Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A  Generation and Amyloid Plaque Pathogenesis

(2015) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy

(2015) Gururaj Joshi et al.   NEUROBIOLOGY OF AGING

BAG3 facilitates the clearance of endogenous tau in primary neurons

(2015) Zhinian Lei et al.   NEUROBIOLOGY OF AGING

SUMO1 promotes Aβ production via the modulation of autophagy

(2014) Sun-Jung Cho et al.   Autophagy

Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: Findings from 3-D melanoma skin equivalents and computational modeling

(2014) Deeba N. Syed et al.   BIOCHEMICAL PHARMACOLOGY

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

(2014) V. A. Polito et al.   EMBO Molecular Medicine

Regulatory Effects of Fisetin on Microglial Activation

(2014) Jing-Yuan Chuang et al.   MOLECULES

Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice

(2013) Antonio Currais et al.   AGING CELL

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Concurrent regulation of the transcription factors Nrf2 and ATF4 mediates the enhancement of glutathione levels by the flavonoid fisetin

(2013) Jennifer L. Ehren et al.   BIOCHEMICAL PHARMACOLOGY

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

What Renders TAU Toxic

(2013) Jürgen Götz et al.   Frontiers in Neurology

Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management

(2012) Vaqar Mustafa Adhami et al.   BIOCHEMICAL PHARMACOLOGY

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Tau-targeted treatment strategies in Alzheimer's disease

(2011) Jürgen Götz et al.   BRITISH JOURNAL OF PHARMACOLOGY

The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

(2011) Susanne M. Pritchard et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau

(2011) Song-In Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Autophagic degradation of tau in primary neurons and its enhancement by trehalose

(2011) Ulrike Krüger et al.   NEUROBIOLOGY OF AGING

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway

(2010) Philip J. Dolan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

(2008) Tadanori Hamano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity

(2008) Long Tai Zheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

(2008) J. Ramesh Babu et al.   JOURNAL OF NEUROCHEMISTRY