Blood-brain barrier permeability and physical exercise

Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women

(2018) Matheus Uba Chupel et al.   Applied Physiology Nutrition and Metabolism

Improvement of cognitive functions in response to a regular Nordic walking training in elderly women – A change dependent on the training experience

(2018) A. Gmiąt et al.   EXPERIMENTAL GERONTOLOGY

Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model

(2018) Ronggui Lin et al.   Journal of Inflammation-London

Exercise-induced changes in neurotrophic factors and markers of blood-brain barrier permeability are moderated by weight status in multiple sclerosis

(2018) Motahare Mokhtarzade et al.   NEUROPEPTIDES

MRI measurements of Blood-Brain Barrier function in dementia: A review of recent studies

(2018) Rajikha Raja et al.   NEUROPHARMACOLOGY

Triangulated Mal-Signaling in Alzheimer's Disease: Roles of Neurotoxic Ceramides, ER Stress, and Insulin Resistance Reviewed

(2018) Suzanne M. de la Monte   JOURNAL OF ALZHEIMERS DISEASE

Endocrine Crosstalk Between Skeletal Muscle and the Brain

(2018) Julien Delezie et al.   Frontiers in Neurology

Upregulation of the lactate transporter monocarboxylate transporter 1 at the blood-brain barrier in a rat model of attention-deficit/hyperactivity disorder suggests hyperactivity could be a form of self-treatment

(2018) Tirill Medin et al.   BEHAVIOURAL BRAIN RESEARCH

Effect of Exercise Intensity on Neurotrophic Factors and Blood–Brain Barrier Permeability Induced by Oxidative–Nitrosative Stress in Male College Students

(2017) Hee-Tae Roh et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Mohsen Naghavi et al.   LANCET

Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

(2017) Igor Cervenka et al.   SCIENCE

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

(2017) Cecilie Morland et al.   Nature Communications

Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease

(2017) Roger J. Mullins et al.   Frontiers in Aging Neuroscience

Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption after high-intensity exercise

(2017) Hee-Tae Roh et al.   Journal of Sport and Health Science

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

(2017) Xiao-fei He et al.   Frontiers in Molecular Neuroscience

Maintenance of Blood-Brain Barrier Integrity in Hypertension: A Novel Benefit of Exercise Training for Autonomic Control

(2017) Leila Buttler et al.   Frontiers in Physiology

The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials

(2016) C. Groot et al.   AGEING RESEARCH REVIEWS

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans

(2016) Maja Schlittler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Evidence for a specialized role of the locus coeruleus noradrenergic system in cortical circuitries and behavioral operations

(2016) Daniel J. Chandler   BRAIN RESEARCH

Basic science behind the cardiovascular benefits of exercise

(2016) Mathew G Wilson et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Neuroinflammatory mechanisms of hypertension

(2016) Pawel J. Winklewski et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Association of Oxidative Stress with Psychiatric Disorders

(2016) Waseem Hassan et al.   CURRENT PHARMACEUTICAL DESIGN

Trends in Obesity Among Adults in the United States, 2005 to 2014

(2016) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Exercise Prevents Amyloid-β-Induced Hippocampal Network Disruption by Inhibiting GSK3β Activation

(2016) Arturo G. Isla et al.   JOURNAL OF ALZHEIMERS DISEASE

Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: noradrenergic signaling system

(2016) Douglas L. Feinstein et al.   JOURNAL OF NEUROCHEMISTRY

Inflammatory Markers in Obese Adolescents with Type 2 Diabetes and Their Relationship to Hepatokines and Adipokines

(2016) Thomas Reinehr et al.   JOURNAL OF PEDIATRICS

Physical Exercise Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Peripheral Immune Response and Blood-Brain Barrier Disruption

(2016) Priscila S. Souza et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer’s disease

(2015) Amandine Grimm et al.   BIOGERONTOLOGY

Physical training improves non-spatial memory, locomotor skills and the blood brain barrier in diabetic rats

(2015) Priscylla Nunes de Senna et al.   BRAIN RESEARCH

Association between the PPARGC1A Polymorphism and Aerobic Capacity in Japanese Middle-aged Men

(2015) Yuichiro Nishida et al.   INTERNAL MEDICINE

Compromised blood-brain barrier permeability: novel mechanism by which circulating angiotensin II signals to sympathoexcitatory centres during hypertension

(2015) V. C. Biancardi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of Differentiation and Function of Helper T Cells by Lymphocyte-Derived Catecholamines via a1- and �2-Adrenoceptors

(2015) Hui-Wei Huang et al.   NEUROIMMUNOMODULATION

Early changes in extracellular matrix in Alzheimer's disease

(2015) F.-X. Lepelletier et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders

(2015) G.Z. Réus et al.   NEUROSCIENCE

Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes

(2015) Takhar Kasumov et al.   Obesity

The Link Between Physical Activity and Cognitive Dysfunction in Alzheimer Disease

(2015) C. Phillips et al.   PHYSICAL THERAPY

A systematic review and meta-analysis of exercise interventions in schizophrenia patients

(2015) J. Firth et al.   PSYCHOLOGICAL MEDICINE

Exercise Improves Clinical Symptoms, Quality of Life, Global Functioning, and Depression in Schizophrenia: A Systematic Review and Meta-analysis

(2015) Meenakshi Dauwan et al.   SCHIZOPHRENIA BULLETIN

Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease

(2015) Paola Gamba et al.   Frontiers in Aging Neuroscience

Reversing Heart Failure–Associated Pathophysiology with Exercise

(2015) Volker Adams et al.   Heart Failure Clinics

Biochemical Markers of Physical Exercise on Mild Cognitive Impairment and Dementia: Systematic Review and Perspectives

(2015) Camilla Steen Jensen et al.   Frontiers in Neurology

Early Training-Induced Reduction of Angiotensinogen in Autonomic Areas—The Main Effect of Exercise on Brain Renin-Angiotensin System in Hypertensive Rats

(2015) Laiali Jurdi Chaar et al.   PLoS One

Improved Physical Fitness Correlates With Improved Cognition in Multiple Sclerosis

(2014) Meghan Beier et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial

(2014) Lisanne F ten Brinke et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Effect of Physical Exercise on Cognitive Performance in Older Adults with Mild Cognitive Impairment or Dementia: A Systematic Review

(2014) Hanna Öhman et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

(2014) Nathalie Esser et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Effects of exercise training on depression in patients with heart failure: a systematic review and meta-analysis of randomized controlled trials

(2014) Rong-Hui Tu et al.   EUROPEAN JOURNAL OF HEART FAILURE

Lactate Transport and Signaling in the Brain: Potential Therapeutic Targets and Roles in Body—Brain Interaction

(2014) Linda Hildegard Bergersen   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Physical Activity Interventions for People With Mental Illness

(2014) Simon Rosenbaum et al.   JOURNAL OF CLINICAL PSYCHIATRY

Exercise Training Attenuates Hypertension and Cardiac Hypertrophy by Modulating Neurotransmitters and Cytokines in Hypothalamic Paraventricular Nucleus

(2014) Lin-Lin Jia et al.   PLoS One

Time-Dependent Effects of Training on Cardiovascular Control in Spontaneously Hypertensive Rats: Role for Brain Oxidative Stress and Inflammation and Baroreflex Sensitivity

(2014) Gustavo S. Masson et al.   PLoS One

Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention

(2014) Natasa Rajkovic et al.   International Journal of Environmental Research and Public Health

The neuropathology of sport

(2013) Ann C. McKee et al.   ACTA NEUROPATHOLOGICA

Kynurenic acid, by targeting α7 nicotinic acetylcholine receptors, modulates extracellular GABA levels in the rat striatumin vivo

(2013) Sarah Beggiato et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis

(2013) Guo-Xiang Ruan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased blood–brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model

(2013) Shuko Takeda et al.   NEUROBIOLOGY OF AGING

Aerobic exercise increases hippocampal volume and improves memory in multiple sclerosis: Preliminary findings

(2013) V. M. Leavitt et al.   NEUROCASE

Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

(2013) Servio H. Ramirez et al.   PLoS One

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

Clinical Importance of Steps Taken per Day among Persons with Multiple Sclerosis

(2013) Robert W. Motl et al.   PLoS One

S100B as a Marker for Brain Damage and Blood–Brain Barrier Disruption Following Exercise

(2013) Serene X. T. Koh et al.   SPORTS MEDICINE

Bridging animal and human models of exercise-induced brain plasticity

(2013) Michelle W. Voss et al.   TRENDS IN COGNITIVE SCIENCES

Metabolic signaling by lactate in the brain

(2013) L. Felipe Barros   TRENDS IN NEUROSCIENCES

Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective

(2013) Harris A. Eyre et al.   Frontiers in Psychiatry

The blood-brain barrier in health and disease

(2012) Richard Daneman   ANNALS OF NEUROLOGY

The blood-brain barrier hypothesis in drug resistant epilepsy

(2012) N. Marchi et al.   BRAIN

Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions

(2012) Anna Raabe et al.   EPILEPSIA

Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis

(2012) Soo Young Kim et al.   EPILEPSIA

Quinolinic acid, the inescapable neurotoxin

(2012) Gilles J. Guillemin   FEBS Journal

Sympathoinhibition caused by orally administered telmisartan through inhibition of the AT1 receptor in the rostral ventrolateral medulla of hypertensive rats

(2012) Takuya Kishi et al.   HYPERTENSION RESEARCH

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

(2012) Karlie A. Intlekofer et al.   NEUROBIOLOGY OF DISEASE

Norepinephrine: A Neuromodulator That Boosts the Function of Multiple Cell Types to Optimize CNS Performance

(2012) John O’Donnell et al.   NEUROCHEMICAL RESEARCH

S100B Engages RAGE or bFGF/FGFR1 in Myoblasts Depending on Its Own Concentration and Myoblast Density. Implications for Muscle Regeneration

(2012) Francesca Riuzzi et al.   PLoS One

Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR

(2011) Deepmala Agarwal et al.   BASIC RESEARCH IN CARDIOLOGY

The beta2-adrenergic receptor on T and B lymphocytes: Do we understand it yet?

(2011) Virginia M. Sanders   BRAIN BEHAVIOR AND IMMUNITY

Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties

(2011) Edite Teixeira-Lemos et al.   Cardiovascular Diabetology

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke

(2011) Kim M. Baeten et al.   Developmental Neurobiology

Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide

(2011) J. J. Dubé et al.   DIABETOLOGIA

Exercise-induced oxidative-nitrosative stress is associated with impaired dynamic cerebral autoregulation and blood-brain barrier leakage

(2011) Damian M. Bailey et al.   EXPERIMENTAL PHYSIOLOGY

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

Autonomic-Immune-Vascular Interaction

(2011) Jasenka Zubcevic et al.   HYPERTENSION

Exercise Training Increases Interleukin-10 after an Acute Myocardial Infarction: A Randomised Clinical Trial

(2011) F. Ribeiro et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function

(2011) David R. Raleigh et al.   JOURNAL OF CELL BIOLOGY

Oxidative stress in the rostral ventrolateral medulla modulates excitatory and inhibitory inputs in spontaneously hypertensive rats

(2011) Masaaki Nishihara et al.   JOURNAL OF HYPERTENSION

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contributions of vascular inflammation in the brainstem for neurogenic hypertension

(2011) Hidefumi Waki et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis?

(2011) Ulrik Dalgas et al.   Therapeutic Advances in Neurological Disorders

The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia

(2010) Costantino Iadecola   ACTA NEUROPATHOLOGICA

Inhibition of Glycogen Synthase Kinase 3β (GSK3β) Decreases Inflammatory Responses in Brain Endothelial Cells

(2010) Servio H. Ramirez et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of Aerobic Exercise on Mild Cognitive Impairment

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Disruption of central nervous system barriers in multiple sclerosis

(2010) Jorge Ivan Alvarez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Importance of angiotensinergic mechanisms for the pressor response to l-glutamate into the rostral ventrolateral medulla

(2010) Alexandre Antonio Vieira et al.   BRAIN RESEARCH

Exercise training attenuates oxidative stress and decreases p53 protein content in skeletal muscle of type 2 diabetic Goto-Kakizaki rats

(2010) Zhengtang Qi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Brain Microglial Cytokines in Neurogenic Hypertension

(2010) Peng Shi et al.   HYPERTENSION

Muscles and their myokines

(2010) B. K. Pedersen   JOURNAL OF EXPERIMENTAL BIOLOGY

Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

(2010) Dan Shlosberg et al.   Nature Reviews Neurology

Adrenoceptors in brain: Cellular gene expression and effects on astrocytic metabolism and [Ca2+]i

(2010) Leif Hertz et al.   NEUROCHEMISTRY INTERNATIONAL

Glycogen metabolism: Metabolic coupling between astrocytes and neurons

(2010) E. E. Benarroch   NEUROLOGY

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry

(2010) Å. Konradsson-Geuken et al.   NEUROSCIENCE

Angiotensin II induced cerebral microvascular inflammation and increased blood–brain barrier permeability via oxidative stress

(2010) M. Zhang et al.   NEUROSCIENCE

Aerobic Exercise and Neurocognitive Performance: A Meta-Analytic Review of Randomized Controlled Trials

(2010) Patrick J. Smith et al.   PSYCHOSOMATIC MEDICINE

Metabolic Signatures of Exercise in Human Plasma

(2010) G. D. Lewis et al.   Science Translational Medicine

Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training

(2010) Karsten Lenk et al.   Journal of Cachexia Sarcopenia and Muscle

Aerobic versus resistance exercise training in modulation of insulin resistance, adipocytokines and inflammatory cytokine levels in obese type 2 diabetic patients

(2010) Shehab M. Abd El-Kader   Journal of Advanced Research

Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis

(2009) Ruchika Shaurya Prakash et al.   BRAIN RESEARCH

Chronic endurance exercise training prevents aging-related cognitive decline in healthy older adults: a randomized controlled trial

(2009) Antonio Muscari et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Blood Lactate is an Important Energy Source for the Human Brain

(2009) Gerrit van Hall et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lack of adequate appreciation of physical exercise's complexities can pre-empt appropriate design and interpretation in scientific discovery

(2009) F. W. Booth et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitis

(2009) Silvia Rossi et al.   NEUROBIOLOGY OF DISEASE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Exercise and Brain Health – Implications for Multiple Sclerosis

(2009) Lesley J White et al.   SPORTS MEDICINE

The neurovascular link in health and disease: an update

(2009) Inmaculada Segura et al.   TRENDS IN MOLECULAR MEDICINE

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

The blood-brain barrier in brain homeostasis and neurological diseases

(2008) Nicolas Weiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

(2008) Srijan Sen et al.   BIOLOGICAL PSYCHIATRY

Alzheimer’s disease, cerebrovascular dysfunction and the benefits of exercise: From vessels to neurons

(2008) Christian Lange-Asschenfeldt et al.   EXPERIMENTAL GERONTOLOGY

Serum brain-derived neurotrophic factor response to aerobic exercise in multiple sclerosis

(2008) Vanessa Castellano et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The role of exercise and PGC1α in inflammation and chronic disease

(2008) Christoph Handschin et al.   NATURE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

The Neurovascular Unit in Health and Disease: Introduction

(2008) E. H. Lo et al.   STROKE

Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling

(2007) Li Li Ji   FREE RADICAL BIOLOGY AND MEDICINE

Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training

(2007) Mari-Carmen Gomez-Cabrera et al.   FREE RADICAL BIOLOGY AND MEDICINE

Noradrenergic stimulation of BDNF synthesis in astrocytes: Mediation via α1- and β1/β2-adrenergic receptors

(2007) Damijana Mojca Jurič et al.   NEUROCHEMISTRY INTERNATIONAL