Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines
出版年份 2019 全文链接
标题
Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines
作者
关键词
-
出版物
Cancers
Volume 11, Issue 1, Pages 92
出版商
MDPI AG
发表日期
2019-01-16
DOI
10.3390/cancers11010092
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy
- (2018) Guan-Jun Yang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Identification of a rhodium(iii) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells
- (2018) Guan-Jun Yang et al. CHEMICAL COMMUNICATIONS
- Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins
- (2018) Abbas H. K. Al Temimi et al. CHEMICAL COMMUNICATIONS
- KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer
- (2018) Besa Xhabija et al. SEMINARS IN CANCER BIOLOGY
- Role of RBP2-Induced ER and IGF1R-ErbB Signaling in Tamoxifen Resistance in Breast Cancer
- (2017) Hee-Joo Choi et al. JNCI-Journal of the National Cancer Institute
- Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury
- (2017) Yi Kuang et al. PHYTOMEDICINE
- Licoricidin inhibits the growth of SW480 human colorectal adenocarcinoma cells in vitro and in vivo by inducing cycle arrest, apoptosis and autophagy
- (2017) Shuai Ji et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
- (2017) John D. Chan et al. Nature Communications
- Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells
- (2017) Barbara Banelli et al. Oncotarget
- Role of RBP2-Induced ER and IGF1R-ErbB Signaling in Tamoxifen Resistance in Breast Cancer
- (2017) Hee-Joo Choi et al. JNCI-Journal of the National Cancer Institute
- Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication
- (2017) Ying Wang et al. Scientific Reports
- Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies
- (2016) Jun Liang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction
- (2016) Hai-Jing Zhong et al. CHEMICAL COMMUNICATIONS
- 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors
- (2016) Vassilios Bavetsias et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis
- (2016) Vassilios Myrianthopoulos et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural analysis of human KDM5B guides histone demethylase inhibitor development
- (2016) Catrine Johansson et al. Nature Chemical Biology
- An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells
- (2016) Maia Vinogradova et al. Nature Chemical Biology
- Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease
- (2016) Giampaolo Bianchini et al. Nature Reviews Clinical Oncology
- Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance
- (2016) Molly Gale et al. Oncotarget
- Anticancer Gold(III) Porphyrins Target Mitochondrial Chaperone Hsp60
- (2015) Di Hu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice
- (2015) M. H. Stewart et al. BLOOD
- Advances in the development of histone lysine demethylase inhibitors
- (2015) Tamara Maes et al. CURRENT OPINION IN PHARMACOLOGY
- Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases
- (2015) John R. Horton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors
- (2015) Magdalena Korczynska et al. JOURNAL OF MEDICINAL CHEMISTRY
- An Iridium(III) Complex Inhibits JMJD2 Activities and Acts as a Potential Epigenetic Modulator
- (2015) Li-Juan Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Virtual screening in small molecule discovery for epigenetic targets
- (2015) Guo-Bo Li et al. METHODS
- Targeting histone lysine methylation in cancer
- (2015) John McGrath et al. PHARMACOLOGY & THERAPEUTICS
- An iridium(iii)-based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent
- (2015) Hai-Jing Zhong et al. Chemical Science
- Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders
- (2015) Christina N Vallianatos et al. Epigenomics
- Targeting histone lysine demethylases — Progress, challenges, and the future
- (2014) Cyrille C. Thinnes et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- An Unbiased Method To Build Benchmarking Sets for Ligand-Based Virtual Screening and its Application To GPCRs
- (2014) Jie Xia et al. Journal of Chemical Information and Modeling
- Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis
- (2014) Lupeng Li et al. Molecular Cancer
- Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening
- (2014) L-J Liu et al. Cell Death & Disease
- Histone Demethylase RBP2 Is Critical for Breast Cancer Progression and Metastasis
- (2014) Jian Cao et al. Cell Reports
- Structure–activity relationship studies of thalidomide analogs with a taxol-like mode of action
- (2013) Bulbul Pandit et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis
- (2013) Y.-C. Teng et al. CANCER RESEARCH
- Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
- (2013) D. M. Molina et al. SCIENCE
- Histone lysine demethylases in breast cancer
- (2012) Elisa Paolicchi et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Mechanisms of human histone and nucleic acid demethylases
- (2012) Louise J Walport et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Docking and scoring with ICM: the benchmarking results and strategies for improvement
- (2012) Marco A. C. Neves et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Herb–drug pharmacokinetic interaction between radix astragali and pioglitazone in rats
- (2012) Yue-mei Yuan et al. JOURNAL OF ETHNOPHARMACOLOGY
- Quantifying four-probe metabolites in a single UPLC–MS/MS run to explore the effects of cooked rhubarb on cytochrome P450 isozymes
- (2012) Meicun Yao et al. Bioanalysis
- Computational chemistry in 25 years
- (2011) Ruben Abagyan JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer
- (2011) Lauren P. Blair et al. Cancers
- The Histone Demethylase RBP2 Is Overexpressed in Gastric Cancer and Its Inhibition Triggers Senescence of Cancer Cells
- (2009) Jiping Zeng et al. GASTROENTEROLOGY
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