Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

Proapoptotic Activation of Death Receptor 5 on Tumor Endothelial Cells Disrupts the Vasculature and Reduces Tumor Growth

(2012) Nicholas S. Wilson et al.   CANCER CELL

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

(2012) S Jouan-Lanhouet et al.   CELL DEATH AND DIFFERENTIATION

Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells

(2012) K. Azijli et al.   JOURNAL OF CELL SCIENCE

Phase I Trial and Pharmacokinetic Study of Lexatumumab in Pediatric Patients With Solid Tumors

(2012) Melinda S. Merchant et al.   JOURNAL OF CLINICAL ONCOLOGY

TRAIL Signaling and Synergy Mechanisms Used in TRAIL-Based Combination Therapies

(2012) C. T. Hellwig et al.   MOLECULAR CANCER THERAPEUTICS

Many stimuli pull the necrotic trigger, an overview

(2011) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation

(2011) Joo-Young Kim et al.   FEBS LETTERS

TRAIL-Induced Keratinocyte Differentiation Requires Caspase Activation and p63 Expression

(2011) Nan-Lin Wu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

(2011) Domagoj Vucic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells

(2011) C Jennewein et al.   ONCOGENE

TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT

(2011) Najoua Lalaoui et al.   PLoS One

TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1

(2010) J K Son et al.   CELL DEATH AND DIFFERENTIATION

Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation

(2010) M Ehrenschwender et al.   CELL DEATH AND DIFFERENTIATION

TRAIL Promotes VSMC Proliferation and Neointima Formation in a FGF-2–, Sp1 Phosphorylation–, and NFκB-Dependent Manner

(2010) Jeffrey Chan et al.   CIRCULATION RESEARCH

The role of TRADD in TRAIL-induced apoptosis and signaling

(2010) Xiumei Cao et al.   FASEB JOURNAL

Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells

(2010) Frederik J.H. Hoogwater et al.   GASTROENTEROLOGY

Phase 1b Study of Dulanermin (recombinant human Apo2L/TRAIL) in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Patients With Advanced Non-Squamous Non–Small-Cell Lung Cancer

(2010) Jean-Charles Soria et al.   JOURNAL OF CLINICAL ONCOLOGY

TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5

(2010) Johannes Lemke et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

New insights into apoptosis signaling by Apo2L/TRAIL

(2010) F Gonzalvez et al.   ONCOGENE

TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-κB Dependent Induction of cFLIPL

(2010) Josep Maria Lluis et al.   PLoS One

Activation of the Akt Survival Pathway Contributes to TRAIL Resistance in Cancer Cells

(2010) Jing Xu et al.   PLoS One

Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death

(2009) Kyung-Jin Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines

(2009) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

(2009) Xiang H.-F. Zhang et al.   CANCER CELL

c-Cbl acts as a mediator of Src-induced activation of the PI3K-Akt signal transduction pathway during TRAIL treatment

(2009) Jae J. Song et al.   CELLULAR SIGNALLING

TRAIL receptor targeting therapies for non-small cell lung cancer: Current status and perspectives

(2009) J.H. Stegehuis et al.   DRUG RESISTANCE UPDATES

DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas

(2009) Anita C. Bellail et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Death receptor signal transducers: nodes of coordination in immune signaling networks

(2009) Nicholas S Wilson et al.   NATURE IMMUNOLOGY

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP

(2009) S Morioka et al.   ONCOGENE

Yes and PI3K Bind CD95 to Signal Invasion of Glioblastoma

(2008) Susanne Kleber et al.   CANCER CELL

Src and ADAM-17-Mediated Shedding of Transforming Growth Factor-  Is a Mechanism of Acute Resistance to TRAIL

(2008) S. Van Schaeybroeck et al.   CANCER RESEARCH

Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5

(2008) C Adams et al.   CELL DEATH AND DIFFERENTIATION

TRAIL induces proliferation of human glioma cells by c-FLIPL-mediated activation of ERK1/2

(2008) U. Vilimanovich et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily

(2008) Jae J. Song et al.   CELLULAR SIGNALLING

A Phase 1 Study of Mapatumumab (Fully Human Monoclonal Antibody to TRAIL-R1) in Patients with Advanced Solid Malignancies

(2008) S. J. Hotte et al.   CLINICAL CANCER RESEARCH

JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand

(2008) S R Mucha et al.   GUT

TRAIL Stimulates Proliferation of Vascular Smooth Muscle Cells via Activation of NF-κB and Induction of Insulin-like Growth Factor-1 Receptor

(2008) Mary M. Kavurma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development

(2008) Anne Grosse-Wilde et al.   JOURNAL OF CLINICAL INVESTIGATION

TRAIL-induced survival and proliferation of SCLC cells is mediated by ERK and dependent on TRAIL-R2/DR5 expression in the absence of caspase-8

(2008) Larisa L. Belyanskaya et al.   LUNG CANCER

TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation from monocyte/macrophage lineage precursor cells

(2008) Men-Luh Yen et al.   MOLECULAR IMMUNOLOGY

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

(2008) Avi Ashkenazi   NATURE REVIEWS DRUG DISCOVERY

Protein kinase Cɛ confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53

(2008) E Shankar et al.   ONCOGENE