NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology

Effect of Methylation on Local Mechanics and Hydration Structure of DNA

(2018) Xiaojing Teng et al.   BIOPHYSICAL JOURNAL

A polarized view on DNA under tension

(2018) Joost van Mameren et al.   JOURNAL OF CHEMICAL PHYSICS

αβ T Cell Receptor Mechanosensing Forces out Serial Engagement

(2018) Yinnian Feng et al.   TRENDS IN IMMUNOLOGY

Mixed pyruvate labeling enables backbone resonance assignment of large proteins using a single experiment

(2018) Scott A. Robson et al.   Nature Communications

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

(2018) Leah V. Sibener et al.   CELL

Peptide–MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites

(2018) Sneha Rangarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimal control theory enables homonuclear decoupling without Bloch–Siegert shifts in NMR spectroscopy

(2018) Paul W. Coote et al.   Nature Communications

The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations

(2018) Kristine N. Brazin et al.   IMMUNITY

NMR-directed design of pre-TCRβ and pMHC molecules implies a distinct geometry for pre-TCR relative to αβTCR recognition of pMHC

(2017) Robert J. Mallis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variable Regions of Antibodies and T-Cell Receptors May Not Be Sufficient in Molecular Simulations Investigating Binding

(2017) Bernhard Knapp et al.   Journal of Chemical Theory and Computation

Automatic Assignment of Methyl-NMR Spectra of Supramolecular Machines Using Graph Theory

(2017) Iva Pritišanac et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Probing the cooperativity ofThermoplasma acidophilumproteasome core particle gating by NMR spectroscopy

(2017) Rui Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanosensing drives acuity ofαβT-cell recognition

(2017) Yinnian Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudocontact shifts in biomolecular NMR using paramagnetic metal tags

(2017) Christoph Nitsche et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role

(2017) Kannan Natarajan et al.   Nature Communications

Kinesin motility driven by subdomain dynamics

(2017) Wonmuk Hwang et al.   eLife

Pre-T Cell Receptors (Pre-TCRs) Leverage Vβ Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands

(2016) Dibyendu Kumar Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pseudocontact Shift-Driven Iterative Resampling for 3D Structure Determinations of Large Proteins

(2016) Kala Bharath Pilla et al.   JOURNAL OF MOLECULAR BIOLOGY

A conserved αβ transmembrane interface forms the core of a compact T-cell receptor–CD3 structure within the membrane

(2016) Logesvaran Krshnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Model of the Extracellular Assembly of the TCR-CD3 Complex

(2016) Aswin Natarajan et al.   Cell Reports

Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse

(2016) William A. Comrie et al.   Frontiers in Immunology

Backbone resonance assignment of N15, N30 and D10 T cell receptor β subunits

(2015) Robert J. Mallis et al.   Biomolecular NMR Assignments

Methyl-specific isotopic labeling: a molecular tool box for solution NMR studies of large proteins

(2015) Rime Kerfah et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR

(2015) Yanan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY

(2015) Alexander G. Milbradt et al.   JOURNAL OF BIOMOLECULAR NMR

CH3-specific NMR assignment of alanine, isoleucine, leucine and valine methyl groups in high molecular weight proteins using a single sample

(2015) Rime Kerfah et al.   JOURNAL OF BIOMOLECULAR NMR

Nanoscale optomechanical actuators for controlling mechanotransduction in living cells

(2015) Zheng Liu et al.   NATURE METHODS

Pre-TCR ligand binding impacts thymocyte development before αβTCR expression

(2015) Robert J. Mallis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

(2015) Dibyendu Kumar Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination

(2015) Kristine N. Brazin et al.   Frontiers in Immunology

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Constitutively Oxidized CXXC Motifs within the CD3 Heterodimeric Ectodomains of the T Cell Receptor Complex Enforce the Conformation of Juxtaposed Segments

(2014) Kristine N. Brazin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A 3D time-shared NOESY experiment designed to provide optimal resolution for accurate assignment of NMR distance restraints in large proteins

(2014) Subrata H. Mishra et al.   JOURNAL OF BIOMOLECULAR NMR

Molecular architecture of the αβ T cell receptor–CD3 complex

(2014) Michael E. Birnbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large Scale Characterization of the LC13 TCR and HLA-B8 Structural Landscape in Reaction to 172 Altered Peptide Ligands: A Molecular Dynamics Simulation Study

(2014) Bernhard Knapp et al.   PLoS Computational Biology

Probing Slow Chemical Exchange at Carbonyl Sites in Proteins by Chemical Exchange Saturation Transfer NMR Spectroscopy

(2013) Pramodh Vallurupalli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure determination of protein–protein complexes with long-range anisotropic paramagnetic NMR restraints

(2013) Mathias AS Hass et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells

(2013) Adrienne M. Luoma et al.   IMMUNITY

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide–MHC

(2013) John A.H. Hoerter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stiffened lipid platforms at molecular force foci

(2013) A. Anishkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function

(2012) Jia-huai Wang et al.   IMMUNOLOGICAL REVIEWS

Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

(2012) Etienne Gagnon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Studying “Invisible” Excited Protein States in Slow Exchange with a Major State Conformation

(2012) Pramodh Vallurupalli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution NMR spectroscopy of supra-molecular systems, why bother? A methyl-TROSY view

(2011) Lewis E. Kay   JOURNAL OF MAGNETIC RESONANCE

Crystal structure of a    T-cell receptor specific for the human MHC class I homolog MICA

(2011) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR Dimerization

(2011) Bo Zhou et al.   Frontiers in Immunology

Direct Comparison of Dll1- and Dll4-Mediated Notch Activation Levels Shows Differential Lymphomyeloid Lineage Commitment Outcomes

(2010) M. Mohtashami et al.   JOURNAL OF IMMUNOLOGY

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

(2010) Siew Siew Pang et al.   NATURE

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Time-shared HSQC-NOESY for accurate distance constraints measured at high-field in 15N-13C-ILV methyl labeled proteins

(2009) Dominique P. Frueh et al.   JOURNAL OF BIOMOLECULAR NMR

Characterization of Enzyme Motions by Solution NMR Relaxation Dispersion

(2008) J. Patrick Loria et al.   ACCOUNTS OF CHEMICAL RESEARCH

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Immunodominant-Peptide Recognition: Beta Testing TCRαβ

(2008) Jia-huai Wang et al.   IMMUNITY

See me, feel me: methods to concurrently visualize and manipulate single DNA molecules and associated proteins

(2008) J. van Mameren et al.   NUCLEIC ACIDS RESEARCH