Phenome-driven disease genetics prediction toward drug discovery

Comparative analysis of a novel disease phenotype network based on clinical manifestations

(2015) Yang Chen et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Inductive matrix completion for predicting gene-disease associations

(2014) N. Natarajan et al.   BIOINFORMATICS

In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease

(2014) Raja Atreya et al.   NATURE MEDICINE

Computational Drug Repositioning: From Data to Therapeutics

(2013) M R Hurle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

An immunological link betweenCandida albicanscolonization and Crohn’s disease

(2013) Romain Gerard et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Effect of Thalidomide on Clinical Remission in Children and Adolescents With Refractory Crohn Disease

(2013) Marzia Lazzerini et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

(2013) Christopher Lupfer et al.   NATURE IMMUNOLOGY

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

Computational approaches to disease-gene prediction: rationale, classification and successes

(2012) Rosario M. Piro et al.   FEBS Journal

Human conditions of insulin-like growth factor-I (IGF-I) deficiency

(2012) Juan E Puche et al.   Journal of Translational Medicine

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Computational tools for prioritizing candidate genes: boosting disease gene discovery

(2012) Yves Moreau et al.   NATURE REVIEWS GENETICS

Co-clustering phenome–genome for phenotype classification and disease gene discovery

(2012) TaeHyun Hwang et al.   NUCLEIC ACIDS RESEARCH

Uncover disease genes by maximizing information flow in the phenome-interactome network

(2011) Y. Chen et al.   BIOINFORMATICS

Network-based methods for human disease gene prediction

(2011) X. Wang et al.   Briefings in Functional Genomics

Epidemiology and Natural History of Inflammatory Bowel Diseases

(2011) Jacques Cosnes et al.   GASTROENTEROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

PhenomeNET: a whole-phenome approach to disease gene discovery

(2011) R. Hoehndorf et al.   NUCLEIC ACIDS RESEARCH

A Novel Role for the NLRC4 Inflammasome in Mucosal Defenses against the Fungal Pathogen Candida albicans

(2011) Jeffrey Tomalka et al.   PLoS Pathogens

Potential Association Between the Oral Tetracycline Class of Antimicrobials Used to Treat Acne and Inflammatory Bowel Disease

(2010) David J Margolis et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Genome-wide inferring gene–phenotype relationship by walking on the heterogeneous network

(2010) Yongjin Li et al.   BIOINFORMATICS

A guide to web tools to prioritize candidate genes

(2010) L.-C. Tranchevent et al.   BRIEFINGS IN BIOINFORMATICS

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

(2010) Simon A. Hirota et al.   INFLAMMATORY BOWEL DISEASES

Effectiveness and Safety of Tocilizumab, an Anti–Interleukin-6 Receptor Monoclonal Antibody, in a Patient With Refractory GI Graft-Versus-Host Disease

(2010) Usama Gergis et al.   JOURNAL OF CLINICAL ONCOLOGY

Phenomics: the next challenge

(2010) David Houle et al.   NATURE REVIEWS GENETICS

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Systems Pharmacology of Arrhythmias

(2010) S. I. Berger et al.   Science Signaling

Associating Genes and Protein Complexes with Disease via Network Propagation

(2010) Oron Vanunu et al.   PLoS Computational Biology

IL-1β Processing in Host Defense: Beyond the Inflammasomes

(2010) Mihai G. Netea et al.   PLoS Pathogens

Mecasermin (recombinant human insulin-like growth factor I)

(2009) Arlan L. Rosenbloom   ADVANCES IN THERAPY

Candida albicans Colonization and ASCA in Familial Crohn's Disease

(2009) Annie Standaert-Vitse et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Biological Coherence of Human Phenome Databases

(2009) Martin Oti et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Advances in translational bioinformatics: computational approaches for the hunting of disease genes

(2009) M. G. Kann   BRIEFINGS IN BIOINFORMATICS

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy of tricyclic antidepressants in irritable bowel syndrome: A meta-analysis

(2009) Roja Rahimi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Linking genes to diseases: it's all in the data

(2009) Nicki Tiffin et al.   Genome Medicine

Walking the Interactome for Prioritization of Candidate Disease Genes

(2008) Sebastian Köhler et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Human Phenotype Ontology: A Tool for Annotating and Analyzing Human Hereditary Disease

(2008) Peter N. Robinson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Align human interactome with phenome to identify causative genes and networks underlying disease families

(2008) Xuebing Wu et al.   BIOINFORMATICS

Network-based global inference of human disease genes

(2008) Xuebing Wu et al.   Molecular Systems Biology

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

Human Protein Reference Database--2009 update

(2008) T. S. Keshava Prasad et al.   NUCLEIC ACIDS RESEARCH

Phenome connections

(2008) Martin Oti et al.   TRENDS IN GENETICS