Review
Pharmacology & Pharmacy
Ekaterina Yu Podyacheva, Ekaterina A. Kushnareva, Andrei A. Karpov, Yana G. Toropova
Summary: Currently, there is an expansion in the pharmacological possibilities of treating cancer, leading to an increase in life expectancy with chemotherapy and supportive treatment. However, complications such as anthracycline-induced cardiomyopathy are a significant concern, requiring further research to understand its development mechanisms through new models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ryota Murata, Hiroshi Watanabe, Hiroto Nosaki, Kento Nishida, Hitoshi Maeda, Motohiro Nishida, Toru Maruyama
Summary: In this study, a long-acting Thioredoxin (Trx) was prepared by fusing human Trx with human serum albumin (HSA) and its efficacy in treating drug-induced heart failure was evaluated. The results showed that HSA-Trx administration suppressed the adverse effects of drug-induced cardiomyopathy, including heart weight decrease, myocardial fibrosis increase, and markers for myocardial damage. HSA-Trx also inhibited oxidative stress and inflammation, as well as the expression of myocardial atrophy factors. The findings suggest that HSA-Trx can improve the pathological condition associated with doxorubicin-induced cardiomyopathy.
Article
Biochemistry & Molecular Biology
Jie A. Wang, Yufeng Tang, Jingjing Zhang, Jie B. Wang, Mengjie Xiao, Guangping Lu, Jiahao Li, Qingbo Liu, Yuanfang Guo, Junlian Gu
Summary: In this study, the researchers investigated the role of the interaction between SIRT1 and SESN2 in DOX-induced cardiomyopathy. They found that SIRT1 deficiency aggravated cardiac damage, while the activation of SIRT1 had protective effects. Further studies revealed that SIRT1 reduced oxidative damage and apoptosis by attenuating the interaction between SESN2 and MDM2, thereby protecting the heart from DOX-induced toxicity.
Article
Pharmacology & Pharmacy
Zirui Zhao, Shilei Yang, Yawen Deng, Liang Wang, Yifen Zhang, Zhenyu Feng, Han Li, Zhongchao Chi, Yunpeng Xie, Deshi Dong
Summary: The study found that Naringin can prevent DOX-related cardiac injury and inhibit oxidative stress, inflammation, and apoptosis in the heart both in vivo and in vitro. These findings suggest that Naringin may serve as a novel approach to prevent cardiac toxicity induced by anthracycline drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abdullah F. AlAsmari, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Mohammed AlSwayyed, Sami I. Alzarea, Ibrahim A. Al-Alallah, Adel Alghamdi, Hassan M. Hakami, Meshal K. Alyousef, Youssef Sari, Nemat Ali
Summary: The study showed that diosmin has a protective effect against doxorubicin-induced hepatotoxicity by restoring hepatic antioxidant factors, reducing inflammatory and apoptotic proteins and genes.
Article
Environmental Sciences
Sara Asaad Abdulkareem Aljumaily, Mehmet Demir, Hulya Elbe, Gurkan Yigitturk, Yasemin Bicer, Eyup Altinoz
Summary: The study aimed to investigate the effects of crocin on doxorubicin-induced cardiotoxicity in rats. Results showed that crocin significantly ameliorated lipid profile, cardiac markers, and oxidative stress indices caused by DOX. Additionally, crocin alleviated histopathological damage in myocardium induced by DOX.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Peipei Zhang, Hao Lu, Yuan Wu, Danbo Lu, Chenguang Li, Xiangdong Yang, Zhangwei Chen, Juying Qian, Junbo Ge
Summary: Doxorubicin (DOX) can lead to mitochondrial dysfunction and heart failure. COX5A, an important regulator of mitochondrial energy metabolism, plays a protective role in DOX-induced cardiomyopathy. The expression of COX5A is decreased in patients with dilated cardiomyopathy and after DOX treatment. Overexpression of COX5A improves cardiac function, glucose uptake, mitochondrial morphology, COX activity, and ATP content in DOX-stimulated mice. COX5A protects against oxidative stress, mitochondrial dysfunction, and cardiomyocyte apoptosis via the PI3K/Akt signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Sotiris Kyriakou, Venetia Tragkola, Michael Plioukas, Ioannis Anestopoulos, Paschalina S. Chatzopoulou, Eirini Sarrou, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis
Summary: The study found that Salvia fruticosa extract SF3 exhibited significant cytotoxic activity against malignant melanoma cells, while showing relative resistance or no cytotoxicity against non-malignant melanoma epidermoid carcinoma and non-tumorigenic melanocyte cells. SF extracts were rich in total phenolic and total flavonoid content with antioxidant capacity, and were able to inhibit melanoma cell growth by inducing both extrinsic and intrinsic apoptotic pathways.
Article
Pharmacology & Pharmacy
Chun Wang, Ling Hu, Shuang Guo, Qing Yao, Xiufen Liu, Bo Zhang, Xiangwen Meng, Xiaosong Yang
Summary: Myocardial apoptosis and necroptosis are key factors in doxorubicin-induced cardiotoxicity, while phosphocreatine (PCr) has been shown to have cardioprotective effects. PCr can alleviate myocardial cell death induced by DOX by increasing antioxidant activity, and activate the TAK1 signaling pathway to promote myocardial survival.
Review
Biochemistry & Molecular Biology
Hiroki Kitakata, Jin Endo, Hidehiko Ikura, Hidenori Moriyama, Kohsuke Shirakawa, Yoshinori Katsumata, Motoaki Sano
Summary: This review discusses the molecular mechanisms of DOX-induced cardiotoxicity, focusing on apoptosis and ferroptosis as the two forms of programmed cell death. Possible therapeutic strategies to prevent DOX cardiotoxicity are also outlined, along with the significance of mitochondrial homeostasis disruption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Yunpeng Zhang, Shuang Liu, Jing Peng, Shifeng Cheng, Qingling Zhang, Nan Zhang, Zandong Zhou, Yue Zhang, Yang Zhao, Tong Liu
Summary: This study evaluated the role of cerium oxide-based nanozymes in preventing and treating doxorubicin-induced cardiotoxicity. The nanoparticles showed excellent antioxidant response and bioregulation, effectively reversing myocardial remodeling and reducing myocardial necrosis. The study suggests that cerium oxide-based nanozymes could be a promising candidate for the prevention and treatment of doxorubicin-induced cardiotoxicity.
Article
Biochemistry & Molecular Biology
Chenfei Li, Zhen Guo, Fangyuan Liu, Peng An, Mingyu Wang, Dan Yang, Qizhu Tang
Summary: Doxorubicin (DOX) is a commonly used chemotherapeutic drug in cancer treatment, but its side effects on the heart restrict its clinical application. In this study, researchers found that apoptosis, oxidative stress, and autophagy all play important roles in DOX-induced cardiac injury. They demonstrated that overexpression of PCSK6, a protein involved in cardiovascular diseases, can protect against DOX-induced cardiac damage by promoting autophagy and inhibiting apoptosis and oxidative stress. They also identified the involvement of SIRT1 and FOXO3a in the protective effect of PCSK6.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Toxicology
Chen Zhang, Qinghua Dan, Song Lai, Yutong Zhang, Erer Gao, Haiyan Luo, Liping Yang, Xiaobo Gao, Cailing Lu
Summary: This study investigated the role of Rab10 in doxorubicin (DOX)-induced cardiotoxicity. The results showed that cardiac-specific overexpression of Rab10 alleviated cardiac dysfunction and mitochondrial damage caused by DOX treatment. Rab10 also inhibited apoptosis and oxidative stress in cardiomyocytes. Furthermore, Rab10 inhibited the cleavage of Mst1, a serine-threonine kinase, mediated by DOX treatment.
TOXICOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Xiaoliang Hu, Cheng Li, Qian Wang, Zhixing Wei, Taizhong Chen, Yuepeng Wang, Yigang Li
Summary: Doxorubicin, a drug with limited clinical application due to its cardiotoxicity, can be alleviated by Dimethyl fumarate (DMF) through reducing oxidative stress and apoptosis via Nrf2 pathway. The study found that DMF significantly improved cell viability and morphology, as well as alleviated DOX-induced cardiac injury, oxidative stress, and apoptosis. Moreover, DMF exerted its protective effects by promoting Nrf2 nuclear translocation and activating downstream antioxidant gene Hmox1. DMF may be a promising candidate to alleviate DOX-related cardiotoxicity in the future.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xuejun Wang, Li Zhang, Mengwen Feng, Zhongqing Xu, Zijie Cheng, Lingmei Qian
Summary: ELA-11 alleviated heart injury induced by DOX and inhibited apoptosis in cardiac tissues by regulating the PI3K/AKT and ERK/MAPK signaling pathways. It also protected cardiomyocytes from oxidative stress-induced apoptosis by interacting with the APJ receptor.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Mejdi Snoussi, Emira Noumi, Hafed Hajlaoui, Lamjed Bouslama, Assia Hamdi, Mohd Saeed, Mousa Alreshidi, Mohd Adnan, Ayshah Al-Rashidi, Kaiss Aouadi, Siwar Ghannay, Ozgur Ceylan, Vincenzo De Feo, Adel Kadri
Summary: This study evaluated the composition and bioactivity of Allium subhirsutum L. extract, demonstrating its potential as a source of bioactive compounds with antioxidant, antimicrobial, antibiofilm, and anti-quorum sensing properties. In vitro and in silico studies revealed the presence of various phytochemicals and identified bioactive compounds. The extract exhibited non-toxicity and showed promising drug ability for further development. These findings support the use of hairy garlic in promoting human health.
Article
Chemistry, Multidisciplinary
Tarun Kumar Dua, Simran Giri, Gouranga Nandi, Ranabir Sahu, Tapan Kumar Shaw, Paramita Paul
Summary: The green synthesis of silver nanoparticles (AgNPs) using an aqueous Eupatorium adenophorum leaf extract as a bioreductant is reported in this article. The E. adenophorum extract not only served as a bioreductant but also acted as a capping agent to stabilize the nanoparticles. Various characterization techniques were adopted to analyze the biosynthesized AgNPs. The AgNPs showed improved antioxidant, antibacterial and photocatalytic activities, suggesting their potential applications in various fields.
Article
Chemistry, Organic
Sovan Dey, Arindam Das, Ram Naresh Yadav, Palash Jyoti Boruah, Prerana Bakli, Tania Baishya, Koushik Sarkar, Anup Barman, Ranabir Sahu, Biplab Maji, Amit Kumar Paul, Md. Firoj Hossain
Summary: A mild and eco-friendly visible-light-induced synthesis of 2-(2-hydrazinyl) thiazole from readily accessible starting materials is reported. The reaction proceeds without the need for a metal catalyst or extrinsic photosensitizer, and only requires visible light and a green solvent. The synthesized compounds showed significant antioxidant and antidiabetic properties in vitro.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Tania Baishya, Priya Das, Gouhar Jahan Ashraf, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Malay Bhattacharya, Ranabir Sahu
Summary: Different parts of Camellia sinensis (L.) were extracted using solvents of varying polarity to examine their phytochemical profiling and biological activities. The highest levels of total phenolic and flavonoid contents were observed in polar solvents, which also showed increased antioxidant, anti-inflammatory, and antidiabetic activities. HPTLC analysis revealed that polar solvents like hydroalcohol, methanol, and water yielded the highest levels of phenolic acids, epigallocatechin gallate, gallocatechin, and theaflavin, particularly in tea leaves. The findings suggested that polar solvents and young tea leaves were beneficial for obtaining extracts and that phenolics exhibited potent antioxidant, anti-inflammatory, and antidiabetic properties.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ankita Mallick, Ranabir Sahu, Gouranga Nandi, Tarun Kumar Dua, Tapan Kumar Shaw, Ankita Dhar, Aditya Kanu, Paramita Paul
Summary: The purpose of this study was to prepare a suitable carrier system to enhance the bioavailability of valacyclovir (VCV) and reduce dose-related side effects for the treatment of herpes. Liposomes encapsulating VCV were synthesized using thin film hydration and reverse-phase evaporation methods. The liposomes showed nanosize range, good colloidal stability, and appreciable drug loading capability. In vitro release studies revealed a biphasic release pattern with initial burst release followed by continuous drug release. The findings suggest that VCV formulated as a liposome can effectively treat herpes with a lower dose and improved bioavailability.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Article
Biochemistry & Molecular Biology
Lucia Caputo, Giuseppe Amato, Laura De Martino, Vincenzo De Feo, Filomena Nazzaro
Summary: Several researchers have studied the health properties of carvacrol and p-cymene, substances found in aromatic plants. In this study, the researchers investigated the potential anti-cholinesterase, anti-alpha-amylase, and neuroprotective effects of these compounds. They found that carvacrol showed inhibitory activities against acetylcholinesterase and butyrylcholinesterase, while also exhibiting anti-alpha-amylase activity. Furthermore, pre-treatment with carvacrol and p-cymene reduced caspase-3 expression in cells under oxidative stress, indicating their potential as neuroprotective agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Bhuvi Sachdeva, Punya Sachdeva, Arvind Negi, Shampa Ghosh, Sungsoo Han, Saikat Dewanjee, Saurabh Kumar Jha, Rakesh Bhaskar, Jitendra Kumar Sinha, Ana Claudia Paiva-Santos, Niraj Kumar Jha, Kavindra Kumar Kesari
Summary: Chitin is a biopolymer derived from marine crustaceans and organisms like bacteria, fungi, and algae, which offers biodegradability and biocompatibility properties suitable for biomedical applications. Its deacetylated derivative, chitosan, also possesses similar properties and can be used as a support material in biomedical applications. Additionally, both chitin and chitosan have intrinsic material properties such as antioxidant, antibacterial, and antitumor activities. This paper focuses on the use of chitin and chitosan biopolymers in drug delivery strategies for cancer treatment.
Article
Plant Sciences
Giuseppe Amato, Lucia Caputo, Rosaria Francolino, Mara Martino, Vincenzo De Feo, Laura De Martino
Summary: Many studies have shown that certain essential oils have herbicidal effects and can be used as alternatives to chemical herbicides. In this study, the chemical composition of essential oils from two ecotypes of O. heracleoticum in Southern Italy was compared and their potential as natural herbicides was investigated using seeds of Raphanus sativus, Sinapis arvensis, and Lolium multiflorum. The study also evaluated the inhibitory activity of the essential oils on the alpha-amylase enzyme, which is involved in seed germination. The results showed that the essential oils exhibited herbicidal and alpha-amylase inhibitory activities, suggesting their potential for further exploration.
Review
Biochemistry & Molecular Biology
Nilanjan Ghosh, Leena Chacko, Hiranmoy Bhattacharya, Jayalakshmi Vallamkondu, Sagnik Nag, Abhijit Dey, Tanushree Karmakar, P. Hemachandra Reddy, Ramesh Kandimalla, Saikat Dewanjee
Summary: Diabetes mellitus (DM) and cardiovascular complications often occur together, creating a challenging situation. The development of diabetic cardiomyopathy (DCM) involves complex pathophysiological pathways at the metabolic and molecular level, leading to structural and functional alterations of the heart. Glucagon-like peptide-1 (GLP-1) analogues and sodium-glucose cotransporter-2 (SGLT-2) inhibitors have shown promising results in improving cardiovascular outcomes in diabetes. This article highlights the pathways contributing to DCM and discusses potential future therapies.
Article
Horticulture
Donato Castronuovo, Vincenzo De Feo, Laura De Martino, Loriana Cardone, Rita Sica, Lucia Caputo, Giuseppe Amato, Vincenzo Candido
Summary: Soil fumigation is an effective method for controlling soilborne pests, but it has limited use due to its non-selectivity and environmental problems. This study evaluates the effects of soil solarization on organic pumpkin yield and antioxidant levels. The results show that solarization increases antioxidant activity and improves yield.
Review
Biochemistry & Molecular Biology
Hafiza Padinharayil, Jinsu Varghese, Mithun Chacko John, Golgodu Krishnamurthy Rajanikant, Cornelia M. Wilson, Minnatallah Al-Yozbaki, Kaviyarasi Renu, Saikat Dewanjee, Rupa Sanyal, Abhijit Dey, Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Alex George
Summary: Continuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) supports therapeutic advances and accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention and management. Global cancer mortality projections indicate that cancer will become the leading cause of death, particularly non-small cell lung cancer (NSCLC) which accounts for a significant portion of lung cancers. Early diagnosis and proper management play crucial roles in NSCLC therapies. Advanced techniques, such as immune checkpoint inhibitors (ICIs) and targeted molecular therapies, have improved the treatment of late-stage NSCLC. However, the improvement of cancer biomarkers and the development of prospective studies are needed for better therapeutic outcomes.
Article
Biochemistry & Molecular Biology
Md. Latifur Rahman, Subhajit Mandal, Priya Das, Gouhar Jahan Ashraf, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Ranabir Sahu
Summary: This study aimed to investigate the effects of different extraction methods on the antioxidant activity and phenolic profiling of black rice. The highest contents of various phenolic compounds and antioxidant activity were observed in microwave-assisted extraction (MAE). MAE also showed the most abundant phenolic compounds. The results suggest that extraction techniques have an impact on the bioactive compounds and their properties.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2023)
Article
Food Science & Technology
Subhajit Mandal, Md. Latifur Rahman, Priya Das, Gouhar Jahan Ashraf, Tarun Kumar Dua, Paramita Paul, Gouranga Nandi, Ranabir Sahu
Summary: This study investigated the effects of maceration, ultrasonic, and microwave-assisted extraction on the phenolic compounds of Tulaipanji rice flour. It was found that microwave-assisted extraction showed the highest phenolic content and antioxidant activity, particularly in bound phenolics.
INTERNATIONAL JOURNAL OF FOOD ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Abhijit Changder, Sanat Kumar Mandal, Saurav Sarkar, Riyasree Paul, Ananya Ghosh, Paramita Paul, Tarun Kumar Dua, Ranabir Sahu, Gouranga Nandi, Lakshmi Kanta Ghosh
Summary: The present study evaluated the application of Cassia fistula seed galactomannan (CFSG) as a tablet binder for diclofenac sodium. The research confirmed the excellent binding capacity of CFSG and its potential as an alternative tablet binder.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Lucia Caputo, Giuseppe Amato, Pietro de Bartolomeis, Laura De Martino, Francesco Manna, Filomena Nazzaro, Vincenzo De Feo, Anna Angela Barba
Summary: Oregano is a versatile herb used for various purposes, and the drying method can significantly affect its essential oil composition and yield. Microwave and shade drying methods achieved the highest oil yield. The choice of drying method is crucial for determining the composition of essential oil.
SCIENTIFIC REPORTS
(2022)
