Review
Cell Biology
Joseena Iype, Michaela Fux
Summary: This study focuses on the role of eosinophils and basophils in allergic diseases, suggesting their potential interaction and influence on each other in allergic inflammations.
Article
Immunology
Bo Peng, Lin Sun, Meng Zhang, Huacheng Yan, Guochao Shi, Zhenwei Xia, Ranran Dai, Wei Tang
Summary: IL-25 plays a significant role in enhancing antigen uptake by eosinophils and increasing the expression of co-stimulator molecules, thus inducing Th2 priming in the context of allergic inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Zhao, Bin Wang, Lili Zhang, Hong Jin
Summary: This study evaluated the effect of eosinophil infiltration in the esophageal muscularis propria on esophageal motility in mice. The results showed that long-term exposure to OVA could induce eosinophil infiltration, leading to esophageal motility disorders and histopathological features similar to a subgroup of AC patients.
Article
Biotechnology & Applied Microbiology
Pei-Chuan Chiang, Jeng-Chang Chen, Li-Chen Chen, Ming-Ling Kuo
Summary: High levels of allergen exposure can increase the prevalence of asthma in developed countries. Traditional treatments for asthma cannot fully control the disease, so the development of novel approaches is still important. Based on the balance between Th1 and Th2 immune responses, enhancing Th1 response has the potential to alleviate Th2 response. In this study, researchers overexpressed single chain IL-12 through a viral vector and observed its efficacy in a mouse model of asthma. The results showed that the overexpression of IL-12 significantly suppressed cell infiltration, mucus secretion, and reduced specific IgE levels. It also modulated the expression of relevant genes.
HUMAN GENE THERAPY
(2022)
Article
Cell Biology
Xu Bai, Hui Chen, Brian G. Oliver
Summary: In this study, POSTN was identified as a promising biomarker for predicting the prognosis of lung cancer patients. Upregulated POSTN was found to be associated with immune cell infiltration, particularly in lung squamous cell carcinoma (LUSC). Downregulation of specific miRNAs targeted by POSTN, such as has-miR-144-3p and has-miR-30e-3p, was also linked to poor prognosis in LUSC patients.
Article
Environmental Sciences
Joyceline De Volder, Annelies Bontinck, Katrien De Grove, Iris Dirven, Valerie Haelterman, Guy Joos, Guy Brusselle, Tania Maes
Summary: Experimental studies suggest that neutrophils could contribute to allergic asthma pathogenesis, that is mainly driven by type 2 immunity. Inhalation of diesel exhaust particles (DEP) is implicated in both exacerbation and development of asthma. Since exposure to DEP is associated with a neutrophilic component, we aimed to investigate how exposure to the combination of allergens and DEP modulates neutrophilic responses.
ENVIRONMENTAL POLLUTION
(2023)
Article
Allergy
William E. LeSuer, Melanie Kienzl, Sergei I. Ochkur, Rudolf Schicho, Alfred D. Doyle, Benjamin L. Wright, Matthew A. Rank, Alexander S. Krupnick, Hirohito Kita, Elizabeth A. Jacobsen
Summary: This study demonstrates the reciprocal role of eosinophils in the activation of ILC2s in allergic asthma and in vitro models. Eosinophils release mediators that promote ILC2 proliferation and chemotaxis, while ILC2s also have feedback effects on eosinophils.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nuno Carvalho, Elisabete Carolino, Helder Coelho, Ana Lucia Barreira, Luisa Moreira, Margarida Andre, Susana Henriques, Carlos Cardoso, Luis Moita, Paulo Matos Costa
Summary: The study aims to evaluate the involvement of eosinophil granule proteins in acute appendicitis and assess the diagnostic accuracy of these proteins in detecting and distinguishing between complicated and uncomplicated acute appendicitis. The study found that the concentrations of eosinophil granule proteins were significantly higher in the appendicular lavage fluid and serum of patients with acute appendicitis, indicating a potential role of an allergic reaction in the pathogenesis of acute appendicitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Hyung-Geun Moon, Seung-jae Kim, Ki-Hyun Kim, Young-Mee Kim, Jalees Rehman, Hyun Lee, Yi-Chien Wu, Steve Seung-Young Lee, John W. Christman, Steven J. Ackerman, Minhyung Kim, Sungyoung You, Gye Young Park
Summary: This study aims to investigate the cellular mechanism of tissue-resident macrophages involved in the resolution process of eosinophilic lung inflammation. Using mass cytometry, single-cell RNA sequencing, and biophysical and immunological analyses, it was found that the CCL26-CX3CR1 pathway plays a crucial role in resolving eosinophilic allergic lung inflammation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Plant Sciences
Sung Bae Kim, Yun-Soo Seo, Hyo Seon Kim, A. Yeong Lee, Jin Mi Chun, Wook Jin Kim, Byeong Cheol Moon, Bo-In Kwon
Summary: The study found that the root extract of Angelica reflexa B.Y.Lee (AR) has anti-asthmatic effects by reducing inflammation and symptoms of asthma, as well as regulating the activation level of Th2 cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Benjamin J. Ulrich, Rakshin Kharwadkar, Michelle Chu, Abigail Pajulas, Charanya Muralidharan, Byunghee Koh, Yongyao Fu, Hongyu Gao, Tristan A. Hayes, Hong-Ming Zhou, Nick P. Goplen, Andrew S. Nelson, Yunlong Liu, Amelia K. Linnemann, Matthew J. Turner, Paula Licona-Limon, Richard A. Flavell, Jie Sun, Mark H. Kaplan
Summary: In this study, a specific subpopulation of CD4(+) T cells that secrete IL-9 was identified in a mouse model of chronic allergen exposure. These IL-9-secreting cells have a resident memory T cell phenotype and play a crucial role in the allergic recall response, as blocking or deleting IL-9 significantly reduced airway inflammation and hyperreactivity.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
Jutamas Suwanpradid, Min Jin Lee, Peter Hoang, Jeffery Kwock, Lauren P. Floyd, Jeffrey S. Smith, Zhinan Yin, Amber R. Atwater, Sudarshan Rajagopal, Ross M. Kedl, David L. Corcoran, Jennifer Y. Zhang, Amanda S. MacLeod
Summary: The crosstalk between T cells, dendritic cells, and macrophages in leukocyte clusters within barrier tissues provides a new concept for T cell activation in the skin. It was found that macrophages produce IL-27 which induces IL-15 production from other cells within leukocyte clusters, enhancing the survival of skin T cells. Blocking the IL-27 pathway in CHS mice led to decreased expression of the T cell survival gene BCL2, resulting in a decline in dermal CD8(+) T cells and T cell cluster numbers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jyun-Yi Du, Hong-Yue Lai, Yu-Wei Hsiao, Jhih-Ying Chi, Ju-Ming Wang
Summary: This study reveals the role of Pentraxin 3 (PTX3) in shrimp allergy and demonstrates that PTX3 can facilitate mast cell activation and immune inflammatory responses. The findings also suggest that RI37 can serve as a therapeutic agent for shrimp allergy.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jian-Bo Shao, Xiang-Qian Luo, Li-Hua Mo, Gui Yang, Zhi-Qiang Liu, Jiang-Qi Liu, Zhi-Gang Liu, Da-Bo Liu, Ping-Chang Yang
Summary: In this study, high Ras activation was detected in eosinophils isolated from nasal mucosal tissues of allergic rhinitis patients, associated with apoptosis resistance. The expression of Twist protein in allergic rhinitis eosinophils was positively correlated with Ras activation. Sensitization to IgG induced Twist expression and conferred eosinophils apoptosis resistance through Ras activation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Immunology
Fangzhou Teng, Weifeng Tang, Tulake Wuniqiemu, Jingjing Qin, Yaolong Zhou, Xi Huang, Shiyuan Wang, Xueyi Zhu, Zhao Tang, La Yi, Ying Wei, Jingcheng Dong
Summary: This study identified hypermethylated and hypomethylated m6A peaks in lung tissues of asthmatic mice, suggesting a role for m6A methylation in the pathogenesis of asthma, particularly in immune function and regulation. The differential methylated mRNAs were found to be involved in various immune function-relevant signaling pathways. Explored RNA-binding proteins recognizing these differentially methylated peak sites mostly relate to mRNA biogenesis and metabolism, highlighting the potential mechanisms underlying the m6A-mediated regulation in asthma.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tariq R. Altamimi, Qutuba G. Karwi, Golam Mezbah Uddin, Arata Fukushima, Jennifer Q. Kwong, Jeffery D. Molkentin, Gary D. Lopaschuk
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Multidisciplinary Sciences
Jason Karch, Michael J. Bround, Hadi Khalil, Michelle A. Sargent, Nadina Latchman, Naohiro Terada, Pablo M. Peixoto, Jeffery D. Molkentin
Article
Multidisciplinary Sciences
Ronald J. Vagnozzi, Marjorie Maillet, Michelle A. Sargent, Hadi Khalil, Anne Katrine Z. Johansen, Jennifer A. Schwanekamp, Allen J. York, Vincent Huang, Matthias Nahrendorf, Sakthivel Sadayappan, Jeffery D. Molkentin
Article
Cardiac & Cardiovascular Systems
Georgios Amanakis, Junhui Sun, Maria M. Fergusson, Shane McGinty, Chengyu Liu, Jeffery D. Molkentin, Elizabeth Murphy
Summary: The study demonstrates that C202 plays a crucial role in the binding of CypD to PTP, with its oxidation state potentially regulating the opening of mitochondrial permeability transition pore. Mutating C202 reduces ischemia/reperfusion injury, and C202 is found to be S-nitrosylated during ischemic preconditioning.
CARDIOVASCULAR RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Salvatore Antonucci, Moises Di Sante, Justina Sileikyte, Jordan Deveraux, Tyler Bauer, Michael J. Bround, Roberta Menabo, Melanie Paillard, Petra Alanova, Michela Carraro, Michel Ovize, Jeffery D. Molkentin, Michael Cohen, Michael A. Forte, Paolo Bernardi, Fabio Di Lisa, Elizabeth Murphy
PHARMACOLOGICAL RESEARCH
(2020)
Article
Medicine, General & Internal
Ana Helena M. Pereira, Alisson C. Cardoso, Silvio R. Consonni, Renata R. Oliveira, Angela Saito, Maria Luisa B. Vaggione, Jose R. Matos-Souza, Marcelo F. Carazzolle, Anderson Goncalves, Juliano L. Fernandes, Gustavo C. A. Ribeiro, Mauricio M. Lopes, Jeffery D. Molkentin, Kleber G. Franchini
Letter
Cardiac & Cardiovascular Systems
Ronald J. Vagnozzi, Michelle A. Sargent, Jeffery D. Molkentin
Article
Cardiac & Cardiovascular Systems
Shan Lu, Zhandi Liao, Xiyuan Lu, Doerthe M. Katschinski, Mark Mercola, Ju Chen, Joan Heller Brown, Jeffery D. Molkentin, Julie Bossuyt, Donald M. Bers
CIRCULATION RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Jiuzhou Huo, Shan Lu, Jennifer Q. Kwong, Michael J. Bround, Kelly M. Grimes, Michelle A. Sargent, Milton E. Brown, Michael E. Davis, Donald M. Bers, Jeffery D. Molkentin
CIRCULATION RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Michael J. Bround, Donald M. Bers, Jeffery D. Molkentin
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2020)
Article
Medicine, Research & Experimental
Sonja C. Schriever, Dhiraj G. Kabra, Katrin Pfuhlmann, Peter Baumann, Emily Baumgart, Joachim Nagler, Fabian Seebacher, Luke Harrison, Martin Irmler, Stephanie Kullmann, Felipe Correa-da-Silva, Florian Giesert, Ruchi Jain, Hannah Schug, Julien Castel, Sarah Martinez, Moya Wu, Hans-Ulrich Haering, Martin Hrabe de Angelis, Johannes Beckers, Timo D. Mueller, Kerstin Stemmer, Wolfgang Wurst, Jan Rozman, Ruben Nogueiras, Meri De Angelis, Jeffery D. Molkentin, Natalie Krahmer, Chun-Xia Yi, Mathias Schmidt, Serge Luquet, Martin Heni, Matthias H. Tschoep, Paul T. Pfluger
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Luis Hortells, Inigo Valiente-Alandi, Zachary M. Thomas, Emma J. Agnew, Dan J. Schnell, Allen J. York, Ronald J. Vagnozzi, Evan C. Meyer, Jeffery D. Molkentin, Katherine E. Yutzey
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Tobias Weinberger, Dena Esfandyari, Denise Messerer, Gulce Percin, Christian Schleifer, Raffael Thaler, Lulu Liu, Christopher Stremmel, Vanessa Schneider, Ronald J. Vagnozzi, Jennifer Schwanenkamp, Maximilian Fischer, Katrin Busch, Kay Klapproth, Hellen Ishikawa-Ankerhold, Lukas Kloesges, Anna Titova, Jeffery D. Molkentin, Yasuhiro Kobayashi, Stefan Engelhardt, Steffen Massberg, Claudia Waskow, Elisa Gomez Perdiguero, Christian Schulz
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Sonia R. Singh, Moritz Meyer-Jens, Erda Alizoti, W. Clark Bacon, Gregory Davis, Hanna Osinska, James Gulick, Silke Reischmann-Duesener, Ellen Orthey, Patrick M. McLendon, Jeffery D. Molkentin, Saskia Schlossarek, Jeffrey Robbins, Lucie Carrier
Summary: The study revealed that ZNF418 activates the ALP, inhibits the UPS, and regulates genes associated with cardiomyocyte structure and function. RNA-seq analysis showed that ZNF418 also plays a role in regulating genes involved in cardiac development and/or hypertrophy.
Article
Cardiac & Cardiovascular Systems
Talya Razin, Naomi Melamed-Book, Jasmin Argaman, Iris Galin, Yosef Lowy, Eli Anuka, Nili Naftali-Shani, Michal Kandel-Kfir, Benjamin P. Garfinkel, Shlomi Brielle, Zvi Granot, Ron N. Apte, Simon J. Conway, Jeffery D. Molkentin, Yehuda Kamari, Jonathan Leor, Joseph Orly
Summary: This study highlights the overlooked cellular responses evolved under stress conditions associated with the default inflammatory response to MI. The observations suggest that LV IL-1 alpha is cardioprotective through induction of StAR expression in border zone fibroblasts, rendering them resistant to apoptosis. This acquired survival feature has long-term ramifications on heart recovery post-MI by diminishing adverse remodeling and improving heart function.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)