Review
Gastroenterology & Hepatology
Vivek C. Goodoory, Mais Khasawneh, Christopher J. Black, Eamonn M. M. Quigley, Paul Moayyedi, Alexander C. Ford
Summary: This article conducted a meta-analysis to study the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). The study found that certain combinations of probiotics or strains may be beneficial for IBS, but the certainty of the evidence was low.
Review
Gastroenterology & Hepatology
Maria Rosa Ingrosso, Gianluca Ianiro, Judy Nee, Anthony J. Lembo, Paul Moayyedi, Christopher J. Black, Alexander C. Ford
Summary: This study aimed to evaluate the efficacy and safety of peppermint oil in the treatment of IBS. The results showed that peppermint oil was more effective than placebo, but adverse events occurred more frequently.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Gastroenterology & Hepatology
Alfred D. Nelson, Christopher J. Black, Lesley A. Houghton, Nahyr Sofia Lugo-Fagundo, Brian E. Lacy, Alexander C. Ford
Summary: In a study of IBS-C patients, it was found that all licensed drugs were more effective than a placebo for abdominal bloating, with linaclotide showing the highest efficacy in relieving this symptom. Further research is needed to understand the long-term efficacy and mechanisms of action of these treatments.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Immunology
Tao Zhang, Cunzheng Zhang, Jindong Zhang, Feng Sun, Liping Duan
Summary: This network meta-analysis found that B.coagulans exhibited significant efficacy in treating IBS patients, L.plantarum ranked first in improving quality of life, and L.acidophilus had the lowest incidence of adverse events. Treatment length significantly influenced the efficacy of probiotics in improving abdominal pain and straining.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Cristian-Ioan Babos, Daniel-Corneliu Leucuta, Dan Lucian Dumitrascu
Summary: This study assessed the effectiveness of meditation/mindfulness in improving symptoms severity, quality of life, and other associated mental conditions in patients with irritable bowel syndrome (IBS). The meta-analysis results showed statistically significant improvements in symptom score, quality of life, spiritual scale, and pain score in the mindfulness group compared to the control group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Georgios Konstantis, Stylianos Efstathiou, Chryssa Pourzitaki, Elisavet Kitsikidou, Georgios Germanidis, Michail Chourdakis
Summary: This meta-analysis evaluated the efficacy and safety of probiotics in IBS-patients. The results showed a significant reduction in abdominal pain and bloating, but no improvement in other parameters. Larger randomized controlled trials are needed to confirm these findings and further investigate the use of specific probiotic strains.
CLINICAL NUTRITION
(2023)
Review
Pediatrics
Somayeh Fatahi, Amirhossein Hosseini, Mohammad Hassan Sohouli, Aliakbar Sayyari, Katayoun Khatami, Zahra Fazeli Farsani, Hamzeh Amiri, Naghi Dara, Ivan G. O. de Souza, Heitor O. Santos
Summary: Probiotic supplementation can reduce abdominal pain in pediatric patients with IBS, with stronger effects seen in patients under 10 years old and longer supplementation periods exceeding four weeks.
WORLD JOURNAL OF PEDIATRICS
(2022)
Review
Medicine, General & Internal
Fei Yao, Xutao Wu, Huacheng Zhao, Chun Gan
Summary: This study aims to resolve the uncertainty regarding the effectiveness of psychological interventions for irritable bowel syndrome (IBS) through systematic review and meta-analysis. It provides a comprehensive analysis of the existing evidence to inform practitioners and policy makers.
Review
Multidisciplinary Sciences
Hua-Lan Xu, Li-Li Zou, Mao-bing Chen, Hua Wang, Wen-Ming Shen, Qi-Han Zheng, Wei-Yan Cui
Summary: This study systematically evaluated the efficacy of probiotic adjuvant therapy for IBS in children and found that probiotics significantly reduce abdominal pain scores, improve Subject's Global Assessment of Relief scores, increase abdominal pain treatment success rates, and reduce the frequency of abdominal pain. However, increasing the intake of probiotics may not relieve abdominal pain.
Review
Nutrition & Dietetics
Peiwei Xie, Mei Luo, Xuehong Deng, Jiahui Fan, Lishou Xiong
Summary: This network meta-analysis compared and ranked the efficacy of different probiotic strains or combinations in treating IBS. It found that certain probiotics were effective in improving specific symptoms of IBS. However, further studies are needed to confirm these results.
Review
Medicine, General & Internal
Michelle Y. Nabi, Samal Nauhria, Morgan Reel, Simon Londono, Anisha Vasireddi, Mina Elmiry, Prakash V. A. K. Ramdass
Summary: The study aimed to estimate the pooled odds ratio of endometriosis and irritable bowel syndrome, and the pooled prevalence of irritable bowel syndrome in patients with endometriosis. The results showed that patients with endometriosis have a threefold increased risk of developing irritable bowel syndrome, and the prevalence of irritable bowel syndrome in women with endometriosis was 23.4%.
FRONTIERS IN MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Christopher Roberts, Ahmed Albusoda, Adam D. Farmer, Qasim Aziz
Summary: This study aimed to determine whether individuals with irritable bowel syndrome (IBS) have lower pain thresholds compared to healthy individuals. The results showed that reduced rectal pain threshold is more common in IBS patients than in healthy controls. Further research is needed to understand the pathophysiological and therapeutic implications of rectal sensitivity in IBS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Xiu-Cai Fang, Wen-Juan Fan, Douglas D. Drossman, Shao-Mei Han, Mei-Yun Ke
Summary: This study compared bowel symptoms and psychosocial features in IBS patients diagnosed with Rome III criteria with abdominal discomfort, abdominal pain, and pain & discomfort. The results showed that IBS patients with abdominal discomfort have similar bowel symptoms and psychosocial features to those with abdominal pain.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Nutrition & Dietetics
Hangkai Huang, Linjie Lu, Yishu Chen, Yan Zeng, Chengfu Xu
Summary: This systematic review and meta-analysis explored the efficacy of vitamin D supplementation in patients with irritable bowel syndrome (IBS). The results indicated that vitamin D supplementation was superior to placebo in improving IBS symptoms and quality of life.
Review
Nutrition & Dietetics
Anne-Sophie van Lanen, Angelika de Bree, Arno Greyling
Summary: The low-FODMAP diet is effective in reducing symptoms severity and improving quality of life in patients with irritable bowel syndrome, regardless of age, intervention duration, and IBS subtype. Future research should focus on the long-term effects of such diets on nutritional adequacy and the gut microbiome.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Engineering, Biomedical
Mona Navaei-Nigjeh, Soheyl Mirzababaei, Mohammad Adel Ghiass, Kaveh Roshanbinfar, Mahdi Gholami, Mohammad Abdollahi
Summary: Islet-laden fibers generated with microfluidic technology can protect pancreatic islet cells from the immune response. Adding mesenchymal stromal cells (MSCs) improves cell function and suppresses the immune response in diabetic rats, leading to better treatment outcomes.
Review
Pharmacology & Pharmacy
Taraneh Mousavi, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: With the rise in aging population and chronic diseases, the use and abuse of opioids have increased worldwide, leading to an increase in opioid-related adverse events, specifically opioid-induced bowel dysfunction. This calls for a rational clinical management strategy.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Engineering, Environmental
Farzaneh Kefayati, Atoosa Karimi Babaahmadi, Taraneh Mousavi, Mahshid Hodjat, Mohammad Abdollahi
Summary: Environmental toxicants can regulate gene expression through epigenetic mechanisms. This article discusses the impact of three epigenetic modifications on seven important categories of diseases and the influence of eleven main environmental factors on epigenetic modifications. These epigenetic-related mechanisms play a crucial role in the development of common diseases, aiding in diagnosis and treatment, as well as predicting transgenerational and intergenerational effects. However, more well-designed research is needed to determine the precise role of environmentally-induced epigenetic alterations in disease etiology.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2023)
Article
Health Care Sciences & Services
Neha Durgam, Ankur A. Dashputre, Olga Moshkovich, Ali Rezaie, Nicholas Martinez, Pedram Enayati, James Stansbury, George Joseph
Summary: The purpose of this study was to develop and validate a new PRO instrument, the SIBO Symptom Measure (SSM) daily diary. The SSM assesses symptom severity in SIBO patients, aiming to provide a PRO tool for endpoint measurement.
QUALITY OF LIFE RESEARCH
(2023)
Review
Obstetrics & Gynecology
Zahra Taghipour, Maryam Bahmanzadeh, Roja Rahimi
Summary: The aim of this study is to investigate the contradictory effects of clove and its phytochemicals on the reproductive system of both males and females. A total of 76 articles were collected and analyzed, revealing the effects of clove and its constituents on sex hormones, fertility, sperm abnormalities, endometriosis, menstrual cycle, gynecological infections, and reproductive tumors. The main mechanism of clove's action remains unclear, but it appears that various factors, such as extraction method, dosage, and duration of administration, as well as the underlying cause of the disorder, can influence its pharmacological activity. More detailed studies are needed to explore the potential therapeutic effects of clove for reproductive disorders.
REPRODUCTIVE SCIENCES
(2023)
Article
Toxicology
Marzieh Daniali, Mona Navaei-Nigjeh, Maryam Baeeri, Soheyl Mirzababaei, Mahdi Gholami, Mahban Rahimifard, Mohammad Abdollahi
Summary: In this study, the protective effects of Levosimendan (LEVO) on pancreatic islets exposed to sodium arsenite (NaAsO2) were investigated. The results showed that LEVO improved the viability and functionality of pancreatic islets and modulated oxidative stress and inflammatory biomarkers.
Review
Toxicology
Sara Mostafalou, Mohammad Abdollahi
Summary: This article reviews the role of organophosphorus (OP) compounds in the development of neurological disorders and explores how genetic variations can affect susceptibility to OP pesticide neurotoxicity. It discusses the various neurological disorders associated with OP compound exposure and the pathological mechanisms involved. Specific genetic polymorphisms have been found to increase the risk of developing OP-related neurological disorders.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Integrative & Complementary Medicine
Roodabeh Bahramsoltani, Zahra Shahpiri, Mohammad Hosein Farzaei, Leila Hosseinzadeh, Davood Rezazadeh, Morteza Pourfarzam, Roja Rahimi
Summary: This study assessed the effects of cinnamon oil, cinnamic acid, and cinnamaldehyde on an in vitro model of Parkinson's disease (PD). The results showed that cinnamon oil and cinnamic acid were able to reverse the abnormalities caused by MPTP in PC-12 cells, supporting the beneficial effect of cinnamon oil in neurodegenerative diseases.
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
(2023)
Review
Biochemistry & Molecular Biology
Shilan Mozaffari, Taraneh Mousavi, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: Polypharmacy is common among elderly patients and can lead to severe drug interactions, posing significant challenges to healthcare providers. Understanding the underlying mechanisms of these interactions and designing personalized treatment plans is crucial.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Review
Pharmacology & Pharmacy
Taraneh Mousavi, Mohammadhossein Sharifnia, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: Acute gastrointestinal cramping pain (GICP) is a common condition that significantly affects people's quality of life. This article explores the treatment options for GICP and discusses the use of antispasmodics as the primary treatment.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Narges Lavari, Nima Ostadrahimi, Roja Rahimi, Mehdi Raei, Alireza Abbassian
Summary: This study aimed to investigate the efficacy of a topical formulation from henna on pain intensity in patients with chronic sciatica. In a randomized, double-blind clinical study, 81 patients were divided into three groups to receive henna formulation, sesame oil, or placebo for four weeks. The results showed that the henna formulation significantly reduced pain intensity compared to sesame oil and placebo. It also improved quality of life and functional ability. Further randomized controlled trials with longer intervention periods are recommended to confirm its efficacy.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Toxicology
Nader Rahimi Kakavandi, Taraneh Mousavi, Tayebeh Asadi, Ayda Moradi, Mahta Esmaeili, Ahmad Habibian Sezavar, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: This study conducted a systematic review and dose-response meta-analysis on the association between arsenic exposure and the risk of type 2 diabetes. The results showed that arsenic in drinking water and urine were significantly associated with the risk of type 2 diabetes.
TOXICOLOGY LETTERS
(2023)
Article
Psychiatry
Ali Amirkafi, Faezeh Mohammadi, Arash Tehrani-Banihashemi, Maziar Moradi-Lakeh, Christopher J. L. Murray, Mohsen Naghavi, Ali H. Mokdad
Summary: The study investigates drug use disorders as a significant contributor to Disability Adjusted Life Years (DALYs) in the Eastern Mediterranean Region (EMR). The findings reveal a significant increase in the prevalence of drug use disorders since 1990, with opioid use being the most prevalent disorder. United Arab Emirates, Libya, and Iran are among the countries most affected by drug use disorders in the region.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Review
Oncology
Neda Orouji, Siamak Kazemi Asl, Zahra Taghipour, Solomon Habtemariam, Seyed Mohammad Nabavi, Roja Rahimi
Summary: Glucosinolates, found in Brassicaceae family, can be hydrolyzed into isothiocyanates which have anti-cancer effects. Glucosinolate metabolites exert their cancer-preventive activity through various mechanisms and can also be effective in cancer treatment. However, some isothiocyanates may increase the risk of tumors, thus further studies are needed to determine the appropriate dosage for different types of tumors.
Article
Chemistry, Applied
Maryam Keykhaee, Mahban Rahimifard, Alireza Najafi, Maryam Baeeri, Mohammad Abdollahi, Fatemeh Mottaghitalab, Mehdi Farokhi, Mehdi Khoobi
Summary: The study proposes a novel approach using a multifunctional hydrogel to manage diabetic foot ulcers (DFUs). The hydrogel, made from a combination of alginate and gum arabic, is enhanced with nerve growth factor (NGF) immobilized in specially designed mesoporous silica nanoparticles (MSN). The hydrogel shows sustained release of NGF and significantly improves wound healing. The hydrogel also reduces inflammation, increases angiogenesis, and improves tissue pathology. This newly developed composite system holds promise as a potential treatment for non-healing diabetic wounds.
CARBOHYDRATE POLYMERS
(2023)
