Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia

Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

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Bicarbonate Alters Bacterial Susceptibility to Antibiotics by Targeting the Proton Motive Force

(2017) Maya A. Farha et al.   ACS Infectious Diseases

Role of CFTR in epithelial physiology

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Acidic pH increases airway surface liquid viscosity in cystic fibrosis

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Pre-transmetalation intermediates in the Suzuki-Miyaura reaction revealed: The missing link

(2016) A. A. Thomas et al.   SCIENCE

Airway acidification initiates host defense abnormalities in cystic fibrosis mice

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Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion

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C3-OH of Amphotericin B Plays an Important Role in Ion Conductance

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Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel

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Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR

(2015) Claire E. Wainwright et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cystic fibrosis

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Amphotericin forms an extramembranous and fungicidal sterol sponge

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Synthetic transporters for sulfate: a new method for the direct detection of lipid bilayer sulfate transport

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Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor

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Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

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Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

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NIH Image to ImageJ: 25 years of image analysis

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A Synthetic Chloride Channel Restores Chloride Conductance in Human Cystic Fibrosis Epithelial Cells

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Amphotericin primarily kills yeast by simply binding ergosterol

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Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching

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A CFTR Potentiator in Patients with Cystic Fibrosis and theG551DMutation

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Acid and base secretion in freshly excised nasal tissue from cystic fibrosis patients with ΔF508 mutation

(2011) Do-Yeon Cho et al.   International Forum of Allergy & Rhinology

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(2010) Do-Yeon Cho et al.   American Journal of Rhinology & Allergy

Tripodal transmembrane transporters for bicarbonate

(2010) Nathalie Busschaert et al.   CHEMICAL COMMUNICATIONS

Design, Validation, and Implementation of a Rapid-Injection NMR System

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Structurally simple lipid bilayer transport agents for chloride and bicarbonate

(2010) Natalie J. Andrews et al.   Chemical Science

AMPK Agonists Ameliorate Sodium and Fluid Transport and Inflammation in Cystic Fibrosis Airway Epithelial Cells

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Nebulized Liposomal Amphotericin B Prophylaxis for Aspergillus Infection in Lung Transplantation: Pharmacokinetics and Safety

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Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes

(2009) Jeffery T. Davis et al.   Nature Chemistry

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

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