016) Thanet Sophonnithiprasert et al.   Oncology Letters

Cantharidin Induced Oral Squamous Cell Carcinoma Cell Apoptosis via the JNK-Regulated Mitochondria and Endoplasmic Reticulum Stress-Related Signaling Pathways

(2016) Chin-Chuan Su et al.   PLoS One

Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner

(2016) Minghui Chen et al.   Scientific Reports

Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy

(2015) Minghua Yang et al.   Autophagy

Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines

(2015) Chia-Che Chang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy

(2015) Fang-Yuan Shao et al.   Oncotarget

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5

(2015) Xu Di et al.   Oncotarget

Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma

(2015) Ming-Huang Chen et al.   Oncotarget

Autophagy and apoptosis: where do they meet?

(2014) Subhadip Mukhopadhyay et al.   APOPTOSIS

The Hsp90 inhibitor SNX-2112 induces apoptosis of human hepatocellular carcinoma cells: The role of ER stress

(2014) Xiao Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the Death Receptor pathway

(2014) Zhiyu Chen et al.   CANCER LETTERS

Getting TRAIL back on track for cancer therapy

(2014) J Lemke et al.   CELL DEATH AND DIFFERENTIATION

Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK–CHOP signaling pathways

(2014) Minh Truong Do et al.   FOOD AND CHEMICAL TOXICOLOGY

HSP90 Inhibitor SNX5422/ 2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma

(2014) Jay A. Friedman et al.   Translational Oncology

Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

(2014) R Trivedi et al.   Cell Death & Disease

Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines

(2013) Ming-Ju Hsieh et al.   ARCHIVES OF TOXICOLOGY

TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages

(2013) Bao-Zhu Yuan et al.   BMC CANCER

Inhibition of the mitochondrial Hsp90 chaperone network: A novel, efficient treatment strategy for cancer?

(2013) Markus D. Siegelin   CANCER LETTERS

Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells

(2013) Chao Zhang et al.   CANCER LETTERS

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

(2013) K Azijli et al.   CELL DEATH AND DIFFERENTIATION

The Hsp90 inhibitor SNX-2112, induces apoptosis in multidrug resistant K562/ADR cells through suppression of Akt/NF-κB and disruption of mitochondria-dependent pathways

(2013) Rui Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp.

(2013) Skylar Carlson et al.   Marine Drugs

Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells

(2012) Qilin Wang et al.   Cancer Cell International

Cell Death via DR5, but not DR4, Is Regulated by p53 in Myeloma Cells

(2012) S. Surget et al.   CANCER RESEARCH

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Bortezomib and TRAIL: A perfect match for apoptotic elimination of tumour cells?

(2012) L.H.A.M. de Wilt et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

The Therapeutic Target Hsp90 and Cancer Hallmarks

(2012) Yoshihiko Miyata et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Targets of TRAIL-Sensitizing Agents in Colorectal Cancer

(2012) Carmine Stolfi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Isoobtusilactone A Sensitizes Human Hepatoma Hep G2 Cells to TRAIL-Induced Apoptosis via ROS and CHOP-Mediated Up-regulation of DR5

(2012) Chung-Yi Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Triptolide sensitizes TRAIL-induced apoptosis in prostate cancer cells via p53-mediated DR5 up-regulation

(2012) Hu Xiaowen et al.   MOLECULAR BIOLOGY REPORTS

On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

(2012) L Y Dimberg et al.   ONCOGENE

The heat shock protein 90 inhibitor SNX-2112 inhibits B16 melanoma cell growth in vitro and in vivo

(2012) Yi-Fei Wang   ONCOLOGY REPORTS

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

(2011) Komal Jhaveri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SNX-2112, a Novel Hsp90 Inhibitor, Induces G2/M Cell Cycle Arrest and Apoptosis in MCF-7 Cells

(2011) Shao-Xiang WANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

A phase II study of 17-allylamino-17-demethoxygeldanamycin in metastatic or locally advanced, unresectable breast cancer

(2011) Elaina M. Gartner et al.   BREAST CANCER RESEARCH AND TREATMENT

SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells

(2011) Kai-Sheng Liu et al.   CANCER LETTERS

HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab

(2011) S. Modi et al.   CLINICAL CANCER RESEARCH

HSP90 inhibition: two-pronged exploitation of cancer dependencies

(2011) Jon Travers et al.   DRUG DISCOVERY TODAY

Glucocorticoid receptor antagonist sensitizes TRAIL-induced apoptosis in renal carcinoma cells through up-regulation of DR5 and down-regulation of c-FLIP(L) and Bcl-2

(2011) Kyoung-jin Min et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The role of reactive oxygen species and autophagy in safingol-induced cell death

(2011) L-U Ling et al.   Cell Death & Disease

HSP90 modulates actin dynamics: Inhibition of HSP90 leads to decreased cell motility and impairs invasion

(2010) Aftab Taiyab et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies

(2010) James E. H. Day et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma

(2010) Simon Pacey et al.   INVESTIGATIONAL NEW DRUGS

Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma

(2009) Aftab Taiyab et al.   BIOCHEMICAL PHARMACOLOGY

Notch1 Signaling Sensitizes Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Human Hepatocellular Carcinoma Cells by Inhibiting Akt/Hdm2-mediated p53 Degradation and Up-regulating p53-dependent DR5 Expression

(2009) Chunmei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorothioate-Modified TLR9 Ligands Protect Cancer Cells against TRAIL-Induced Apoptosis

(2009) D. Chiron et al.   JOURNAL OF IMMUNOLOGY

SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

(2008) Y. Okawa et al.   BLOOD

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

(2008) B. Z. Carter et al.   BLOOD

TRAIL receptor signalling and modulation: Are we on the right TRAIL?

(2008) Devalingam Mahalingam et al.   CANCER TREATMENT REVIEWS

17-AAG sensitized malignant glioma cells to death-receptor mediated apoptosis

(2008) Markus David Siegelin et al.   NEUROBIOLOGY OF DISEASE