Editorial Material
Chemistry, Multidisciplinary
Alexandre de Nonneville, Pascal Finetti, Daniel Birnbaum, Emilie Mamessier, Francois Bertucci
Summary: This study demonstrates the critical role of WEE1 in triple negative breast cancer, its pejorative prognostic value, and its correlation with biomarkers of sensitivity to WEE1 inhibitors.
Article
Chemistry, Medicinal
Carine M. Abdelmalek, Zexi Hu, Thales Kronenberger, Jenni Kublbeck, Franziska J. M. Kinnen, Salma S. Hesse, Afsin Malik, Mark Kudolo, Raimund Niess, Matthias Gehringer, Lars Zender, Paula A. Witt-Enderby, Darius P. Zlotos, Stefan A. Laufer
Summary: Anticancer drug conjugates that simultaneously target two receptors may overcome the limitations of current cancer treatments. A series of compounds connecting tamoxifen or endoxifen with the EGFR-inhibitor gefitinib exhibit potent anticancer activity in breast cancer cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Zahi Mitri, Nour Abuhadra, Shaun M. Goodyear, Evthokia A. Hobbs, Andy Kaempf, Alastair M. Thompson, Stacy L. Moulder
Summary: By applying an Evolutionary Action Score (EAp53) to functionally characterize TP53 mutations in TNBC patients, this study found that EAp53 stratification may identify TP53 mutations associated with worse outcomes, indicating potential for enhanced clinical management.
NPJ PRECISION ONCOLOGY
(2022)
Article
Oncology
Alaa Embaby, Joachim Kutzera, Jill J. Geenen, Dick Pluim, Ingrid Hofland, Joyce Sanders, Marta Lopez-Yurda, Jos H. Beijnen, Alwin D. R. Huitema, Petronella O. Witteveen, Neeltje Steeghs, Gijs van Haaften, Marcel A. T. M. van Vugt, Jeroen de Ridder, Frans L. Opdam
Summary: This study investigates the safety and efficacy of the combination of carboplatin and adavosertib in treating TP53 mutated platinum-resistant ovarian cancer, and explores predictive biomarkers for resistance and response. The results show that the combination treatment is safe and has anti-tumor efficacy in patients, but bone marrow toxicity remains a concern.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Elzbieta Senkus, Suzette Delaloge, Susan M. Domchek, Pierfranco Conte, Seock-Ah Im, Binghe Xu, Anne Armstrong, Norikazu Masuda, Anitra Fielding, Mark Robson, Nadine Tung
Summary: In the primary analysis of the phase III OlympiAD trial, olaparib significantly extended the progression-free survival in patients with germline BRCA-mutated, HER2-negative metastatic breast cancer compared to chemotherapy treatment. Subgroup analyses confirmed the consistent benefit of olaparib across various patient subgroups.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Kun Sun, Hong Zhu, Weimin Chai, Fuhua Yan
Summary: The study aimed to explore the value of T1WI, T2WI, and DWI radiomics features in reflecting TP53 mutations in TNBC. A retrospective study enrolled 91 TNBC patients with TP53 testing. Multiple classification models were used for classification, and the SVM model showed the highest AUC (0.85) and diagnostic accuracy (0.82). The findings recommend the use of radiomics-based analysis with the SVM model for the detection of TP53 mutations in TNBC, and T1WI and T2WI-related features as noninvasive biomarkers for predicting TP53 mutations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Riley Plett, Paul Mellor, Stephanie Kendall, S. Austin Hammond, Aren Boulet, Kristine Plaza, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Deborah H. Anderson
Summary: The lack of targeted therapies for triple-negative breast cancer (TNBC) leads to higher mortality rates and risk of relapse compared to other breast cancer subtypes. In this study, researchers screened an FDA-approved drug library and identified four drugs that were highly cytotoxic towards TNBC cells with CREB3L1 deficiency. Homoharringtonine showed the most significant cytotoxicity and synergistic effect when combined with paclitaxel, suggesting its potential for TNBC treatment.
SCIENTIFIC REPORTS
(2022)
Review
Nanoscience & Nanotechnology
Siyan Liu, Jing Li, Lin Gu, Kunzhe Wu, Hua Xing
Summary: Chemoimmunotherapy shows promise for treating TNBC, but challenges remain in improving efficacy and reducing side effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Fabienne Lamballe, Fahmida Ahmad, Yaron Vinik, Olivier Castellanet, Fabrice Daian, Anna-Katharina Muller, Ulrike A. Kohler, Anne-Laure Bailly, Emmanuelle Josselin, Remy Castellano, Christelle Cayrou, Emmanuelle Charafe-Jauffret, Gordon B. Mills, Vincent Geli, Jean-Paul Borg, Sima Lev, Flavio Maina
Summary: A unique mouse model of TNBC has been developed, faithfully recapitulating the intertumoral heterogeneity of human TNBC tumors. Targeting both WEE1 and BCL-XL synergistically kills TNBC cells and efficiently induces tumor regression, providing potential therapeutic targets for TNBC treatment.
Article
Dentistry, Oral Surgery & Medicine
Aisha Hussein Al-Jamaei, Jan G. A. M. de Visscher, V. Ramadugula Subramanyam, Tymour Forouzanfar, Peter Sminia, Behrouz Zandieh Doulabi, Marco N. Helder
Summary: This study investigated the effectiveness of WEE1 kinase inhibitor (MK-1775) in enhancing radiation responses of OTSCC cells in vitro. The results showed that MK-1775 inhibited the survival of OTSCC cells and enhanced their response to radiation by inducing apoptosis and lethal mitosis. This demonstrates the potential of WEE1 inhibitor as a potent radiosensitizer in OTSCC.
Article
Pharmacology & Pharmacy
Sha-Sha Cheng, Yuan-Qing Qu, Jia Wu, Guan-Jun Yang, Hao Liu, Wanhe Wang, Qi Huang, Feng Chen, Guodong Li, Chun-Yuen Wong, Vincent Kam Wai Wong, Dik-Lung Ma, Chung-Hang Leung
Summary: CDK9 inhibition is a potential therapeutic strategy for TNBC, and compound 1 demonstrates promising anti-metastatic activity.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Lake-Ee Quek, Michelle van Geldermalsen, Yi Fang Guan, Kanu Wahi, Chelsea Mayoh, Seher Balaban, Angel Pang, Qian Wang, Mark J. Cowley, Kristin K. Brown, Nigel Turner, Andrew J. Hoy, Jeff Holst
Summary: This study reveals that glutamine-indispensable triple-negative breast cancer (TNBC) cells rely on a non-canonical glutamine-to-glutamate overflow, which increases TCA cycle fluxes and replenishes TCA cycle intermediates. The coupling of glucose and glutamine catabolism hampers TNBC cells' ability to oxidize glucose when glutamine is limiting.
Article
Genetics & Heredity
Justine Marsolier, Pacome Prompsy, Adeline Durand, Anne-Marie Lyne, Camille Landragin, Amandine Trouchet, Sabrina Tenreira Bento, Almut Eisele, Sophie Foulon, Lea Baudre, Kevin Grosselin, Mylene Bohec, Sylvain Baulande, Ahmed Dahmani, Laura Sourd, Eric Letouze, Anne-Vincent Salomon, Elisabetta Marangoni, Leila Perie, Celine Vallot
Summary: The persistence of drug-resistant cancer cells is a major clinical challenge, particularly in triple-negative breast cancer. This study reveals that the repressive histone mark H3K27me3 plays a crucial role in regulating cell fate and chemotherapy tolerance in cancer cells. Manipulating H3K27me3 levels effectively enhances the potential of cancer cells to tolerate chemotherapy and delays tumor recurrence. These findings underscore the importance of understanding chromatin landscapes in shaping cancer cell response to initial therapy.
Article
Oncology
Jingyu Peng, Ming Yang, Ran Bi, Yueyuan Wang, Chunxi Wang, Xue Wei, Zhihao Zhang, Xiao Xie, Wei Wei
Summary: The study found that CDK7 inhibitors are more effective in TNBC cells with p53 mutations, with the treatment specifically downregulating mutated p53 expression and suppressing cell proliferation. Targeting CDK7 could be an effective approach for treating TNBC with p53 mutation.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Dorota Kwapisz
Summary: Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and limited treatment options, but it shows higher immunogenicity, tumor-infiltrating lymphocytes (TILs) enrichment, and programmed cell death ligand 1 (PD-L1) expression which make it more suitable for immune checkpoint blockade therapy. Patients with PD-L1-positive TNBC subgroup may benefit the most from immune checkpoint inhibitor (ICI) treatment, and ICI given as first-line treatment in advanced TNBC shows better results than in later lines of treatment. Exciting results have been seen with pembrolizumab in early-stage TNBC, indicating potential approval in (neo)adjuvant settings in the near future.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Lin-Lin Feng, You-Wu Dai, Xin-Jiang Lu, Jian-Fei Lu, Guan-Jun Yang, Hao Zhang, Li Zhang, Jiong Chen
Summary: This study discovered two isoforms of ACTH in the immune system of ayu, a type of fish. The two isoforms, PaACTH-A and PaACTH-B, have different immune functions. PaACTH-A shows anti-inflammatory effects and PaACTH-B enhances the bactericidal capacity of macrophages.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sha-Sha Cheng, Yuan-Qing Qu, Jia Wu, Guan-Jun Yang, Hao Liu, Wanhe Wang, Qi Huang, Feng Chen, Guodong Li, Chun-Yuen Wong, Vincent Kam Wai Wong, Dik-Lung Ma, Chung-Hang Leung
Summary: CDK9 inhibition is a potential therapeutic strategy for TNBC, and compound 1 demonstrates promising anti-metastatic activity.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Fisheries
Si-Ying Chen, Xiao-Lin Zhan, Rui Jiang, You-Wu Dai, Jian-Fei Lu, Guan-Jun Yang, Jiong Chen, Xin-Jiang Lu
Summary: This study identified the cDNA sequence of MMP25 in Japanese sea bass and revealed its role in regulating inflammatory responses. LjMMP25 was found to regulate inflammatory cytokine production and promote phagocytosis and bacterial killing in monocytes/macrophages. LjMMP25 also modulated the inflammatory response by regulating NF-kappa B signaling.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Lin Zhan, Si-Ying Chen, Rui Jiang, You-Wu Dai, Jian-Fei Lu, Guan-Jun Yang, Jiong Chen, Xin-Jiang Lu
Summary: This study reveals that LjCXCR4a and LjCXCR4b modulate the immune response of Japanese sea bass B cells against bacterial infection, albeit via different pathways.
MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Chao Yang, Dan Li, Dehong Teng, Yueru Zhou, Lei Zhang, Zhangfeng Zhong, Guan-Jun Yang
Summary: This review discusses the research on the pathogenesis of rheumatoid arthritis (RA) in the past five years based on epigenetic modifications, providing new methods and strategies for the diagnosis and treatment of this disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Li-Juan Chen, Xin-Yang Xu, Xiao-Dan Zhong, Yan-Jun Liu, Ming-Hui Zhu, Fan Tao, Chang-Yun Li, Qiu-Sheng She, Guan-Jun Yang, Jiong Chen
Summary: Histone demethylation is an important post-translational modification of chromatin, and its dysregulation affects various nuclear activities. KDM6A is a key enzyme involved in histone demethylation, and it plays a significant role in the development of multiple human diseases, particularly cancer. Inhibiting KDM6A has shown effectiveness in treating KDM6A-amplified cancers.
BIOORGANIC CHEMISTRY
(2023)
Article
Immunology
Licong Wang, Maoxia Yang, Sheng Luo, Guanjun Yang, Xinjiang Lu, Jianfei Lu, Jiong Chen
Summary: This study evaluated the protective efficacy of oral administration of surface-displayed ORF132 against CyHV-2 infection. The results showed that oral vaccination evoked strong immune responses and provided significant protection for crucian carp, resulting in a relative percent survival of 64%.
Article
Chemistry, Medicinal
Shasha Cheng, Yi Kuang, Guodong Li, Jia Wu, Chung-Nga Ko, Wanhe Wang, Dik-Lung Ma, Min Ye, Chung-Hang Leung
Summary: This study reports the use of dehydroeburicoic acid (DEA) as a dual inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) and GSK3 beta, providing potential therapeutic strategies for alcoholic liver disease (ALD). DEA disrupts the Keap1-Nrf2 PPI and restores Nrf2 activity, leading to the activation of antioxidant genes. It also alleviates ethanol-induced mitochondrial dysfunction and exhibits minimal toxicity in the ALD cell model.
Article
Biology
Zizhen Si, GuanJun Yang, Xidi Wang, Zhaoying Yu, Qian Pang, Shuangshuang Zhang, Liyin Qian, Yuer Ruan, Jing Huang, Liu Yu
Summary: In the past decade, the use of METH has doubled, indicating that it could become the next global substance use crisis. METH causes harmful inflammatory responses, oxidative stress, and DNA damage, which are driving factors for hepatocellular carcinoma (HCC). However, the role of METH in HCC and the underlying mechanisms are still unknown.
LIFE SCIENCE ALLIANCE
(2023)
Review
Chemistry, Inorganic & Nuclear
Wanhe Wang, Jianhua Liu, Sang-Cuo Nao, Dik-Lung Ma, Jing Wang, Chung-Hang Leung
Summary: Changes in protein levels and types can indicate the occurrence of diseases, making differentially expressed proteins useful biomarkers for diagnosis and treatment. Luminescent iridium(III) complexes, especially affinity-based ones, with excellent optical properties, have gained attention in protein-based disease diagnostics. This review summarizes the current advances and future perspectives of affinity-based luminescent iridium(III) complexes for detecting disease-related proteins.
Review
Chemistry, Medicinal
Ying-Qi Song, Guan-Jun Yang, Dik-Lung Ma, Wanhe Wang, Chung-Hang Leung
Summary: Histone methylation is involved in regulating gene expression and maintaining genome integrity and epigenetic inheritance. Abnormalities in histone methylation are commonly observed in human diseases, especially cancer. Lysine demethylases (KDMs) can reverse lysine methylation mediated by histone methyltransferases. KDMs play a role in drug resistance by altering the metabolic profile of cancer cells, upregulating cancer stem cells and drug-tolerant genes, and promoting the epithelial-mesenchymal transition and metastatic ability. This review discusses the structural features and functions of KDMs, their preferences in different cancers, and the mechanisms of drug resistance resulting from KDMs. It also explores KDM inhibitors used to combat drug resistance in cancer and the opportunities and challenges of targeting KDMs for cancer therapy.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Immunology
Ming-Hui Zhu, Yan-Jun Liu, Chang-Yun Li, Fan Tao, Guan-Jun Yang, Jiong Chen
Summary: Leukocyte cell-derived chemotaxin-2 (LECT2) is a multifunctional secreted factor involved in various physiological and pathological processes, including immune processes and immune-related diseases. It interacts with cell surface receptors such as CD209a, Tie1, and Met, and can lead to amyloidosis in important tissues. The mechanisms of LECT2-mediated immune pathogenic conditions in different tissues are still not fully understood due to functional and signaling heterogeneity. This review provides a comprehensive understanding of LECT2's structure, function, signaling pathways, and potential applications in theranostics of immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Chang-Yun Li, Yan-Jun Liu, Fan Tao, Ru-Yi Chen, Jin-Jin Shi, Jian-Fei Lu, Guan -Jun Yang, Jiong Chen
Summary: This article discusses the important role of lysine-specific demethylase 7A (KDM7A) in biological regulation and disease development, as well as its structure, function, and potential drug treatments. KDM7A is not only crucial for normal development but also associated with various diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Editorial Material
Immunology
Yan-Jun Liu, Hai-Jing Zhong, Haitao Wang, Cheong-Meng Chong, Guan-Jun Yang
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Hai-Jing Zhong, Wanhe Wang, Wei Zhou, Jia-Xin Liang, Yung-Chi Cheng, Dik-Lung Ma, Chung-Hang Leung
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
