Article
Neurosciences
Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian
Summary: Longitudinal imaging studies in adults with Down syndrome identified A beta accumulation trajectories and early accumulation sites; A beta(-) group, A beta converters, and A beta (+) group showed differences in A beta(L) change; Model images and A beta(L) change values can better identify subthreshold A beta accumulation in DS.
Article
Clinical Neurology
Eric E. Abrahamson, Julia K. Kofler, Carl R. Becker, Julie C. Price, Kathy L. Newell, Bernardino Ghetti, Jill R. Murrell, Catriona A. McLean, Oscar L. Lopez, Chester A. Mathis, William E. Klunk, Victor L. Villemagne, Milos D. Ikonomovic
Summary: In a post-mortem study, it has been found that the amyloid PET radioligand Pittsburgh compound B (PiB) interacts poorly with cotton wool plaques, which are common in familial Alzheimer's disease but rare in sporadic Alzheimer's disease. This limited interaction may lead to an underestimation of total amyloid burden in patients with familial Alzheimer's disease.
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques for identifying early stage Alzheimer's disease, with mass spectrometry plasma measures performing significantly better than other measures.
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques to detect amyloid PET positivity in dementia-free individuals, finding that mass spectrometry plasma measures performed significantly better than other measures, with higher sensitivity and specificity for detecting amyloid PET positivity.
Article
Geriatrics & Gerontology
Violetta N. Pivtoraiko, Tamara Racic, Eric E. Abrahamson, Victor L. Villemagne, Benjamin L. Handen, Ira T. Lott, Elizabeth Head, Milos D. Ikonomovic
Summary: Individuals with Down syndrome (DS) have a different molecular profile of A beta forms compared to late-onset Alzheimer's disease (AD) cases, with a higher preponderance of pyroglutamate-modified A beta NpE3-40 and unmodified A beta 40 forms. Despite greater vascular amyloidosis in DS cases, cortical H-3-PiB binding does not distinguish between diagnostic groups at an advanced level of amyloid plaque pathology.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Shizuo Hatashita, Daichi Wakebe
Summary: This study found that some initially amyloid-negative non-demented subjects converted to globally amyloid-positive during a long-term follow-up, with some association with the APOE epsilon 4 allele. Early regional increases in PIB DVR were most frequently observed in the right lateral temporal cortex.
Article
Geriatrics & Gerontology
Chushu Shen, Zhenguo Wang, Hongzhao Chen, Yan Bai, Xiaochen Li, Dong Liang, Xin Liu, Hairong Zheng, Meiyun Wang, Yongfeng Yang, Haifeng Wang, Tao Sun
Summary: This study proposes a measurement method called Amyloid Quantification Index (AQI) for the diagnosis of Alzheimer's disease. By combining clearance rate and early-phase kinetic information, it can effectively differentiate between healthy individuals and those with AD within a 30-minute scan.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Sigan L. Hartley, Victoria Fleming, Emily K. Schworer, Jamie Peven, Benjamin L. Handen, Sharon Krinsky-McHale, Christy Hom, Laisze Lee, Dana L. Tudorascu, Charles Laymon, Davneet Minhas, Weiquan Luo, Annie Cohen, Shahid Zaman, Beau M. Ances, Mark Mapstone, Elizabeth Head, Florence Lai, H. Diana Rosas, William Klunk, Bradley Christian
Summary: This study aimed to investigate whether premorbid intellectual disability level was associated with the variability in age-trajectories of Alzheimer's disease biomarkers and cognitive impairments. The results showed no significant effect of premorbid intellectual disability level on the trajectories of Alzheimer's disease biomarkers and cognitive outcomes.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Editorial Material
Neurosciences
Poul F. Hoilund-Carlsen, Abass Alavi
Summary: This article discusses the mechanism of action of the FDA-approved anti-Alzheimer drug and the authors' view on the role of amyloid deposits in the progression of the disease.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Neurosciences
Qing Zhao, Xinxin Du, Wenhong Chen, Ting Zhang, Zhuo Xu
Summary: Alzheimer's disease is a global health issue with significant negative impacts. PET/CT and neuropsychological scales are useful for early identification and diagnosis, as well as offering early therapies. There is a lack of large-scale investigations focusing on the pathology of AD and MCI, hence further research is needed to understand the interaction between neuropsychological test scales and PET/CT measurements of disease progression.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Aurora Veteleanu, Sarah Pape, Kate Davies, Eleftheria Kodosaki, Abdul Hye, Wioleta M. Zelek, Andre Strydom, B. Paul Morgan
Summary: Complement dysregulation is present in individuals with Down syndrome, likely indicating a generalized immune dysregulation state; complement biomarkers differ in individuals with Down syndrome with and without Alzheimer's disease and may be used for diagnosis and/or prediction.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Joyce R. Chong, Nicholas J. Ashton, Thomas K. Karikari, Tomotaka Tanaka, Michael Scholl, Henrik Zetterberg, Kaj Blennow, Christopher P. Chen, Mitchell K. P. Lai
Summary: Recent research efforts have focused on discovering and developing clinically useful biomarkers for AD and related dementias. While advancements in blood-based biomarkers hold promise for diagnosis, prognosis, and clinical trial outcome assessments, further studies are needed to establish A beta and P-tau as blood-based biomarkers for AD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Review
Chemistry, Multidisciplinary
Stina Syvanen, Silvio R. Meier, Sahar Roshanbin, Mengfei Xiong, Rebecca Faresjo, Tobias Gustavsson, Gillian Bonvicini, Eva Schlein, Ximena Aguilar, Ulrika Julku, Jonas Eriksson, Dag Sehlin
Summary: Positron emission tomography (PET) is a medical imaging technique that has become important in clinical trials of drugs against Alzheimer's disease (AD). PET data contributed to the approval of aducanumab, an antibody targeting amyloid-beta (A beta) aggregates, by showing a dose-dependent reduction in brain amyloid. PET is also useful in preclinical studies with animal models of A beta pathology. It allows for longitudinal studies and has high translatability between species.
PHARMACEUTICAL RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
MiaoMiao Xu, Jun Guo, JiaCheng Gu, LinLin Zhang, ZiHao Liu, Lin Ding, HongLiang Fu, YuFei Ma, Sheng Liang, Hui Wang
Summary: A new Aβ tracer [F-18]DRKXH1 was synthesized and evaluated for its performance in diagnosing AD using various methods. The tracer showed promising results in detecting Aβ plaques in the brains of AD transgenic mice and AD patients, suggesting its potential for in vivo detection of the human brain.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Claes Nohr Ladefoged, Lasse Anderberg, Karine Madsen, Otto Molby Henriksen, Steen Gregers Hasselbalch, Flemming Littrup Andersen, Liselotte Hojgaard, Ian Law, Alzheimers Dis Neuroimaging Initiat
Summary: In this study, deep learning was used to quantify brain amyloid accumulation and classify amyloid status based on PET images. The results showed that this method can accurately classify and is highly consistent with expert judgment.
Article
Clinical Neurology
Nada Andelic, Cecilie Roe, Cathrine Brunborg, Marina Zeldovich, Marianne Lovstad, Daniel Loke, Ida M. Borgen, Daphne C. Voormolen, Emilie Howe, Marit Forslund, Hilde M. Dahl, Nicole von Steinbuechel
Summary: Fatigue is a common and stable symptom experienced by TBI patients during the first 6 months post-injury, with specific predictors including injury severity, demographic characteristics, and comorbidities. Patients admitted to ICU, females, younger individuals with higher education, severe intracranial injury, preinjury somatic and psychiatric conditions, sleep disturbance, and post-injury depression are more likely to experience fatigue.
JOURNAL OF NEUROLOGY
(2021)
Letter
Critical Care Medicine
Virginia F. J. Newcombe, Lennart R. B. Spindler, Tilak Das, Stefan Winzeck, Kieren Allinson, Emmanuel A. Stamatakis, David K. Menon
INTENSIVE CARE MEDICINE
(2021)
Review
Geriatrics & Gerontology
Joshua Flavell, Peter J. Nestor
Summary: Depression and apathy are common in PSP patients, with depression prevalence influenced by apathy and most apathy studies relying on screening question methods.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2022)
Article
Emergency Medicine
Catherine Ashton, M. Laffan, P. J. Hutchinson, Fiona Lecky, S. Ralhan, Jason E. Smith, Jonathan P. Coles, Simon Stanworth, Nicola Curry
Summary: There is clinical equipoise about the role of platelet transfusion in patients with traumatic intracranial hemorrhage (ICH) who are taking antiplatelet medications. Further trials are needed to investigate the effect of platelet transfusion in this high-risk patient population.
EMERGENCY MEDICINE JOURNAL
(2022)
Article
Clinical Neurology
Abdalla Z. Mohamed, Peter J. Nestor, Paul Cumming, Fatima A. Nasrallah
Summary: In this study, individuals with a history of remote traumatic brain injury (TBI) were found to have an earlier onset of cognitive impairment, greater amyloid deposition, and more pronounced cortical thinning along the Alzheimer's disease continuum.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Marian Galovic, Kjell Erlandsson, Tim D. Fryer, Young T. Hong, Roido Manavaki, Hasan Sari, Sarah Chetcuti, Benjamin A. Thomas, Martin Fisher, Selena Sephton, Roberto Canales, Joseph J. Russell, Kerstin Sander, Erik Arstad, Franklin I. Aigbirhio, Ashley M. Groves, John S. Duncan, Kris Thielemans, Brian F. Hutton, Jonathan P. Coles, Matthias J. Koepp
Summary: Blood-based kinetic analysis of PET data relies on an accurate estimation of the arterial plasma input function. An alternative is the image-derived input function (IDIF), which can be corrected for the required free tracer concentration in plasma. The IDIF + venous method provides comparable results to arterial sampling, making it a viable alternative for quantification of V-T.
Article
Emergency Medicine
Charlie Aletta Sewalt, Benjamin Yael Gravesteijn, David Menon, Hester Floor Lingsma, Andrew I. R. Maas, Nino Stocchetti, Esmee Venema, Fiona E. Lecky
Summary: This study assessed variation in levels of early secondary referral within European specialist neurotrauma care centers and compared outcomes of directly admitted and secondarily transferred patients. The findings indicate substantial practice variation across Europe in the proportion of secondarily referred traumatic brain injury patients at specialist neurotrauma care centers, with early secondary referral not showing a significant impact on functional outcome and survival after stabilisation in a non-specialised hospital. Future research is needed to determine which TBI patients truly benefit from direct transportation.
SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Falk Luesebrink, Hendrik Mattern, Renat Yakupov, Julio Acosta-Cabronero, Mohammad Ashtarayeh, Steffen Oeltze-Jafra, Oliver Speck
Summary: This study presents an extension of a structural ultrahigh resolution MRI dataset, including various additional ultrahigh resolution contrasts acquired from the same participant on a 7T scanner over ten years. The dataset comprises a comprehensive collection of multiple imaging techniques and resolutions for further investigation.
Letter
Clinical Neurology
Peter J. Nestor
Article
Geriatrics & Gerontology
Stephanie S. G. Brown, Elijah Mak, Isabel Clare, Monika Grigorova, Jessica Beresford-Webb, Madeline Walpert, Elizabeth Jones, Young T. Hong, Tim D. Fryer, Jonathan P. Coles, Franklin I. Aigbirhio, Dana Tudorascu, Annie Cohen, Bradley T. Christian, Benjamin L. Handen, William E. Klunk, David K. Menon, Peter J. Nestor, Anthony J. Holland, Shahid H. Zaman
Summary: This study used diffusion-weighted imaging and connectomic modeling to assess the predictive ability of brain amyloid plaque burden, baseline cognition, and longitudinal cognitive change in individuals with Down's syndrome. The findings suggest that graph theory metrics based on the structural connectome are effective predictors of global amyloid deposition, and the connection density of the structural network at baseline is a promising predictor of current cognitive performance.
NEUROBIOLOGY OF AGING
(2022)
Article
Clinical Neurology
Ornella Billette, Gabriel Ziegler, Merita Aruci, Hartmut Schuetze, Jasmin M. Kizilirmak, Anni Richter, Slawek Altenstein, Claudia Bartels, Frederic Brosseron, Arturo Cardenas-Blanco, Philip Dahmen, Peter Dechent, Laura Dobisch, Klaus Fliessbach, Silka Dawn Freiesleben, Wenzel Glanz, Doreen Goeerss, John Dylan Haynes, Michael T. Heneka, Ingo Kilimann, Okka Kimmich, Luca Kleineidam, Christoph Laske, Andrea Lohse, Ayda Rostamzadeh, Coraline Metzger, Matthias H. Munk, Oliver Peters, Lukas Preis, Josef Priller, Klaus Scheffler, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Alfredo Ramirez, Sandra Roeske, Nina Roy, Stefan Teipel, Michael Wagner, Jens Wiltfang, Steffen Wolfsgruber, Renat Yakupov, Peter Zeidman, Frank Jessen, Bjorn H. Schott, Emrah Duezel, Anne Maass
Summary: This study aimed to assess whether neuroimaging characteristics follow an inverted U-shaped pattern across the clinical spectrum of increased Alzheimer disease (AD) risk. The study found that novelty-related activity in the precuneus showed a nonlinear pattern, with higher activity in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI), but lower activity in patients with AD. The activity differences were not related to AD biomarkers or brain volume. However, hippocampal activity was reduced in patients with AD and related to AD biomarkers.
Meeting Abstract
Psychiatry
J. Flavell, C. Franklin, P. J. Nestor
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Samuel Shribman, Martina Bocchetta, Carole H. Sudre, Julio Acosta-Cabronero, Maggie Burrows, Paul Cook, David L. Thomas, Godfrey T. Gillett, Emmanuel A. Tsochatzis, Oliver Bandmann, Jonathan D. Rohrer, Thomas T. Warner
Summary: Wilson's disease is a genetic disorder that affects copper metabolism and can lead to neurological and hepatic symptoms. This study used neuroimaging techniques to analyze brain abnormalities in patients with Wilson's disease and found differences between those with neurological and hepatic presentations. The severity of neurological deficits was correlated with reductions in grey matter volume in certain brain regions. Additionally, the study identified associations between neurological severity and changes in white matter integrity and iron deposition. These findings provide insights into the disease mechanisms and suggest potential biomarkers for prognosis and monitoring.
Article
Clinical Neurology
Elijah Mak, Monika Grigorova, Jessica Beresford-Webb, Maura Malpetti, Madeline Walpert, Stephanie Brown, Elizabeth Jones, Isabel Clare, Young T. Hong, Tim D. Fryer, Jonathan P. Coles, Franklin Aigbirhio, David K. Menon, Peter J. Nestor, Anthony J. Holland, Shahid H. Zaman
Summary: The study found significant and widespread reductions of cerebral perfusion in individuals with elevated amyloid burden in Down syndrome, independent of age, gender, cognitive function, and cortical thickness. Additionally, cerebral perfusion was associated with cognitive impairment in individuals with elevated amyloid burden, highlighting the promising utility of relative tracer delivery of [C-11]-Pittsburgh Compound B as a surrogate index in clinical trials.
BRAIN COMMUNICATIONS
(2021)
Article
Critical Care Medicine
Jilske A. Huijben, Abhishek Dixit, Nino Stocchetti, Andrew I. R. Maas, Hester F. Lingsma, Mathieu van der Jagt, David Nelson, Giuseppe Citerio, Lindsay Wilson, David K. Menon, Ari Ercole
Summary: Variation in high Therapy Intensity Level (TIL) treatments for traumatic brain injury (TBI) patients with elevated intracranial pressure (ICP) across European Intensive Care Units (ICUs) was found, with escalation to higher TIL treatments often not preceded by lower TIL treatments. 38% of patients receiving high TIL treatments had favorable outcomes, but sensitivity analysis suggested a significant association with worse outcomes in some cases.
