Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion

Airway acidification initiates host defense abnormalities in cystic fibrosis mice

(2016) V. S. Shah et al.   SCIENCE

Coculture of Staphylococcus aureus with Pseudomonas aeruginosa Drives S. aureus towards Fermentative Metabolism and Reduced Viability in a Cystic Fibrosis Model

(2015) Laura M. Filkins et al.   JOURNAL OF BACTERIOLOGY

Hemichannel-mediated release of lactate

(2015) Anastassios Karagiannis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure

(2014) Ashley G. Henderson et al.   JOURNAL OF CLINICAL INVESTIGATION

The Warburg effect: a balance of flux analysis

(2014) B. Vaitheesvaran et al.   Metabolomics

The Monocarboxylate Transporter Inhibitor α-Cyano-4-Hydroxycinnamic Acid Disrupts Rat Lung Branching

(2013) Sara Granja et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Early assessment of glucose abnormalities during continuous glucose monitoring associated with lung function impairment in cystic fibrosis patients

(2013) A. Leclercq et al.   Journal of Cystic Fibrosis

A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells

(2013) Alejandro San Martín et al.   PLoS One

Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth

(2013) James P. Garnett et al.   PLoS One

Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

(2013) A. L. Garland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin reduces airway glucose permeability and hyperglycaemia-inducedStaphylococcus aureusload independently of effects on blood glucose

(2013) James P Garnett et al.   THORAX

Proinflammatory Mediators Disrupt Glucose Homeostasis in Airway Surface Liquid

(2012) J. P. Garnett et al.   JOURNAL OF IMMUNOLOGY

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

(2012) Alejandro A. Pezzulo et al.   NATURE

Incidence and Risk Factors for Pulmonary Exacerbation Treatment Failures in Patients With Cystic Fibrosis Chronically Infected With Pseudomonas aeruginosa

(2011) Michael D. Parkins et al.   CHEST

Novel Role for Pendrin in Orchestrating Bicarbonate Secretion in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-expressing Airway Serous Cells

(2011) James P. Garnett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary bronchial epithelial cell culture from explanted cystic fibrosis lungs

(2010) Malcolm Brodlie et al.   EXPERIMENTAL LUNG RESEARCH

Lactate in cystic fibrosis sputum

(2010) Tobias Bensel et al.   Journal of Cystic Fibrosis

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10

(2009) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

Myocardial glucose and lactate metabolism during rest and atrial pacing in humans

(2009) Bryan C. Bergman et al.   JOURNAL OF PHYSIOLOGY-LONDON