Hydrogel materials for the application of islet transplantation

Construction of EMSC-islet co-localizing composites for xenogeneic porcine islet transplantation

(2018) Jung-Sik Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antifibrotic Effect of Ketoprofen-Grafted Alginate Microcapsules in the Transplantation of Insulin Producing Cells

(2018) François Noverraz et al.   BIOCONJUGATE CHEMISTRY

Design of a vascularized synthetic poly(ethylene glycol) macroencapsulation device for islet transplantation

(2018) Jessica D. Weaver et al.   BIOMATERIALS

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges

(2018) Julie B. Sneddon et al.   Cell Stem Cell

Local, Controlled Release In Vivo of Vascular Endothelial Growth Factor Within a Subcutaneous Scaffolded Islet Implant Reduces Early Islet Necrosis and Improves Performance of the Graft

(2018) John A. Gebe et al.   CELL TRANSPLANTATION

Silk fibroin preserves beta cell function under inflammatory stress while stimulating islet cell surface GLUT2 expression

(2018) N. Ashari et al.   CELLULAR IMMUNOLOGY

Endothelial cell regulation through epigenetic mechanisms: Depicting parallels and its clinical application within an intra-islet microenvironment

(2018) Siddharth Narayanan et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets

(2018) L. Alberto Llacua et al.   DIABETOLOGIA

Tunable injectable alginate-based hydrogel for cell therapy in Type 1 Diabetes Mellitus

(2018) Albert Espona-Noguera et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Culturing functional pancreatic islets on α5-laminins and curative transplantation to diabetic mice

(2018) Kristmundur Sigmundsson et al.   MATRIX BIOLOGY

Human mesenchymal-stem-cells-derived exosomes are important in enhancing porcine islet resistance to hypoxia

(2018) Wei Nie et al.   XENOTRANSPLANTATION

Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply

(2018) Yoav Evron et al.   Scientific Reports

The rat pancreatic body tail as a source of a novel extracellular matrix scaffold for endocrine pancreas bioengineering

(2018) Huajun Yu et al.   Journal of Biological Engineering

Tolerance induction by surface immobilization of Jagged-1 for immunoprotection of pancreatic islets

(2018) Zhila Izadi et al.   BIOMATERIALS

Immunomodulatory injectable silk hydrogels maintaining functional islets and promoting anti-inflammatory M2 macrophage polarization

(2018) Manishekhar Kumar et al.   BIOMATERIALS

A Novel Subcutaneous Pancreatic Islet Transplantation Method Using the New Device of Recombinant Peptide Containing Human Type I Collagen Material with RGD motif (Arg-Gly-Asp)

(2018) Satomi Uematsu et al.   TRANSPLANTATION

Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas

(2018) Sara Dutton Sackett et al.   Scientific Reports

Therapeutic potential of Mesenchymal Stem Cells for the treatment of diabetic peripheral neuropathy

(2017) Marianna Monfrini et al.   EXPERIMENTAL NEUROLOGY

Xenotransplantation of layer-by-layer encapsulated non-human primate islets with a specified immunosuppressive drug protocol

(2017) Muhammad R. Haque et al.   JOURNAL OF CONTROLLED RELEASE

Synthetic hydrogels mimicking basement membrane matrices to promote cell-matrix interactions

(2017) Ricardo Cruz-Acuña et al.   MATRIX BIOLOGY

Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes

(2017) Duo An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular tissue engineering for the vascularization of subcutaneously transplanted pancreatic islets

(2017) Alexander E. Vlahos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyaluronic Acid/Collagen Hydrogel as an Alternative to Alginate for Long-Term Immunoprotected Islet Transplantation

(2017) Stephen Harrington et al.   TISSUE ENGINEERING PART A

Co-encapsulation and co-transplantation of mesenchymal stem cells reduces pericapsular fibrosis and improves encapsulated islet survival and function when allografted

(2017) Vijayaganapathy Vaithilingam et al.   Scientific Reports

Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites

(2017) Jessica D. Weaver et al.   Science Advances

The Human Pancreas as a Source of Protolerogenic Extracellular Matrix Scaffold for a New-generation Bioartificial Endocrine Pancreas

(2016) Andrea Peloso et al.   ANNALS OF SURGERY

Silk matrices promote formation of insulin-secreting islet-like clusters

(2016) Nancy Dekki Shalaly et al.   BIOMATERIALS

Sustained release of hepatocyte growth factor by cationic self-assembling peptide/heparin hybrid hydrogel improves β-cell survival and function through modulating inflammatory response

(2016) Jingping Liu et al.   International Journal of Nanomedicine

Extracellular matrix components supporting human islet function in alginate-based immunoprotective microcapsules for treatment of diabetes

(2016) Alberto Llacua et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

(2016) Arturo J Vegas et al.   NATURE BIOTECHNOLOGY

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

Modified alginates provide a long-term disguise against the foreign body response

(2016) Natasha Bray   NATURE REVIEWS DRUG DISCOVERY

Clinical pancreatic islet transplantation

(2016) A. M. James Shapiro et al.   Nature Reviews Endocrinology

Long-term Efficacy and Biocompatibility of Encapsulated Islet Transplantation With Chitosan-Coated Alginate Capsules in Mice and Canine Models of Diabetes

(2016) Hae Kyung Yang et al.   TRANSPLANTATION

Collagen V Is a Potential Substrate for Clostridial Collagenase G in Pancreatic Islet Isolation

(2016) Hiroki Shima et al.   Journal of Diabetes Research

Developing robust, hydrogel-based, nanofiber-enabled encapsulation devices (NEEDs) for cell therapies

(2015) Duo An et al.   BIOMATERIALS

Processing silk hydrogel and its applications in biomedical materials

(2015) Hai-Yan Wang et al.   BIOTECHNOLOGY PROGRESS

Functionalized self-assembling peptide improves INS-1 β-cell function and proliferation via the integrin/FAK/ERK/cyclin pathway

(2015) Jingping Liu et al.   International Journal of Nanomedicine

A silk-based encapsulation platform for pancreatic islet transplantation improves islet function in vivo

(2015) Diana C. Hamilton et al.   Journal of Tissue Engineering and Regenerative Medicine

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

(2015) Omid Veiseh et al.   NATURE MATERIALS

Fibrin, a Scaffold Material for Islet Transplantation and Pancreatic Endocrine Tissue Engineering

(2015) Matthew Riopel et al.   TISSUE ENGINEERING PART B-REVIEWS

Coaggregates of Regulatory T Cells and Islet Cells Allow Long-term Graft Survival in Liver Without Immunosuppression

(2015) Naohiro Takemoto et al.   TRANSPLANTATION

Insights in Behavior of Variably Formulated Alginate-Based Microcapsules for Cell Transplantation

(2015) Pia Montanucci et al.   Biomed Research International

Pancreatic Islet Survival and Engraftment Is Promoted by Culture on Functionalized Spider Silk Matrices

(2015) Ulrika Johansson et al.   PLoS One

Local Co-Delivery of Pancreatic Islets and Liposomal Clodronate Using Injectable Hydrogel to Prevent Acute Immune Reactions in a Type 1 Diabetes

(2014) Muhammad R. Haque et al.   PHARMACEUTICAL RESEARCH

Designer self-assembling hydrogel scaffolds can impact skin cell proliferation and migration

(2014) Michael Bradshaw et al.   Scientific Reports

Encapsulated islets for diabetes therapy: History, current progress, and critical issues requiring solution

(2013) David W. Scharp et al.   ADVANCED DRUG DELIVERY REVIEWS

Recombinant spider silk with cell binding motifs for specific adherence of cells

(2013) Mona Widhe et al.   BIOMATERIALS

Co-transplantation of islets with mesenchymal stem cells in microcapsules demonstrates graft outcome can be improved in an isolated-graft model of islet transplantation in mice

(2013) Alan Kerby et al.   CYTOTHERAPY

Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient

(2013) D. Jacobs-Tulleneers-Thevissen et al.   DIABETOLOGIA

Probing cellular heterogeneity in cytokine-secreting immune cells using droplet-based microfluidics

(2013) Venkatachalam Chokkalingam et al.   LAB ON A CHIP

Self-assembling functionalized nanopeptides for immediate hemostasis and accelerative liver tissue regeneration

(2013) Tzu-Yun Cheng et al.   Nanoscale

Evaluation of a Collagen-Chitosan Hydrogel for Potential Use as a Pro-Angiogenic Site for Islet Transplantation

(2013) Joanne E. McBane et al.   PLoS One

Engineered VEGF-releasing PEG–MAL hydrogel for pancreatic islet vascularization

(2013) Edward A. Phelps et al.   Drug Delivery and Translational Research

Enhanced function of pancreatic islets co-encapsulated with ECM proteins and mesenchymal stromal cells in a silk hydrogel

(2012) Nicolynn E. Davis et al.   BIOMATERIALS

Reversal of Diabetes in Mice with a Bioengineered Islet Implant Incorporating a Type I Collagen Hydrogel and Sustained Release of Vascular Endothelial Growth Factor

(2012) Robert B. Vernon et al.   CELL TRANSPLANTATION

Highly stretchable and tough hydrogels

(2012) Jeong-Yun Sun et al.   NATURE

Synergistic Effect of Surface Modification With Poly(ethylene glycol) and Immunosuppressants on Repetitive Pancreatic Islet Transplantation Into Antecedently Sensitized Rat

(2012) J.-H. Jeong et al.   TRANSPLANTATION PROCEEDINGS

Survival of human islets in microbeads containing high guluronic acid alginate crosslinked with Ca2+and Ba2+

(2012) Meirigeng Qi et al.   XENOTRANSPLANTATION

Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation

(2012) Minglin Ma et al.   Advanced Healthcare Materials

Design of self-assembling peptides and their biomedical applications

(2011) Jingping Liu et al.   Nanomedicine

Cell-cell communication mimicry with poly(ethylene glycol) hydrogels for enhancing  -cell function

(2011) C.-C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alginate: Properties and biomedical applications

(2011) Kuen Yong Lee et al.   PROGRESS IN POLYMER SCIENCE

Bioartificial pancreas☆Microencapsulation and conformal coating of islet of Langerhans

(2010) Yuji Teramura et al.   ADVANCED DRUG DELIVERY REVIEWS

Immobilization of the soluble domain of human complement receptor 1 on agarose-encapsulated islets for the prevention of complement activation

(2010) Nguyen Minh Luan et al.   BIOMATERIALS

Silk-based materials for biomedical applications

(2010) Aldo Leal‑Egaña et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Self-Assembly-Peptide Hydrogels as Tissue-Engineering Scaffolds for Three-Dimensional Culture of Chondrocytes in vitro

(2010) Jingping Liu et al.   MACROMOLECULAR BIOSCIENCE

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

Mesenchymal Stem Cell and Islet Co-Transplantation Promotes Graft Revascularization and Function

(2010) Taihei Ito et al.   TRANSPLANTATION

Glucagon-Like Peptide-1 Functionalized PEG Hydrogels Promote Survival and Function of Encapsulated Pancreatic β-Cells

(2009) Chien-Chi Lin et al.   BIOMACROMOLECULES

Biodegradation of Silk Biomaterials

(2009) Yang Cao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Effects of PEG hydrogel crosslinking density on protein diffusion and encapsulated islet survival and function

(2008) Laney M. Weber et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Islet-Like Clusters Derived from Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord for Transplantation to Control Type 1 Diabetes

(2008) Kuo Ching Chao et al.   PLoS One