Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

(2018) Karen Frudd et al.   Nature Communications

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

(2018) Bernadette Carroll et al.   Nature Communications

Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip

(2017) Alise J. Ponsero et al.   MOLECULAR CELL

C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

(2017) Ilija Melentijevic et al.   NATURE

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans

(2017) Caroline Kumsta et al.   Nature Communications

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

(2017) Jessica T Chang et al.   eLife

Non-linear impact of glutathione depletion on C. elegans life span and stress resistance

(2017) Nadine Urban et al.   Redox Biology

Caenorhabditis elegans as a model for understanding ROS function in physiology and disease

(2017) Antonio Miranda-Vizuete et al.   Redox Biology

Control of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestrated

(2016) Beatriz Sáenz-Narciso et al.   BIOESSAYS

Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development

(2016) José Antonio Mora-Lorca et al.   FREE RADICAL BIOLOGY AND MEDICINE

Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications

(2016) Xin Gen Lei et al.   PHYSIOLOGICAL REVIEWS

Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors

(2016) Sunhyo Kim et al.   Scientific Reports

The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions

(2016) Liying Guan et al.   PLoS Genetics

Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model

(2016) Sheng Fong et al.   Scientific Reports

KEAP1–NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity

(2015) Matthew Dodson et al.   BIOCHEMICAL JOURNAL

Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments

(2015) J. Kirstein et al.   EMBO JOURNAL

Proteinopathies, a core concept for understanding and ultimately treating degenerative disorders?

(2015) Thomas A. Bayer   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Redox regulation of Rac1 by thiol oxidation

(2015) G. Aaron Hobbs et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The cysteine proteome

(2015) Young-Mi Go et al.   FREE RADICAL BIOLOGY AND MEDICINE

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

(2015) Sofi Eriksson et al.   Nature Communications

Microtubule-Mediated Inositol Lipid Signaling Plays Critical Roles in Regulation of Blebbing

(2015) Tatsuroh Sugiyama et al.   PLoS One

The Thioredoxin Superfamily in Oxidative Protein Folding

(2014) Jun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

(2014) Juliana Navarro-Yepes et al.   ANTIOXIDANTS & REDOX SIGNALING

The yeast autophagy protease Atg4 is regulated by thioredoxin

(2014) María Esther Pérez-Pérez et al.   Autophagy

Organelle-Based Aggregation and Retention of Damaged Proteins in Asymmetrically Dividing Cells

(2014) Chuankai Zhou et al.   CELL

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy

(2014) Michela Pievani et al.   Nature Reviews Neurology

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulated spatial organization and sensitivity of cytosolic protein oxidation in Caenorhabditis elegans

(2014) Catalina Romero-Aristizabal et al.   Nature Communications

The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

(2014) Cendrine Tourette et al.   PLOS BIOLOGY

Molecular chaperones and proteostasis regulation during redox imbalance

(2014) Katerina Niforou et al.   Redox Biology

Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease

(2013) Tali Gidalevitz et al.   BMC BIOLOGY

Functional characterization of thioredoxin 3 (TRX-3), a Caenorhabditis elegans intestine-specific thioredoxin

(2013) María Jiménez-Hidalgo et al.   FREE RADICAL BIOLOGY AND MEDICINE

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

(2013) Eyleen J. O’Rourke et al.   NATURE CELL BIOLOGY

Diversity in the origins of proteostasis networks — a driver for protein function in evolution

(2013) Evan T. Powers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Glutathione Reductase GSR-1 Determines Stress Tolerance and Longevity in Caenorhabditis elegans

(2013) Kai Lüersen et al.   PLoS One

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

The Characterization of the Caenorhabditis elegans Mitochondrial Thioredoxin System Uncovers an Unexpected Protective Role of Thioredoxin Reductase 2 in β-Amyloid Peptide Toxicity

(2012) Briseida Cacho-Valadez et al.   ANTIOXIDANTS & REDOX SIGNALING

Functions and Cellular Compartmentation of the Thioredoxin and Glutathione Pathways in Yeast

(2012) Michel B. Toledano et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein Carbonylation and Aggregation Precede Neuronal Apoptosis Induced by Partial Glutathione Depletion

(2012) Anushka Dasgupta et al.   ASN Neuro

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

(2012) Gawain McColl et al.   Molecular Neurodegeneration

Stress and aging induce distinct polyQ protein aggregation states

(2012) L. E. Moronetti Mazzeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system

(2012) Lin Zheng et al.   Translational Neurodegeneration

Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans

(2011) Patricia Back et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans : rescue by the DAF-16 and HSF-1 pathways

(2011) Andreia Teixeira-Castro et al.   HUMAN MOLECULAR GENETICS

Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans

(2011) J. Stenvall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Atg8: an autophagy-related ubiquitin-like protein family

(2011) Tomer Shpilka et al.   GENOME BIOLOGY

C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms

(2010) Ye Tian et al.   CELL

ccz-1 mediates the digestion of apoptotic corpses in C. elegans

(2010) C. Nieto et al.   JOURNAL OF CELL SCIENCE

Microtubules Regulate Migratory Polarity through Rho/ROCK Signaling in T Cells

(2010) Aya Takesono et al.   PLoS One

Heat stress upregulates chaperone heat shock protein 70 and antioxidant manganese superoxide dismutase through reactive oxygen species (ROS), p38MAPK, and Akt

(2009) Soumyajit Banerjee Mustafi et al.   CELL STRESS & CHAPERONES

Gene regulatory logic of dopamine neuron differentiation

(2009) Nuria Flames et al.   NATURE

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

(2008) John J. Mieyal et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox compartmentalization in eukaryotic cells

(2008) Young-Mi Go et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cell motility through plasma membrane blebbing

(2008) Oliver T. Fackler et al.   JOURNAL OF CELL BIOLOGY

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

(2008) S. Hamamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics