Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting

Uncoupling of the ITIM receptor G6b-B from the tyrosine phosphatases Shp1 and Shp2 disrupts platelet homeostasis in mice

(2018) Mitchell J. Geer et al.   BLOOD

Relevance of N-terminal residues for amyloid-β binding to platelet integrin α IIb β 3 , integrin outside-in signaling and amyloid-β fibril formation

(2018) Lili Donner et al.   CELLULAR SIGNALLING

Clinical and molecular insights into Glanzmann's thrombasthenia in China

(2018) L. Zhou et al.   CLINICAL GENETICS

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

(2018) Jianlin Qiao et al.   HAEMATOLOGICA

Mucor circinelloides induces platelet aggregation through integrin αIIbβ3 and FcγRIIA

(2018) Harlene Ghuman et al.   PLATELETS

A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y 12 receptor in platelets

(2018) Mohammed Makkawi et al.   THROMBOSIS RESEARCH

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

(2018) Jianlin Qiao et al.   HAEMATOLOGICA

Recent progress and market analysis of anticoagulant drugs

(2018) Ping Fan et al.   Journal of Thoracic Disease

Impact of PI3Kα (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis

(2018) Pierre-Alexandre Laurent et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Short Half-Life αIIbβ3 Antagonist ANTP266 Reduces Thrombus Formation

(2018) Tong-Dan Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interaction Analyses of 14-3-3ζ, Dok1, and Phosphorylated Integrin β Cytoplasmic Tails Reveal a Bi-molecular Switch in Integrin Regulation

(2018) Deepak Chatterjee et al.   JOURNAL OF MOLECULAR BIOLOGY

The transmembrane protein disulfide isomerase TMX1 negatively regulates platelet responses

(2018) Zhenzhen Zhao et al.   BLOOD

Platelet Shp2 negatively regulates thrombus stability under high shear stress

(2018) M. Hu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies

(2017) Magdolna Nagy et al.   HAEMATOLOGICA

Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin

(2017) Juan Gao et al.   JOURNAL OF CELL SCIENCE

PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signaling and platelet function through up-regulation of protein kinase A activity

(2017) A. J. Unsworth et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural basis of kindlin-mediated integrin recognition and activation

(2017) Huadong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology

(2017) Peng Wang et al.   Science China-Life Sciences

Platelet receptors as therapeutic targets: Past, present and future

(2017) Janina Jamasbi et al.   THROMBOSIS AND HAEMOSTASIS

Palladin is involved in platelet activation and arterial thrombosis

(2017) Xuejiao Chen et al.   THROMBOSIS RESEARCH

Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation

(2017) Liang Zhu et al.   Nature Communications

Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies

(2017) Magdolna Nagy et al.   HAEMATOLOGICA

Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target?

(2017) Marion Lavergne et al.   Cancers

Binding of CIB1 to the αIIb tail of αIIbβ3 is required for FAK recruitment and activation in platelets

(2017) Meghna U. Naik et al.   PLoS One

Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation

(2017) Klytaimnistra Kiouptsi et al.   Scientific Reports

Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on HemostasisHighlights

(2016) Raymond Piatt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Human CalDAG-GEFI deficiency increases bleeding and delays  IIb 3 activation

(2016) H. Kato et al.   BLOOD

Effects Of Glycoprotein IIb/IIIa Antagonists: Anti Platelet Aggregation And Beyond

(2016) Arturo Giordano et al.   CURRENT DRUG METABOLISM

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3Outside-in Signaling

(2016) Anthony M. Battram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in αIIbβ3Integrin Signaling

(2016) Tanvir Khatlani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The kindlin family: functions, signaling properties and implications for human disease

(2016) Emanuel Rognoni et al.   JOURNAL OF CELL SCIENCE

Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice

(2016) M. Niki et al.   THROMBOSIS AND HAEMOSTASIS

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

(2016) Marina Theodosiou et al.   eLife

Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice

(2015) S. Klapproth et al.   BLOOD

Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and HemostasisClinical Perspective

(2015) Binggang Xiang et al.   CIRCULATION

Platelet GP IIb-IIIa Receptor Antagonists in Primary Angioplasty: Back to the Future

(2015) Giuseppe De Luca et al.   DRUGS

Homozygous loss of mouse tetraspanin CD82 enhances integrin αIIbβ3 expression and clot retraction in platelets

(2015) Kristen Uchtmann et al.   EXPERIMENTAL CELL RESEARCH

Progress in the research of GPIIb/IIIa antagonists

(2015) Zhouling Xie et al.   Future Medicinal Chemistry

Gα13Switch Region 2 Binds to the Talin Head Domain and Activates αIIbβ3 Integrin in Human Platelets

(2015) Subhashini Srinivasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation

(2015) Rudy E. Fuentes et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of targeting c-Src by the RGT-containing peptide as a novel antithrombotic strategy

(2015) Jiansong Huang et al.   Journal of Hematology & Oncology

Structural mechanism of integrin inactivation by filamin

(2015) Jianmin Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A complementary role for tetraspanin superfamily member CD151 and ADP purinergic P2Y12 receptor in platelets

(2015) Mohammed Makkawi et al.   THROMBOSIS AND HAEMOSTASIS

A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration

(2015) Frederic Lagarrigue et al.   Nature Communications

Structural mechanism of integrin inactivation by filamin

(2015) Jianmin Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Integrin activation

(2015) Mark H. Ginsberg   BMB Reports

Mice Lacking the SLAM Family Member CD84 Display Unaltered Platelet Function in Hemostasis and Thrombosis

(2015) Sebastian Hofmann et al.   PLoS One

The β3-Integrin Binding Protein β3-Endonexin Is a Novel Negative Regulator of Hypoxia-Inducible Factor-1

(2014) Damir Kračun et al.   ANTIOXIDANTS & REDOX SIGNALING

Disabled-2 Is Required for Efficient Hemostasis and Platelet Activation by Thrombin in Mice

(2014) Hui-Ju Tsai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet Endothelial Cell Adhesion Molecule-1 Inhibits Platelet Response to Thrombin and von Willebrand Factor by Regulating the Internalization of Glycoprotein Ib via AKT/Glycogen Synthase Kinase-3/Dynamin and Integrin αIIbβ3

(2014) Chris I. Jones et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice

(2014) S. Stritt et al.   BLOOD

ADAP interactions with talin and kindlin promote platelet integrin  IIb 3 activation and stable fibrinogen binding

(2014) A. Kasirer-Friede et al.   BLOOD

Platelet PI3K  and GSK3 regulate thrombus stability at a high shear rate

(2014) P.-A. Laurent et al.   BLOOD

A talin mutant that impairs talin-integrin binding in platelets decelerates  IIb 3 activation without pathological bleeding

(2014) L. Stefanini et al.   BLOOD

Src family kinases: at the forefront of platelet activation

(2014) Y. A. Senis et al.   BLOOD

Towards Effective and Safe Thrombolysis and Thromboprophylaxis

(2014) Xiaowei Wang et al.   CIRCULATION RESEARCH

Dok-2 Adaptor Protein Regulates the Shear-dependent Adhesive Function of Platelet Integrin αIIbβ3in Mice

(2014) Sascha C. Hughan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis of Kindlin-2 Binding to Integrin-linked Kinase Pseudokinase for Regulating Cell Adhesion

(2014) Koichi Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation

(2014) C. Huet-Calderwood et al.   JOURNAL OF CELL SCIENCE

Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi

(2014) C. I. Jones et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Talin and kindlin: the one-two punch in integrin activation

(2014) Feng Ye et al.   Frontiers of Medicine

Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?

(2013) J. D. Hohmann et al.   BLOOD

Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the  IIb 3 integrin

(2013) L. Wang et al.   BLOOD

PDK1 regulates platelet activation and arterial thrombosis

(2013) X. Chen et al.   BLOOD

Junctional adhesion molecule-A suppresses platelet integrin  IIb 3 signaling by recruiting Csk to the integrin-c-Src complex

(2013) M. U. Naik et al.   BLOOD

A directional switch of integrin signalling and a new anti-thrombotic strategy

(2013) Bo Shen et al.   NATURE

Impaired thrombin-induced platelet activation and thrombus formation in mice lacking the Ca2+-dependent tyrosine kinase Pyk2

(2012) I. Canobbio et al.   BLOOD

JAM-A protects from thrombosis by suppressing integrin  IIb 3-dependent outside-in signaling in platelets

(2012) M. U. Naik et al.   BLOOD

Agonist stimulation, talin-1, and kindlin-3 are crucial for αIIbβ3 activation in a human megakaryoblastic cell line, CMK

(2012) Tsuyoshi Nakazawa et al.   EXPERIMENTAL HEMATOLOGY

Spatial Coordination of Kindlin-2 with Talin Head Domain in Interaction with Integrin β Cytoplasmic Tails

(2012) Kamila Bledzka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct and overlapping functional roles of Src family kinases in mouse platelets

(2012) S. SÉVERIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling

(2012) L. Cipolla et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mice Lacking the ITIM-Containing Receptor G6b-B Exhibit Macrothrombocytopenia and Aberrant Platelet Function

(2012) A. Mazharian et al.   Science Signaling

Structure-Guided Design of a High-Affinity Platelet Integrin  IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS

(2012) J. Zhu et al.   Science Translational Medicine

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Novel and Recurrent FERMT1 Gene Mutations in Kindler Syndrome

(2011) JA McGrath et al.   ACTA DERMATO-VENEREOLOGICA

Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signaling

(2011) L. Buitrago et al.   BLOOD

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

(2011) I. Pleines et al.   BLOOD

The integrin coactivator Kindlin-2 plays a critical role in angiogenesis in mice and zebrafish

(2011) E. Pluskota et al.   BLOOD

Heparin promotes platelet responsiveness by potentiating  IIb 3-mediated outside-in signaling

(2011) C. Gao et al.   BLOOD

Optimal Use of Platelet Glycoprotein IIb/IIIa Receptor Antagonists in Patients Undergoing Percutaneous Coronary Interventions

(2011) H. Benjamin Starnes et al.   DRUGS

Molecular mechanism of inside-out integrin regulation

(2011) F. YE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation

(2011) Huzoor Akbar et al.   PLoS One

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Signaling During Platelet Adhesion and Activation

(2010) Zhenyu Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vinculin activates inside-out signaling of integrin αIIbβ3 in Chinese hamster ovary cells

(2010) Tsukasa Ohmori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D

(2010) K. M. Wannemacher et al.   BLOOD

A potential role for  -actinin in inside-out  IIb 3 signaling

(2010) S. Tadokoro et al.   BLOOD

PTEN regulates collagen-induced platelet activation

(2010) Z. Weng et al.   BLOOD

Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro

(2010) A. McDowall et al.   BLOOD

Talin-dependent integrin activation is required for fibrin clot retraction by platelets

(2010) J. R. Haling et al.   BLOOD

Tyrosine Phosphorylation of Integrin β3Regulates Kindlin-2 Binding and Integrin Activation

(2010) Kamila Bledzka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Integrin Co-activator Kindlin-3 Is Expressed and Functional in a Non-hematopoietic Cell, the Endothelial Cell

(2010) Katarzyna Bialkowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Important Role of the Src Family Kinase Lyn in Stimulating Platelet Granule Secretion

(2010) Zhenyu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin β3Phosphorylation Dictates Its Complex with the Shc Phosphotyrosine-binding (PTB) Domain

(2010) Lalit Deshmukh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recreation of the terminal events in physiological integrin activation

(2010) Feng Ye et al.   JOURNAL OF CELL BIOLOGY

What is vinculin needed for in platelets?

(2010) J. V. MITSIOS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization

(2010) J. M. E. M. COSEMANS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

G Protein Subunit G 13 Binds to Integrin  IIb 3 and Mediates Integrin "Outside-In" Signaling

(2010) H. Gong et al.   SCIENCE

Relation of Periprocedural Bleeding Complications and Long-Term Outcome in Patients Undergoing Percutaneous Coronary Revascularization (from the Evaluation of Oral Xemilofiban in Controlling Thrombotic Events [EXCITE] Trial)

(2009) Jasper Jan Brugts et al.   AMERICAN JOURNAL OF CARDIOLOGY

Protein Kinase Cδ Differentially Regulates Platelet Functional Responses

(2009) Ramya Chari et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role for ADAP in shear flow-induced platelet mechanotransduction

(2009) A. Kasirer-Friede et al.   BLOOD

Integrin-linked kinase associated with integrin activation

(2009) S. Honda et al.   BLOOD

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

(2009) Y. A. Senis et al.   BLOOD

A novel 3017-bp deletion mutation in theFERMT1(KIND1) gene in a Chinese family with Kindler syndrome

(2009) C. Zhou et al.   BRITISH JOURNAL OF DERMATOLOGY

WASP plays a novel role in regulating platelet responses dependent on αIIbβ3 integrin outside-in signalling

(2009) Anna Shcherbina et al.   BRITISH JOURNAL OF HAEMATOLOGY

Reelin is a platelet protein and functions as a positive regulator of platelet spreading on fibrinogen

(2009) Wei-Lien Tseng et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

(2009) Nicholas J Anthis et al.   EMBO JOURNAL

The role of kindlins in cell biology and relevance to human disease

(2009) J.E. Lai-Cheong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation

(2009) Nicholas J. Anthis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kindlin-1 and -2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects

(2009) David S. Harburger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms that regulate adaptor binding to  -integrin cytoplasmic tails

(2009) K. R. Legate et al.   JOURNAL OF CELL SCIENCE

Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo

(2009) Hitoshi Takizawa et al.   JOURNAL OF CLINICAL INVESTIGATION

The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation

(2009) Benjamin T. Goult et al.   JOURNAL OF MOLECULAR BIOLOGY

CD9 negatively regulates integrin αIIbβ3activation and could thus prevent excessive platelet recruitment at sites of vascular injury

(2009) P. H. MANGIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation

(2009) M. T. HARPER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Calcium signaling in platelets

(2009) D. VARGA-SZABO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A platelet tetraspanin superfamily member, CD151, is required for regulation of thrombus growth and stabilityin vivo

(2009) E. ORLOWSKI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial cell specific adhesion molecule (ESAM) localizes to platelet–platelet contacts and regulates thrombus formationin vivo

(2009) T. J. STALKER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin αIIbβ3

(2009) M. U. NAIK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Integrins in platelet activation

(2009) B. NIESWANDT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

The Catalytic Subunit of Protein Phosphatase 1 Gamma Regulates Thrombin-Induced Murine Platelet αIIbβ3 Function

(2009) Francisca C. Gushiken et al.   PLoS One

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

The Kindlin protein family: new members to the club of focal adhesion proteins

(2009) Alexander Meves et al.   TRENDS IN CELL BIOLOGY

Antithrombotic effects of targeting  IIb 3 signaling in platelets

(2008) A. J. Ablooglu et al.   BLOOD

Identification of Fc RIIa as the ITAM-bearing receptor mediating  IIb 3 outside-in integrin signaling in human platelets

(2008) B. Boylan et al.   BLOOD

A dual role for integrin-linked kinase in platelets: regulating integrin function and  -granule secretion

(2008) K. L. Tucker et al.   BLOOD

CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo

(2008) C. Wong et al.   BLOOD

LAD-1/variant syndrome is caused by mutations inFERMT3

(2008) Taco W. Kuijpers et al.   BLOOD

Group IVA cytosolic phospholipase A2 (cPLA2 ) and integrin  IIb 3 reinforce each other's functions during  IIb 3 signaling in platelets

(2008) N. Prevost et al.   BLOOD

UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin  IIb 3

(2008) R. Verhaar et al.   BLOOD

RGT, a synthetic peptide corresponding to the integrin  3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin  IIb 3 with Src kinase

(2008) X. Su et al.   BLOOD

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin  IIb 3 in platelets

(2008) S. M. Cifuni et al.   BLOOD

Kindlin-2 Is an Essential Component of Intercalated Discs and Is Required for Vertebrate Cardiac Structure and Function

(2008) James J. Dowling et al.   CIRCULATION RESEARCH

Kindlin-2 controls bidirectional signaling of integrins

(2008) E. Montanez et al.   GENES & DEVELOPMENT

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3

(2008) Naohide Watanabe et al.   JOURNAL OF CELL BIOLOGY

Kindlin-2 (Mig-2): a co-activator of β3integrins

(2008) Yan-Qing Ma et al.   JOURNAL OF CELL BIOLOGY

Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin αIIbβ3

(2008) Timothy A. Springer et al.   JOURNAL OF CELL BIOLOGY

Analysis of Fyn function in hemostasis and  IIb 3-integrin signaling

(2008) K. B. Reddy et al.   JOURNAL OF CELL SCIENCE

Structural Basis for the Interaction between the Cytoplasmic Domain of the Hyaluronate Receptor Layilin and the Talin F3 Subdomain

(2008) Kate L. Wegener et al.   JOURNAL OF MOLECULAR BIOLOGY

Deficiency of the Tetraspanin CD63 Associated with Kidney Pathology but Normal Lysosomal Function

(2008) J. Schroder et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

(2008) Esen Goksoy et al.   MOLECULAR CELL

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

Rac1 is essential for phospholipase C-γ2 activation in platelets

(2008) Irina Pleines et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Genetic Analysis of the Role of Protein Kinase Cθ in Platelet Function and Thrombus Formation

(2008) Kellie J. Hall et al.   PLoS One

Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: Potential compensation by CIB family members

(2008) Brenda R. Temple et al.   THROMBOSIS AND HAEMOSTASIS