标题
Current and emerging biologic and small molecule therapies for atopic dermatitis
作者
关键词
-
出版物
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 19, Issue 4, Pages 367-380
出版商
Informa UK Limited
发表日期
2019-01-24
DOI
10.1080/14712598.2019.1573422
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Dupilumab: A Review in Moderate-to-Severe Atopic Dermatitis
- (2018) James E. Frampton et al. AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
- Atopic dermatitis yardstick: Practical recommendations for an evolving therapeutic landscape
- (2018) Mark Boguniewicz et al. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
- Immunologic, microbial, and epithelial interactions in atopic dermatitis
- (2018) Patrick M. Brunner et al. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
- Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement
- (2018) A.M. Drucker et al. BRITISH JOURNAL OF DERMATOLOGY
- Atopic dermatitis in diverse racial and ethnic groups-Variations in epidemiology, genetics, clinical presentation and treatment
- (2018) Bridget P. Kaufman et al. EXPERIMENTAL DERMATOLOGY
- Nemolizumab in patients with moderate-to-severe atopic dermatitis: Randomized, phase II, long-term extension study
- (2018) Kenji Kabashima et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Atopic dermatitis in Chinese patients shows T H 2/T H 17-skewing with psoriasiform features
- (2018) Tom C. Chan et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Serum from Asian patients with atopic dermatitis is characterized by T H 2/T H 22 activation, which is highly correlated with nonlesional skin measures
- (2018) Huei-Chi Wen et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- 453 GBR 830 induces progressive and sustained changes in atopic dermatitis biomarkers in patient skin lesions
- (2018) E. Guttman-Yassky et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- 559 ASN002 a dual oral inhibitor of JAK/SYK signaling improves clinical outcomes and associated cutaneous inflammation in moderate-to-severe atopic dermatitis patients
- (2018) E. Guttman-Yassky et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- IL-17C: A Unique Epithelial Cytokine with Potential for Targeting across the Spectrum of Atopic Dermatitis and Psoriasis
- (2018) Emma Guttman-Yassky et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis
- (2018) Nick Vandeghinste et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Emerging therapies for atopic dermatitis: JAK inhibitors
- (2018) David G. Cotter et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial
- (2018) Emma Guttman-Yassky et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Efficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids: A randomized, placebo-controlled phase II trial (TREBLE)
- (2018) Eric L. Simpson et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis
- (2018) Jason E. Hawkes et al. JOURNAL OF IMMUNOLOGY
- Tradipitant improves worst itch and disease severity in patients with chronic pruritus related to atopic dermatitis
- (2018) JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Risk Factors for Dupilumab-Associated Conjunctivitis in Patients With Atopic Dermatitis
- (2018) Alison D. Treister et al. JAMA Dermatology
- Patch testing of food allergens promotes Th17 and Th2 responses with increased IL-33: a pilot study
- (2017) Benjamin Ungar et al. EXPERIMENTAL DERMATOLOGY
- Systemic immune mechanisms in atopic dermatitis and psoriasis with implications for treatment
- (2017) Emma Guttman-Yassky et al. EXPERIMENTAL DERMATOLOGY
- Anti-IL-33 Antibody Has a Therapeutic Effect in an Atopic Dermatitis Murine Model Induced by 2, 4-Dinitrochlorobenzene
- (2017) Ge Peng et al. INFLAMMATION
- A Phase 1 Study of ANB020, an anti-IL-33 monoclonal Antibody in Healthy Volunteers
- (2017) Marco Londei et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march
- (2017) Tali Czarnowicki et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies
- (2017) Patrick M. Brunner et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- A Treatment Algorithm for Moderate to Severe Atopic Dermatitis in Adults
- (2017) Charles W. Lynde et al. JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
- An Integrated Model of Atopic Dermatitis Biomarkers Highlights the Systemic Nature of the Disease
- (2017) Benjamin Ungar et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13Rα1 and IL-13Rα2
- (2017) B. Popovic et al. JOURNAL OF MOLECULAR BIOLOGY
- Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial
- (2017) Andrew Blauvelt et al. LANCET
- Anti–Interleukin-31 Receptor A Antibody for Atopic Dermatitis
- (2017) Thomas Ruzicka et al. NEW ENGLAND JOURNAL OF MEDICINE
- The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins
- (2017) Patrick M. Brunner et al. Scientific Reports
- The ‘omics’ revolution
- (2016) Margeaux Oliva et al. Current Opinion in Allergy and Clinical Immunology
- Efficacy and safety of ustekinumab treatment in adults with moderate-to-severe atopic dermatitis
- (2016) Saakshi Khattri et al. EXPERIMENTAL DERMATOLOGY
- Efficacy of omalizumab in patients with atopic dermatitis: A systematic review and meta-analysis
- (2016) Hsiao-Han Wang et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Early-onset pediatric atopic dermatitis is T H 2 but also T H 17 polarized in skin
- (2016) Hitokazu Esaki et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation
- (2016) Nan-Lin Wu et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Dupilumab therapy provides clinically meaningful improvement in patient-reported outcomes (PROs): A phase IIb, randomized, placebo-controlled, clinical trial in adult patients with moderate to severe atopic dermatitis (AD)
- (2016) Eric L. Simpson et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial
- (2016) Diamant Thaçi et al. LANCET
- Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
- (2016) Eric L. Simpson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials
- (2016) Nicola A Hanania et al. Lancet Respiratory Medicine
- IL-4 and IL-13 signaling in allergic airway disease
- (2015) Naina Gour et al. CYTOKINE
- Apremilast: A Review in Psoriasis and Psoriatic Arthritis
- (2015) Emma D. Deeks DRUGS
- The translational revolution and use of biologics in patients with inflammatory skin diseases
- (2015) Shinji Noda et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications
- (2015) Mayte Suárez-Fariñas et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization
- (2015) Shinji Noda et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection
- (2015) Hitokazu Esaki et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The immunogenetics of Psoriasis: A comprehensive review
- (2015) Jamie L. Harden et al. JOURNAL OF AUTOIMMUNITY
- Dihomo-γ-linolenic acid prevents the development of atopic dermatitis through prostaglandin D1 production in NC/Tnd mice
- (2015) Yosuke Amagai et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis
- (2014) Jennifer D. Hamilton et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis
- (2014) Yoko Murata et al. JOURNAL OF DERMATOLOGY
- Mechanisms of Oncostatin M-Induced Pulmonary Inflammation and Fibrosis
- (2014) A. Mozaffarian et al. JOURNAL OF IMMUNOLOGY
- IL-17A as an Inducer for Th2 Immune Responses in Murine Atopic Dermatitis Models
- (2014) Saeko Nakajima et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Toxic Interaction between Th2 Cytokines and Staphylococcus aureus in Atopic Dermatitis
- (2014) Jeffrey B. Travers JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Guidelines of care for the management of atopic dermatitis
- (2014) Robert Sidbury et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Guidelines of care for the management of atopic dermatitis
- (2014) Lawrence F. Eichenfield et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Oncostatin M overexpression induces matrix deposition, STAT3 activation and SMAD1 Dysregulation in lungs of fibrosis-resistant BALB/c mice
- (2014) Steven Wong et al. LABORATORY INVESTIGATION
- Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis
- (2014) Lisa A. Beck et al. NEW ENGLAND JOURNAL OF MEDICINE
- IL-33 Promotes the Induction and Maintenance of Th2 Immune Responses by Enhancing the Function of OX40 Ligand
- (2014) Naoko Murakami-Satsutani et al. ALLERGOLOGY INTERNATIONAL
- Periostin in Allergic Inflammation
- (2014) Kenji Izuhara et al. ALLERGOLOGY INTERNATIONAL
- Skin Barrier and Immune Dysregulation in Atopic Dermatitis: An Evolving Story with Important Clinical Implications
- (2014) Tali Czarnowicki et al. Journal of Allergy and Clinical Immunology-In Practice
- Systemic Kappa Opioid Receptor Agonists in the Treatment of Chronic Pruritus: A Literature Review
- (2013) N Phan et al. ACTA DERMATO-VENEREOLOGICA
- Increased efficacy of omalizumab in atopic dermatitis patients with wild-type filaggrin status and higher serum levels of phosphatidylcholines
- (2013) M. Hotze et al. ALLERGY
- Janus kinase inhibitors in autoimmune diseases
- (2013) John J O'Shea et al. ANNALS OF THE RHEUMATIC DISEASES
- New era of biologic therapeutics in atopic dermatitis
- (2013) Emma Guttman-Yassky et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor
- (2013) Franziska Glatzer et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Adult eczema prevalence and associations with asthma and other health and demographic factors: A US population–based study
- (2013) Jonathan I. Silverberg et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Atopic dermatitis: A practice parameter update 2012
- (2013) Lynda Schneider et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis
- (2013) Mayte Suárez-Fariñas et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: A systematic review
- (2013) Evelien Roekevisch et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1
- (2013) Ferda Cevikbas et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The role of IL-22 and Th22 cells in human skin diseases
- (2013) Hideki Fujita JOURNAL OF DERMATOLOGICAL SCIENCE
- Pulmonary Expression of Oncostatin M (OSM) Promotes Inducible BALT Formation Independently of IL-6, Despite a Role for IL-6 in OSM-Driven Pulmonary Inflammation
- (2013) F. M. Botelho et al. JOURNAL OF IMMUNOLOGY
- Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab
- (2013) Mark Ultsch et al. JOURNAL OF MOLECULAR BIOLOGY
- Antibacterial Activity of Long-Chain Polyunsaturated Fatty Acids against Propionibacterium acnes and Staphylococcus aureus
- (2013) Andrew Desbois et al. Marine Drugs
- IL-31 Expression by Inflammatory Cells is Preferentially Elevated in Atopic Dermatitis
- (2012) GFL Hofbauer et al. ACTA DERMATO-VENEREOLOGICA
- The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice
- (2012) Y. Ohsawa et al. ALLERGY
- Mechanistic correlations between two itch biomarkers, cytokine interleukin-31 and neuropeptide β-endorphin, via STAT3/calcium axis in atopic dermatitis
- (2012) C.-H. Lee et al. BRITISH JOURNAL OF DERMATOLOGY
- A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma
- (2012) Edward Piper et al. EUROPEAN RESPIRATORY JOURNAL
- Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis
- (2012) Julia K. Gittler et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- IL-33 and ST2 in Atopic Dermatitis: Expression Profiles and Modulation by Triggering Factors
- (2012) Terhi Savinko et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Reporting, Representation, and Subgroup Analysis of Race and Ethnicity in Published Clinical Trials of Atopic Dermatitis in the United States Between 2000 and 2009
- (2012) Stefanie A. Hirano et al. PEDIATRIC DERMATOLOGY
- Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes
- (2011) D. Gutowska-Owsiak et al. BRITISH JOURNAL OF DERMATOLOGY
- IgE, Mast Cells, and Eosinophils in Atopic Dermatitis
- (2011) Fu-Tong Liu et al. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- Signaling by IL-31 and functional consequences
- (2011) Christian Cornelissen et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Contrasting pathogenesis of atopic dermatitis and psoriasis—Part II: Immune cell subsets and therapeutic concepts
- (2011) Emma Guttman-Yassky et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Lesional dendritic cells in patients with chronic atopic dermatitis and psoriasis exhibit parallel ability to activate T-cell subsets
- (2011) Hideki Fujita et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Contrasting pathogenesis of atopic dermatitis and psoriasis—Part I: Clinical and pathologic concepts
- (2011) Emma Guttman-Yassky et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- IL-31 regulates differentiation and filaggrin expression in human organotypic skin models
- (2011) Christian Cornelissen et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Role of IL-33 in inflammation and disease
- (2011) Ashley M Miller Journal of Inflammation-London
- The Role of TSLP in IL-13-Induced Atopic March
- (2011) Zhou Zhu et al. Scientific Reports
- Signal transduction pathways and transcriptional regulation in Th17 cell differentiation
- (2010) Kiyoshi Hirahara et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Activation of human eosinophils and epidermal keratinocytes by Th2 cytokine IL-31: implication for the immunopathogenesis of atopic dermatitis
- (2010) P. F.-Y. Cheung et al. INTERNATIONAL IMMUNOLOGY
- Staphylococcal exotoxins are strong inducers of IL-22: A potential role in atopic dermatitis
- (2010) Margarete Niebuhr et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- A Mouse Model of Airway Disease: Oncostatin M-Induced Pulmonary Eosinophilia, Goblet Cell Hyperplasia, and Airway Hyperresponsiveness Are STAT6 Dependent, and Interstitial Pulmonary Fibrosis Is STAT6 Independent
- (2010) D. K. Fritz et al. JOURNAL OF IMMUNOLOGY
- IL-23-Mediated Psoriasis-Like Epidermal Hyperplasia Is Dependent on IL-17A
- (2010) H. L. Rizzo et al. JOURNAL OF IMMUNOLOGY
- The Role of the Transcription Factor CREB in Immune Function
- (2010) A. Y. Wen et al. JOURNAL OF IMMUNOLOGY
- Prevalence of Atopic Dermatitis among Korean Adults Visiting Health Service Center of the Catholic Medical Center in Seoul Metropolitan Area, Korea
- (2010) Min Joo Kim et al. JOURNAL OF KOREAN MEDICAL SCIENCE
- Antipruritic treatment with systemic μ-opioid receptor antagonists: A review
- (2010) Ngoc Quan Phan et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
- (2009) Peter M Elias et al. Current Opinion in Allergy and Clinical Immunology
- Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: Regulation of the type-II IL-4 receptor chains IL-4Rα and IL-13Rα1
- (2009) Dominik K. Fritz et al. EXPERIMENTAL CELL RESEARCH
- Janus kinases in immune cell signaling
- (2009) Kamran Ghoreschi et al. IMMUNOLOGICAL REVIEWS
- Cytokine modulation of atopic dermatitis filaggrin skin expression
- (2009) Michael D. Howell et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells
- (2009) Kristine E. Nograles et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The histamine H4 receptor is functionally expressed on TH2 cells
- (2009) Ralf Gutzmer et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells
- (2009) Sara Trifari et al. NATURE IMMUNOLOGY
- Fatty acid composition abnormalities in atopic disease: evidence explored and role in the disease process examined
- (2008) A. Sala-Vila et al. CLINICAL AND EXPERIMENTAL ALLERGY
- Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
- (2008) Byung Eui Kim et al. CLINICAL IMMUNOLOGY
- Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC/Nga mice: a model of atopic dermatitis
- (2008) Øystein Grimstad et al. EXPERIMENTAL DERMATOLOGY
- Basis for the barrier abnormality in atopic dermatitis: Outside-inside-outside pathogenic mechanisms
- (2008) Peter M. Elias et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- A novel IL-1 family cytokine, IL-33, potently activates human eosinophils
- (2008) W. Brett Cherry et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Possible Pathogenic Role of Th17 Cells for Atopic Dermatitis
- (2008) Chizuko Koga et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Transgenic Expression of Interleukin-13 in the Skin Induces a Pruritic Dermatitis and Skin Remodeling
- (2008) Tao Zheng et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Effects of Atypical -Opioid Receptor Agonists on Intrathecal Morphine-Induced Itch and Analgesia in Primates
- (2008) M.-C. Ko et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
- (2008) Kim A Papp et al. LANCET
- Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses
- (2008) C Blanchard et al. Mucosal Immunology
- Atopic Dermatitis
- (2008) Thomas Bieber NEW ENGLAND JOURNAL OF MEDICINE
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