FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX

FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway

(2017) Wen Li et al.   ENDOCRINOLOGY

Effect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome

(2017) Dae Hyun Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Overexpression of FOXO1 ameliorates the podocyte epithelial–mesenchymal transition induced by high glucose in vitro and in vivo

(2016) Mengmeng Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity

(2016) Munehiro Kitada et al.   DIABETOLOGIA

Thioredoxin-interacting protein regulates lipid metabolism via Akt/mTOR pathway in diabetic kidney disease

(2016) Chunyang Du et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

CD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway

(2016) Xiao-Hui Guan et al.   Oxidative Medicine and Cellular Longevity

Lentiviral Vector-Mediated FoxO1 Overexpression Inhibits Extracellular Matrix Protein Secretion Under High Glucose Conditions in Mesangial Cells

(2015) Feng Guo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy

(2015) A. Shah et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activation of FoxO1/ PGC-1α prevents mitochondrial dysfunction and ameliorates mesangial cell injury in diabetic rats

(2015) Lina Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

FOXO/TXNIP pathway is involved in the suppression of hepatocellular carcinoma growth by glutamate antagonist MK-801

(2013) Fuminori Yamaguchi et al.   BMC CANCER

Knockdown of thioredoxin-interacting protein ameliorates high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells

(2013) Jinying Wei et al.   CELLULAR SIGNALLING

Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay

(2013) Loredana Fiorentino et al.   EMBO Molecular Medicine

FOXO1 Competes with Carbohydrate Response Element-binding Protein (ChREBP) and Inhibits Thioredoxin-interacting Protein (TXNIP) Transcription in Pancreatic Beta Cells

(2013) Carly Kibbe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of FOXO1 in β-cell failure and type 2 diabetes mellitus

(2013) Tadahiro Kitamura   Nature Reviews Endocrinology

Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress

(2012) Bhaskar Ponugoti et al.   Experimental Diabetes Research

Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis

(2012) Caroline S Fox et al.   LANCET

Glucose-Mediated Repression of Menin Promotes Pancreatic β-Cell Proliferation

(2011) Hongli Zhang et al.   ENDOCRINOLOGY

Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA

(2011) Zsolt Radak et al.   MOLECULAR ASPECTS OF MEDICINE

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

(2010) Xinguo Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid-Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin

(2009) X.-N. Li et al.   DIABETES

Urocortin ameliorates diabetic nephropathy in obesedb/dbmice

(2008) X Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Combination of Genomic Approaches Reveals the Role of FOXO1a in Regulating an Oxidative Stress Response Pathway

(2008) Paola de Candia et al.   PLoS One