The metastasis suppressor NDRG1 down-regulates the epidermal growth factor receptor via a lysosomal mechanism by up-regulating mitogen-inducible gene 6

Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1

(2018) Kyung Chan Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Proteomics reveals novel protein associations with early endosomes in an epidermal growth factor–dependent manner

(2018) Julie A. Gosney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vitro assessment of the role of DpC in the treatment of head and neck squamous cell carcinoma

(2018) Ye‑Xing Xu et al.   Oncology Letters

The Metastasis Suppressor, NDRG1, Attenuates Oncogenic TGF-β and NF-ĸB Signaling to Enhance Membrane E-Cadherin Expression in Pancreatic Cancer Cells

(2018) Sharleen V Menezes et al.   CARCINOGENESIS

Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling

(2017) Sharleen V. Menezes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen–Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1)

(2017) Ruxing Xi et al.   MOLECULAR PHARMACOLOGY

On the origin of shape fluctuations of the cell nucleus

(2017) Fang-Yi Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms

(2016) Zhu-Ling Guo et al.   Journal of Hematology & Oncology

Structure–Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance

(2016) Alexandra E. Stacy et al.   JOURNAL OF MEDICINAL CHEMISTRY

PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7

(2016) Swapnil Rohidas Shinde et al.   Nature Communications

Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter

(2015) Nicole A. Seebacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways

(2015) Zaklina Kovacevic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6

(2015) Eunyoung Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the “Triad of Death” in cancer by Di-2-pyridylketone thiosemicarbazones

(2015) Patric J. Jansson et al.   PHARMACOLOGICAL RESEARCH

Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6

(2015) Eunyoung Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets

(2015) Wensheng Liu et al.   Oncotarget

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1

(2015) Wensheng Liu et al.   Oncotarget

The Silencing of N-myc Downstream-Regulated Gene-1 in an Orthotopic Pancreatic Cancer Model Leads to More Aggressive Tumor Growth and Metastases

(2014) Corina Kim-Fuchs et al.   DIGESTIVE SURGERY

The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of  -catenin through mechanisms involving FRAT1 and PAK4

(2014) R. Jin et al.   JOURNAL OF CELL SCIENCE

Proteolytic cleavage and truncation of NDRG1 in human prostate cancer cells, but not normal prostate epithelial cells

(2013) Mohammad K. Ghalayini et al.   BIOSCIENCE REPORTS

Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells

(2013) K M Dixon et al.   BRITISH JOURNAL OF CANCER

NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation

(2013) V. Pietiainen et al.   JOURNAL OF CELL SCIENCE

N-myc Downstream Regulated 1 (NDRG1) Is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) during Cellular Stress Caused by Iron Depletion

(2013) Darius J. R. Lane et al.   PLoS One

The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways

(2012) Zaklina Kovacevic et al.   ANTIOXIDANTS & REDOX SIGNALING

N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis

(2012) Wen Liu et al.   EMBO Molecular Medicine

The Iron Chelators Dp44mT and DFO Inhibit TGF-β-induced Epithelial-Mesenchymal Transition via Up-Regulation of N-Myc Downstream-regulated Gene 1 (NDRG1)

(2012) Zhiqiang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo

(2012) David B. Lovejoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

A practical guide to evaluating colocalization in biological microscopy

(2011) Kenneth W. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Novel Thiosemicarbazone Iron Chelators Induce Up-Regulation and Phosphorylation of the Metastasis Suppressor N-myc Down-Stream Regulated Gene 1: A New Strategy for the Treatment of Pancreatic Cancer

(2011) Z. Kovacevic et al.   MOLECULAR PHARMACOLOGY

High- and Low-Affinity Epidermal Growth Factor Receptor-Ligand Interactions Activate Distinct Signaling Pathways

(2011) Jordan A. Krall et al.   PLoS One

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation

(2010) Yuri Frosi et al.   JOURNAL OF CELL BIOLOGY

Breast cancer metastasis driven by ErbB2 and 14-3-3ξ

(2010) Yingqun Wang   Cell Adhesion & Migration

Epidermal growth factor and hepatocyte growth factor cooperate to enhance cell proliferation, scatter, and invasion in murine mammary epithelial cells

(2009) Paolo Accornero et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Iron Chelator-Mediated Alterations in Gene Expression: Identification of Novel Iron-Regulated Molecules That Are Molecular Targets of Hypoxia-Inducible Factor-1  and p53

(2009) F. Saletta et al.   MOLECULAR PHARMACOLOGY

Mechanisms of ErbB receptor negative regulation and relevance in cancer

(2008) William H.D. Fry et al.   EXPERIMENTAL CELL RESEARCH

Endocytosis and intracellular trafficking of ErbBs

(2008) Alexander Sorkin et al.   EXPERIMENTAL CELL RESEARCH

Trafficking of receptor tyrosine kinases to the nucleus

(2008) Graham Carpenter et al.   EXPERIMENTAL CELL RESEARCH

Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line

(2008) Yukio Nishimura et al.   Molecular Cancer