Article
Medicine, General & Internal
Ioana Corina Bocsan, Ioana Adriana Muntean, Nicolae Miron, Irena Pintea, Carmen Teodora Dobrican, Corina Ureche, Anca Dana Buzoianu, Diana Deleanu
Summary: Soluble ICAM-1 and VCAM-1 play important roles in allergic rhinitis (AR), and H1 antihistamines can improve AR symptoms and reduce the levels of adhesion molecules. This study found that patients with grass pollen-induced AR had higher levels of ICAM-1 and VCAM-1 compared to healthy controls during pollen exposure. Despite antihistaminic therapy, these levels tended to remain high during pollen season.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dermatology
Audrey Progneaux, Celine Evrard, Valerie De Glas, Alix Fontaine, Celine Dotreppe, Evelyne De Vuyst, Arjen F. Nikkels, Vicente Garcia-Gonzalez, Laure Dumoutier, Catherine Lambert de Rouvroit, Yves Poumay
Summary: Atopic dermatitis (AD) is an inflammatory disease characterized by an alteration of epidermal barrier due to the release of IL-4 and IL-13. IL-2R gamma, a cytokine receptor subunit, is induced in keratinocytes and contributes to the alteration of the epidermal barrier and regulation of IL-13R alpha 2 expression. The expression of IL-2R gamma is observed in keratinocytes of AD lesional skin, suggesting its role in the disease.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Agronomy
Tingzhen Wang, Mingjia Liu, Yufeng Tian, Yingyan Han, Chaojie Liu, Jinghong Hao, Shuangxi Fan
Summary: This study investigates the important role of mitogen-activated protein kinase 6 (MAPK6) in high temperature bolting of lettuce. The researchers amplified the full-length coding sequence of the LsMAPK6 gene and analyzed its expression using real-time polymerase chain reaction. The results demonstrate that LsMAPK6 is mainly expressed in the stem, stem apex, and taproot, and its expression is significantly promoted by high temperatures.
Review
Gastroenterology & Hepatology
Benno Traub, Aileen Roth, Marko Kornmann, Uwe Knippschild, Joachim Bischof
Summary: Pancreatic cancer is a devastating disease with poor survival rates, prompting the need for new therapeutic approaches. Protein kinases play crucial roles in development and pathogenesis, making them potential targets for precision medicine in patients with deregulated kinase pathways.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Plant Sciences
Xi Zhu, Ning Zhang, Xue Liu, Shigui Li, Jiangwei Yang, Xusheng Hong, Fangfang Wang, Huaijun Si
Summary: The study demonstrates that overexpression of StMAPK11 can promote potato growth, physiological activities, and photosynthesis under drought conditions, indicating its crucial role in enhancing potato drought resistance. The up-regulation of StMAPK11 intensifies drought resistance by elevating antioxidant activities and photosynthesis, providing new insights into its function in drought response.
PLANT CELL REPORTS
(2021)
Review
Pharmacology & Pharmacy
Nathalia Grave, Thamiris Becker Scheffel, Fernanda Fernandes Cruz, Liliana Rockenbach, Marcia Ines Goettert, Stefan Laufer, Fernanda Bueno Morrone
Summary: Gliomas are debilitating malignant brain tumors with limited response to therapies, driven by molecular abnormalities like mutations in regulatory networks. The MAPK pathway, particularly p38 MAPK activation, plays a crucial role in glioma cell invasion and metastasis, and is associated with tumor grade and chemotherapy resistance, underlining its potential as a therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tadej Petreski, Nejc Piko, Robert Ekart, Radovan Hojs, Sebastjan Bevc
Summary: Chronic kidney disease is a major health problem in modern society, with a continuously rising prevalence. Recent studies have identified novel markers and gained new insights into the pathogenesis of CKD. Further large-scale studies are needed to establish the role of these markers in clinical practice.
Article
Microbiology
Wuyun Lv, Yu Xiao, Zhe Xu, Hong Jiang, Qi Tong, Zhengyi Wang
Summary: The role of paxillin in signal pathways in phytopathogenic fungi is not well understood. This study reveals that MoPax1 activates MAP kinase signaling pathways and autophagy through its interaction with MoMka1, and plays an important role in appressorium-mediated plant infection by the rice blast fungus.
Article
Food Science & Technology
Jeong-Won Kim, Jin-Hwa Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Oh Lim, Jong-Choon Kim, Je-Won Ko, Tae-Won Kim
Summary: In this study, the protective effects of DADS against 1,3-DCP-induced hepatotoxicity and oxidative damage were investigated. The results showed that DADS treatment inhibited the increase in serum aminotransferase levels and reduced histopathological alterations in the liver induced by 1,3-DCP. Additionally, DADS treatment reduced 1,3-DCP-induced apoptotic changes in the liver and inhibited phosphorylation of MAPKs. These protective effects may be related to the inhibition of CYP2E1 expression, enhancement of antioxidant enzyme activity, and reduction of apoptotic activity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Oncology
Lih Y. Tan, Michaelia P. Cockshell, Eli Moore, Kay K. Myo Min, Michael Ortiz, M. Zahied Johan, Brenton Ebert, Andrew Ruszkiewicz, Michael P. Brown, Lisa M. Ebert, Claudine S. Bonder
Summary: This study reveals that melanoma cells with vasculogenic mimicry (VM) ability can actively recruit leukocytes to promote cancer cell survival. Analysis of patient samples confirms the presence of this mechanism in actual organisms.
Article
Pharmacology & Pharmacy
Chaojun Kong, Longfei Jia, Jianping Jia
Summary: This study demonstrated that gamma-mangostin can attenuate oxidative stress and inflammation caused by Aβ42 oligomers, while protecting neurons from toxic medium-induced injury, suggesting its potential protective effect in Alzheimer's disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Allergy
Qingxiang Zeng, Yinhui Zeng, Yiquan Tang, Wenlong Liu, Changzhi Sun
Summary: IL-35 plays inhibitive roles in apoptosis, adhesion, migration, and activation of eosinophils in allergic rhinitis.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Biology
Theresa Rauschendorfer, Selina Gurri, Irina Heggli, Luigi Maddaluno, Michael Meyer, Alvaro Ingles-Prieto, Harald Janovjak, Sabine Werner
Summary: FGFs and their receptors FGFRs are crucial in cell signaling, and the light-activated FGFR2 variant OptoR2 shows cell type-specific limitations in long-term in vitro and in vivo settings. The complex consequences highlight the need to consider relevant cellular contexts when transferring optogenetic cell signaling tools.
LIFE SCIENCE ALLIANCE
(2021)
Review
Cell Biology
Meng Feng, Shuping Zhou, Yong Yu, Qinghong Su, Xiaofan Li, Wei Lin
Summary: Dendritic cells (DCs) are a class of antigen-presenting cells with crucial roles in immune activation and tolerance. Understanding the migration mechanisms and regulatory factors of different DC subgroups provides new insights for disease treatment, such as infection, tumors, and vaccine preparation. Various factors, including chemokines, membrane molecules, and microenvironments, influence DC migration and immunological functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Irina A. Khvorova, Olga Nadei, Natalia Agalakova
Summary: The study found high expression of ERK1/2 and JNK in river lamprey erythrocytes and liver tissues, with only trace amounts of p38. ERK1/2 and JNK were identified as both cytosolic and membrane enzymes, while p38 was mainly cytosolic. During pre-spawning starvation, the total cellular amounts of ERK1/2 and phospho-ERK1/2 remained relatively stable.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Dermatology
Kam Lun Hon, Margaret Ip, Chun Kwok Wong, Ben Chung Lap Chan, Ping Chung Leung, Ting Fan Leung
JOURNAL OF DERMATOLOGICAL TREATMENT
(2018)
Article
Rheumatology
Jiayun Shen, Steven H. Lam, Qing Shang, Chun-Kwok Wong, Edmund K. Li, Priscilla Wong, Emily W. Kun, Isaac T. Cheng, Martin Li, Tena K. Li, Tracy Y. Zhu, Jack Jock-Wai Lee, Mimi Chang, Alex Pui-Wai Lee, Lai-Shan Tam
JOURNAL OF RHEUMATOLOGY
(2018)
Article
Rheumatology
Ngar-Woon Kam, Dehua Liu, Zhe Cai, Wah-Yan Mak, Chun-Kwok Wong, Kwok-Hing Chiu, Kam-Yiu Wong, Wai-Leuk Tsang, Lai-Shan Tam
JOURNAL OF RHEUMATOLOGY
(2018)
Article
Integrative & Complementary Medicine
Tianbo Zhang, Mengjie Xiao, Chun-Kwok Wong, Ka-Pun Chris Mok, Xin Zhao, Huihui Ti, Pang-Chui Shaw
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Article
Multidisciplinary Sciences
Dehua Liu, Ben Chung-Lap Chan, Ling Cheng, Miranda Sin-Man Tsang, Jing Zhu, Chun-Wai Wong, Delong Jiao, Helen Yau-Tsz Chan, Ping Chung Leung, Christopher Wai-Kei Lam, Chun Kwok Wong
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Jing Zhu, Jie Dong, Lu Ji, Peiyong Jiang, Ting Fan Leung, Dehua Liu, Lai Guan Ng, Miranda Sin-Man Tsang, Delong Jiao, Christopher Wai-Kei Lam, Chun-Kwok Wong
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Miranda Sin-Man Tsang, Sau-Wan Cheng, Jing Zhu, Karam Atli, Ben Chung-Lap Chan, Dehua Liu, Helen Yau-Tsz Chan, Xiaoyu Sun, Ida Miu-Ting Chu, Kam-Lun Hon, Christopher Wai-Kei Lam, Pang-Chui Shaw, Ping-Chung Leung, Chun-Kwok Wong
Article
Clinical Neurology
Wentao Li, Carol Chi-Hei Kwok, Dominic Chun-Wan Chan, Amy Wing-Yin Ho, Chung-Shun Ho, Jihui Zhang, Yun Kwok Wing, Feng Wang, Lap Ah Tse
Article
Pharmacology & Pharmacy
Xiao-Xiao Wu, Grace Gar-Lee Yue, Jin-Run Dong, Christopher Wai-Kei Lam, Chun-Kwok Wong, Ming-Hua Qiu, Clara Bik-San Lau
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Miranda Sin-Man Tsang, Pang-Chui Shaw, Ida Miu-Ting Chu, Ling Cheng, Eric Chun-Wai Wong, David Tai-Wai Lau, Christopher Wai-Kei Lam, Chun-Kwok Wong
Article
Biology
Forrest Tin Wai Cheung, Amy Wing Yin Ho, Joey Wing Yan Chan, Xiao Li, Ngan Yin Chan, Jihui Zhang, Chung Shun Ho, Yun Kwok Wing, Shirley Xin Li
Summary: The study aimed to validate the Chinese version of the Munich Chronotype Questionnaire (MCTQ) in Chinese youth and explore its utility in individuals with insomnia. The results showed significant correlations between MCTQ parameters and circadian preference and insomnia symptoms. MCTQ was found to have good reliability and validity in Chinese youth and could be useful in assessing chronotype in individuals with insomnia.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Meeting Abstract
Immunology
C. -K. Wong, T. -H. Hou, K. -L. Hon, J. Zhu, C. W. -K. Lam
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Immunology
M. S. M. Tsang, C. K. Wong
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Review
Immunology
Ben C. L. Chan, Christopher W. K. Lam, Lai-Shan Tam, Chun K. Wong
FRONTIERS IN IMMUNOLOGY
(2019)
Meeting Abstract
Rheumatology
S. L. Yu, Y. B. Huo, C. H. Huang, Y. Tao, W. H. Huang, C. K. Wong, L. S. Tam, H. N. Qiu, R. L. Chen, C. H. Huang, L. Zhong
ANNALS OF THE RHEUMATIC DISEASES
(2018)