Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia

Early striatal amyloid deposition distinguishes Down syndrome and autosomal dominant Alzheimer's disease from late-onset amyloid deposition

(2018) Ann D. Cohen et al.   Alzheimers & Dementia

The correlation between striatal and cortical binding ratio of 11C-PiB-PET in amyloid-uptake-positive patients

(2018) Julia Sauerbeck et al.   ANNALS OF NUCLEAR MEDICINE

Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease

(2018) Chelsea T Tiernan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study

(2018) Elliott J. Mufson et al.   JOURNAL OF NEUROTRAUMA

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain

(2018) Sarah L. DeVos et al.   Frontiers in Neuroscience

The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer’s disease in individuals with Down syndrome

(2018) Yvonne S. Davidson et al.   Acta Neuropathologica Communications

Comparison of longitudinal Aβ in non-demented elderly and Down syndrome

(2018) Dana L. Tudorascu et al.   NEUROBIOLOGY OF AGING

HDAC2 dysregulation in the nucleus basalis of Meynert during the progression of Alzheimer's disease

(2018) Laura Mahady et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: Correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer's disease

(2017) Stephen D. Ginsberg et al.   HIPPOCAMPUS

PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)

(2017) Michael S. Rafii et al.   JOURNAL OF ALZHEIMERS DISEASE

Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan

(2017) Harry LeVine et al.   NEUROBIOLOGY OF AGING

Laminar and Cellular Distribution of Monoamine Receptors in Rat Medial Prefrontal Cortex

(2017) Noemí Santana et al.   Frontiers in Neuroanatomy

Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer’s Disease

(2017) Ni-Chung Lee et al.   Frontiers in Aging Neuroscience

Characterization of TauC3 antibody and demonstration of its potential to block tau propagation

(2017) Samantha B. Nicholls et al.   PLoS One

Hyperphosphorylation determines both the spread and the morphology of tau pathology

(2016) Wen Hu et al.   Alzheimers & Dementia

The pattern of amyloid accumulation in the brains of adults with Down syndrome

(2016) Tiina Annus et al.   Alzheimers & Dementia

An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation

(2016) M. Florencia Iulita et al.   Alzheimers & Dementia

The effects of normal aging on amyloid-β deposition in nondemented adults with Down syndrome as imaged by carbon 11–labeled Pittsburgh compound B

(2016) Patrick J. Lao et al.   Alzheimers & Dementia

Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease

(2016) Elena Rodriguez-Vieitez et al.   BRAIN

Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study

(2016) Elliott J. Mufson et al.   BRAIN INJURY

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

SIRT6, oxidative stress and aging

(2016) Chen-Yu Liao et al.   CELL RESEARCH

Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease

(2016) Chelsea T. Tiernan et al.   NEUROBIOLOGY OF AGING

Early Alzheimer's disease–type pathology in the frontal cortex of wild mountain gorillas ( Gorilla beringei beringei )

(2016) Sylvia E. Perez et al.   NEUROBIOLOGY OF AGING

Sirtuins at the Breaking Point: SIRT6 in DNA Repair

(2016) David B. Lombard   Aging-US

An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome

(2016) Faycal Guedj et al.   Scientific Reports

Resilience of Precuneus Neurotrophic Signaling Pathways Despite Amyloid Pathology in Prodromal Alzheimer’s Disease

(2015) Sylvia E. Perez et al.   BIOLOGICAL PSYCHIATRY

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

(2015) Elizabeth Head et al.   Current Alzheimer Research

Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome

(2015) J. L. Shaw et al.   JOURNAL OF NEUROSCIENCE

Age dependence of brain  -amyloid deposition in Down syndrome: An [18F]florbetaben PET study

(2015) D. Jennings et al.   NEUROLOGY

Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease

(2015) Jon B. Toledo et al.   JAMA Neurology

Nerve growth factor metabolic dysfunction in Down’s syndrome brains

(2014) M. Florencia Iulita et al.   BRAIN

Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome

(2014) Sigan L. Hartley et al.   BRAIN

Regional analysis of striatal and cortical amyloid deposition in patients with Alzheimer's disease

(2014) Kenji Ishibashi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dementia diagnostic criteria in Down syndrome

(2014) Rory Sheehan et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Autoimmune Predisposition in Down Syndrome May Result from a Partial Central Tolerance Failure due to Insufficient Intrathymic Expression ofAIREand Peripheral Antigens

(2014) Mireia Giménez-Barcons et al.   JOURNAL OF IMMUNOLOGY

Cerebral perfusion alterations and cerebral amyloid in autosomal dominant Alzheimer disease

(2014) E. McDade et al.   NEUROLOGY

Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla)

(2013) Sylvia E. Perez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer's disease

(2013) M.-Marsel Mesulam   JOURNAL OF COMPARATIVE NEUROLOGY

Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

(2013) S. Mondragón-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment

(2013) Scott E. Counts et al.   NEUROPHARMACOLOGY

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B

(2012) Benjamin L. Handen et al.   Alzheimers & Dementia

Tau oligomers and tau toxicity in neurodegenerative disease

(2012) Sarah M. Ward et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers

(2012) M. Scholl et al.   NEUROLOGY

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior

(2012) Marina R. Picciotto et al.   NEURON

Progression of Tau Pathology in Cholinergic Basal Forebrain Neurons in Mild Cognitive Impairment and Alzheimer's Disease

(2011) Laurel Vana et al.   AMERICAN JOURNAL OF PATHOLOGY

Rac1b Increases with Progressive Tau Pathology within Cholinergic Nucleus Basalis Neurons in Alzheimer's Disease

(2011) Sylvia E. Perez et al.   AMERICAN JOURNAL OF PATHOLOGY

Using Positron Emission Tomography and Carbon 11–Labeled Pittsburgh Compound B to Image Brain Fibrillar β-Amyloid in Adults With Down Syndrome

(2011) Jennifer Landt   ARCHIVES OF NEUROLOGY

Characterization of Prefibrillar Tau Oligomersin Vitroand in Alzheimer Disease

(2011) Kristina R. Patterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

(2011) N. M. Kanaan et al.   JOURNAL OF NEUROSCIENCE

Microarray Analysis of Hippocampal CA1 Neurons Implicates Early Endosomal Dysfunction During Alzheimer's Disease Progression

(2010) Stephen D. Ginsberg et al.   BIOLOGICAL PSYCHIATRY

Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity

(2010) Scott E. Counts et al.   JOURNAL OF NEUROCHEMISTRY

Change in plasma A  peptides and onset of dementia in adults with Down syndrome

(2010) N. Schupf et al.   NEUROLOGY

High Striatal Amyloid β-Peptide Deposition Across Different Autosomal Alzheimer Disease Mutation Types

(2009) Victor L. Villemagne et al.   ARCHIVES OF NEUROLOGY

Accumulation of Aspartic Acid421- and Glutamic Acid391-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

(2009) Gustavo Basurto-Islas et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

(2008) Jerzy Wegiel et al.   ACTA NEUROPATHOLOGICA

Carbon 11–Labeled Pittsburgh Compound B Positron Emission Tomographic Amyloid Imaging in Patients With APP Locus Duplication

(2008) Anne M. Remes et al.   ARCHIVES OF NEUROLOGY

PET amyloid ligand [11C]PIB uptake shows predominantly striatal increase in variant Alzheimer's disease

(2008) J. Koivunen et al.   BRAIN

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

(2008) Milos D. Ikonomovic et al.   BRAIN

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

(2008) Fei Liu et al.   FASEB JOURNAL

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease

(2008) Siddhartha Mondragón-Rodríguez et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Terminal continuation (TC) RNA amplification without second strand synthesis

(2008) Melissa J. Alldred et al.   JOURNAL OF NEUROSCIENCE METHODS

Amyloid β concentrations in older people with Down syndrome and dementia

(2008) Emma L. Jones et al.   NEUROSCIENCE LETTERS