Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA–triggered innate immune responses

Selective Recognition of RNA Substrates by ADAR Deaminase Domains

(2018) Yuru Wang et al.   BIOCHEMISTRY

A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer

(2018) Xinxin Peng et al.   CANCER CELL

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

(2018) Hachung Chung et al.   CELL

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

(2018) Sadeem Ahmad et al.   CELL

Cytochrome P450 research and The Journal of Biological Chemistry

(2018) F. Peter Guengerich   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-associated intronic editing ofHNRPLLgenerates a novel splicing variant linked to cell proliferation

(2018) Yi-Tung Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A-to-I RNA editing — immune protector and transcriptome diversifier

(2018) Eli Eisenberg et al.   NATURE REVIEWS GENETICS

ADARs and editing: The role of A-to-I RNA modification in cancer progression

(2018) Kajsa Fritzell et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ADAR1-mediated regulation of melanoma invasion

(2018) Yael Nemlich et al.   Nature Communications

Adar3 Is Involved in Learning and Memory in Mice

(2018) Dessislava Mladenova et al.   Frontiers in Neuroscience

Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers

(2017) Yumeng Wang et al.   GENOME RESEARCH

ADAR RNA editing in human disease; more to it than meets the I

(2017) Angela Gallo et al.   HUMAN GENETICS

Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma

(2017) Eimile Oakes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors

(2017) Charlotte Lässig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic landscape and regulation of RNA editing in mammals

(2017) Meng How Tan et al.   NATURE

Human cancer tissues exhibit reduced A-to-I editing of miRNAs coupled with elevated editing of their targets

(2017) Yishay Pinto et al.   NUCLEIC ACIDS RESEARCH

RNA editing with CRISPR-Cas13

(2017) David B. T. Cox et al.   SCIENCE

Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma

(2017) Elisa Lazzari et al.   Nature Communications

Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

(2017) Yize Li et al.   eLife

RNA Editing, ADAR1, and the Innate Immune Response

(2017) Qingde Wang et al.   Genes

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis

(2016) Brian J. Liddicoat et al.   EXPERIMENTAL HEMATOLOGY

Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses

(2016) Cyril X. George et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of human RNA editing sites: A historical perspective

(2016) Gokul Ramaswami et al.   METHODS

An efficient system for selectively altering genetic information within mRNAs

(2016) Maria Fernanda Montiel-González et al.   NUCLEIC ACIDS RESEARCH

Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses

(2016) Yize Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADAR1 Suppresses the Activation of Cytosolic RNA-Sensing Signaling Pathways to Protect the Liver from Ischemia/Reperfusion Injury

(2016) Hui Wang et al.   Scientific Reports

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

(2015) Leng Han et al.   CANCER CELL

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

RNA Editing Modulates Human Hepatic Aryl Hydrocarbon Receptor Expression by Creating MicroRNA Recognition Sequence

(2015) Masataka Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measles Virus Defective Interfering RNAs Are Generated Frequently and Early in the Absence of C Protein and Can Be Destabilized by Adenosine Deaminase Acting on RNA-1-Like Hypermutations

(2015) Christian K. Pfaller et al.   JOURNAL OF VIROLOGY

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

STAT2-dependent induction of RNA adenosine deaminase ADAR1 by type I interferon differs between mouse and human cells in the requirement for STAT1

(2015) Cyril X. George et al.   VIROLOGY

Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors

(2015) Nurit Paz-Yaacov et al.   Cell Reports

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

(2015) Debora Fumagalli et al.   Cell Reports

How RIG-I like receptors activate MAVS

(2015) Bin Wu et al.   Current Opinion in Virology

Adenosine Deaminase Acting on RNA 1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs

(2014) Shengyong Yang et al.   JOURNAL OF IMMUNOLOGY

A comprehensive survey of non-canonical splice sites in the human transcriptome

(2014) Guillermo E. Parada et al.   NUCLEIC ACIDS RESEARCH

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

Mammalian conserved ADAR targets comprise only a small fragment of the human editosome

(2014) Yishay Pinto et al.   GENOME BIOLOGY

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

(2013) L. Bazak et al.   GENOME RESEARCH

Measles Virus C Protein Impairs Production of Defective Copyback Double-Stranded Viral RNA and Activation of Protein Kinase R

(2013) C. K. Pfaller et al.   JOURNAL OF VIROLOGY

RADAR: a rigorously annotated database of A-to-I RNA editing

(2013) Gokul Ramaswami et al.   NUCLEIC ACIDS RESEARCH

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

Dynamic Oscillation of Translation and Stress Granule Formation Mark the Cellular Response to Virus Infection

(2012) Alessia Ruggieri et al.   Cell Host & Microbe

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

Protein Kinase PKR Amplification of Interferon β Induction Occurs through Initiation Factor eIF-2α-mediated Translational Control

(2012) Christopher S. McAllister et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine Deaminase Acting on RNA 1 (ADAR1) Suppresses the Induction of Interferon by Measles Virus

(2012) Z. Li et al.   JOURNAL OF VIROLOGY

Stress Granule Formation Induced by Measles Virus Is Protein Kinase PKR Dependent and Impaired by RNA Adenosine Deaminase ADAR1

(2012) K. M. Okonski et al.   JOURNAL OF VIROLOGY

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Accurate identification of human Alu and non-Alu RNA editing sites

(2012) Gokul Ramaswami et al.   NATURE METHODS

Mechanistic insights into editing-site specificity of ADARs

(2012) A. Kuttan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice

(2011) Marion Horsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of RNase L and RNA-dependent Protein Kinase (PKR) by Sunitinib Impairs Antiviral Innate Immunity

(2011) Babal Kant Jha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral

(2011) Charles E. Samuel   VIROLOGY

Predicting sites of ADAR editing in double-stranded RNA

(2011) Julie M. Eggington et al.   Nature Communications

Adenosine Deaminases Acting on RNA, RNA Editing, and Interferon Action

(2010) Cyril X. George et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

(2010) S. V. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Editing independent effects of ADARs on the miRNA/siRNA pathways

(2009) Bret S E Heale et al.   EMBO JOURNAL

RNA-specific Adenosine Deaminase ADAR1 Suppresses Measles Virus-induced Apoptosis and Activation of Protein Kinase PKR

(2009) Ann M. Toth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine Deaminase ADAR1 Increases Gene Expression at the Translational Level by Decreasing Protein Kinase PKR-Dependent eIF-2α Phosphorylation

(2009) Ying Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanisms of Protein Kinase PKR-Mediated Amplification of Beta Interferon Induction by C Protein-Deficient Measles Virus

(2009) C. S. McAllister et al.   JOURNAL OF VIROLOGY

Genome-Wide Identification of Human RNA Editing Sites by Parallel DNA Capturing and Sequencing

(2009) J. B. Li et al.   SCIENCE

RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment

(2009) Zhiqun Li et al.   VIROLOGY

The RNA-activated Protein Kinase Enhances the Induction of Interferon-β and Apoptosis Mediated by Cytoplasmic RNA Sensors

(2008) Christopher S. McAllister et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase PKR Mediates the Apoptosis Induction and Growth Restriction Phenotypes of C Protein-Deficient Measles Virus

(2008) A. M. Toth et al.   JOURNAL OF VIROLOGY

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY

Frequency and fate of microRNA editing in human brain

(2008) Y. Kawahara et al.   NUCLEIC ACIDS RESEARCH

Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5′-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon

(2008) Cyril X. George et al.   VIROLOGY