9-Methylfascaplysin Is a More Potent Aβ Aggregation Inhibitor than the Marine-Derived Alkaloid, Fascaplysin, and Produces Nanomolar Neuroprotective Effects in SH-SY5Y Cells

Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β

(2018) Jialing Wang et al.   ACS Chemical Neuroscience

Marine natural product peptides with therapeutic potential: Chemistry, biosynthesis, and pharmacology

(2018) Vedanjali Gogineni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Prion Protein as a Toxic Acceptor of Amyloid-β Oligomers

(2018) Silvia A. Purro et al.   BIOLOGICAL PSYCHIATRY

Marine natural products for multi-targeted cancer treatment: A future insight

(2018) Maushmi S. Kumar et al.   BIOMEDICINE & PHARMACOTHERAPY

Design, synthesis and evaluation of novel bivalent β -carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease

(2018) Yifan Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Alzheimer's disease in the omics era

(2018) Giulia M. Sancesario et al.   CLINICAL BIOCHEMISTRY

Curcumin-based electrochemical sensor of amyloid-β oligomer for the early detection of Alzheimer’s disease

(2018) Jieling Qin et al.   SENSORS AND ACTUATORS B-CHEMICAL

Alzheimer Disease

(2018) Maileen Gloriane Ulep et al.   JNP-Journal for Nurse Practitioners

Cooperative fibril model: Native, amyloid-like fibril and unfolded states of proteins

(2018) J.S. Espinoza Ortiz et al.   PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS

Neuroprotective effects of bergenin in Alzheimer’s disease: Investigation through molecular docking, in vitro and in vivo studies

(2018) Priyal Barai et al.   BEHAVIOURAL BRAIN RESEARCH

Aerobic Oxidation of Methyl‐substituted β ‐Carbolines Catalyzed by N‐Hydroxyphthalimide and Metal Catalyst

(2018) Hongda Qiu et al.   ChemistrySelect

Antifungal potential of marine natural products

(2017) Ebaa M. El-Hossary et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fascaplysin inhibit ovarian cancer cell proliferation and metastasis through inhibiting CDK4

(2017) Shuo Chen et al.   GENE

Fucoxanthin Inhibits β-Amyloid Assembly and Attenuates β-Amyloid Oligomer-Induced Cognitive Impairments

(2017) Siying Xiang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

5-Hydroxycyclopenicillone Inhibits β-Amyloid Oligomerization and Produces Anti-β-Amyloid Neuroprotective Effects In Vitro

(2017) Jiaying Zhao et al.   MOLECULES

APP/Aβ structural diversity and Alzheimer's disease pathogenesis

(2017) Alex E. Roher et al.   NEUROCHEMISTRY INTERNATIONAL

Brazilin inhibits fibrillogenesis of human islet amyloid polypeptide, disassembles mature fibrils, and alleviates cytotoxicity

(2017) Jingjing Guo et al.   RSC Advances

Structural differences between amyloid beta oligomers

(2016) Leonid Breydo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure–activity relationship

(2016) Sudhakar Manda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hematoxylin Inhibits Amyloid β-Protein Fibrillation and Alleviates Amyloid-Induced Cytotoxicity

(2016) Yilong Tu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Aβ-42 lowering agents from the marine-derived fungus Dichotomomyces cejpii

(2015) Henrik Harms et al.   STEROIDS

Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity

(2015) Wen-Jie Du et al.   Scientific Reports

g_mmpbsa—A GROMACS Tool for High-Throughput MM-PBSA Calculations

(2014) Rashmi Kumari et al.   Journal of Chemical Information and Modeling

Testing and validation of the Automated Topology Builder (ATB) version 2.0: prediction of hydration free enthalpies

(2014) Katarzyna B. Koziara et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

9-Methyl-β-carboline has restorative effects in an animal model of Parkinson’s disease

(2014) Catrin Wernicke et al.   Pharmacological Reports

A Cascade Coupling Strategy for One-Pot Total Synthesis of β-Carboline and Isoquinoline-Containing Natural Products and Derivatives

(2013) Yan-Ping Zhu et al.   CHEMISTRY-A EUROPEAN JOURNAL

A new method for the synthesis of the marine alkaloid fascaplysin based on the microwave-assisted Minisci reaction

(2013) Maxim E. Zhidkov et al.   TETRAHEDRON LETTERS

The case for soluble Aβ oligomers as a drug target in Alzheimer's disease

(2013) Franz Hefti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Design, synthesis and in vitro and in vivo antitumor activities of novel bivalent β-carbolines

(2012) Buxi Shi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploring the inter-molecular interactions in amyloid-β protofibril with molecular dynamics simulations and molecular mechanics Poisson-Boltzmann surface area free energy calculations

(2012) Fu-Feng Liu et al.   JOURNAL OF CHEMICAL PHYSICS

Definition and testing of the GROMOS force-field versions 54A7 and 54B7

(2011) Nathan Schmid et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Molecular Insight into Conformational Transition of Amyloid β-Peptide 42 Inhibited by (−)-Epigallocatechin-3-gallate Probed by Molecular Simulations

(2011) Fu-Feng Liu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

α-Mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation

(2011) Yan Wang et al.   NEUROPHARMACOLOGY

Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide

(2010) Spyridon Mourtas et al.   BIOMATERIALS

Salvianolic acid B inhibits Aβ fibril formation and disaggregates preformed fibrils and protects against Aβ-induced cytotoxicty

(2007) Siva Sundara Kumar Durairajan et al.   NEUROCHEMISTRY INTERNATIONAL