The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Fully Human Inhibitory Monoclonal Antibody to the Wnt Receptor RYK

(2013) Michael M. Halford et al.   PLoS One

Wnt5a Regulates Hematopoietic Stem Cell Proliferation and Repopulation Through the Ryk Receptor

(2013) Benjamin J. Povinelli et al.   STEM CELLS

FOXO3 Shares Common Targets with ASCL1 Genome-wide and Inhibits ASCL1-Dependent Neurogenesis

(2013) Ashley E. Webb et al.   Cell Reports

Pathways to decoding the clinical potential of stress response FOXO-interaction networks for Huntington's disease: of gene prioritization and context dependence

(2013) Frédéric Parmentier et al.   Frontiers in Aging Neuroscience

Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons

(2012) François-Xavier Lejeune et al.   BMC GENOMICS

Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes

(2012) The HD iPSC Consortium   Cell Stem Cell

The Wnt Coreceptor Ryk Regulates Wnt/Planar Cell Polarity by Modulating the Degradation of the Core Planar Cell Polarity Component Vangl2

(2012) Philipp Andre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling

(2012) Maria L. Macheda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integration of  -Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity

(2012) J. A. Parker et al.   JOURNAL OF NEUROSCIENCE

Reinduced Wnt signaling limits regenerative potential of sensory axons in the spinal cord following conditioning lesion

(2012) E. R. Hollis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role and Therapeutic Potential of the Pro-Longevity Factor FOXO and Its Regulators in Neurodegenerative Disease

(2012) Christian Neri   Frontiers in Pharmacology

The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development

(2011) J. Zhong et al.   DEVELOPMENT

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling

(2011) Jason D. Berndt et al.   JOURNAL OF CELL BIOLOGY

Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors

(2011) Kimberly B Kegel et al.   Molecular Neurodegeneration

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

(2010) Elizabeth A. Thomas et al.   HUMAN MOLECULAR GENETICS

Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease

(2010) John P. Miller et al.   NEURON

FoxO3 Regulates Neural Stem Cell Homeostasis

(2009) Valérie M. Renault et al.   Cell Stem Cell

Cdc37 Regulates Ryk Signaling by Stabilizing the Cleaved Ryk Intracellular Domain

(2009) Jungmook Lyu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO3a Is Broadly Neuroprotective In Vitro and In Vivo against Insults Implicated in Motor Neuron Diseases

(2009) J. Mojsilovic-Petrovic et al.   JOURNAL OF NEUROSCIENCE

Emerging roles of Wnts in the adult nervous system

(2009) Nibaldo C. Inestrosa et al.   NATURE REVIEWS NEUROSCIENCE

Upregulation of Ryk expression in rat dorsal root ganglia after peripheral nerve injury

(2008) Xin Li et al.   BRAIN RESEARCH BULLETIN

FoxO transcription factors in the maintenance of cellular homeostasis during aging

(2008) Dervis AM Salih et al.   CURRENT OPINION IN CELL BIOLOGY

Cleavage of the Wnt Receptor Ryk Regulates Neuronal Differentiation during Cortical Neurogenesis

(2008) Jungmook Lyu et al.   DEVELOPMENTAL CELL

Mechanisms of neurodegeneration in Huntington’s disease

(2008) Joana M. Gil et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Repulsive Wnt Signaling Inhibits Axon Regeneration after CNS Injury

(2008) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice

(2008) M.A. Hickey et al.   NEUROSCIENCE

Phospholipase C-ε Regulates Epidermal Morphogenesis in Caenorhabditis elegans

(2008) Rafael P. Vázquez-Manrique et al.   PLoS Genetics