Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6

Intake of dairy foods and risk of Parkinson disease

(2017) Katherine C. Hughes et al.   NEUROLOGY

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity

(2017) Rafael M. Ioris et al.   Cell Reports

Neuroprotective Functions for the Histone Deacetylase SIRT6

(2017) Shai Kaluski et al.   Cell Reports

Inflammatory Process in Alzheimer's and Parkinson's Diseases: Central Role of Cytokines

(2016) Qamre Alam et al.   CURRENT PHARMACEUTICAL DESIGN

Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration

(2016) Lijuan Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons

(2016) R. Srinivasan et al.   JOURNAL OF NEUROSCIENCE

The epidemiology of Parkinson's disease: risk factors and prevention

(2016) Alberto Ascherio et al.   LANCET NEUROLOGY

Elevated mitochondria-coupled NAD(P)H in endoplasmic reticulum of dopamine neurons

(2016) Kristal R. Tucker et al.   MOLECULAR BIOLOGY OF THE CELL

Lysine fatty acylation promotes lysosomal targeting of TNF-α

(2016) Hong Jiang et al.   Scientific Reports

Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage

(2016) Jiaxiang Shao et al.   Protein & Cell

p53-dependent SIRT6 expression protects Aβ42-induced DNA damage

(2016) Eun Sun Jung et al.   Scientific Reports

Lifestyle, Family History, and Risk of Idiopathic Parkinson Disease: A Large Danish Case-Control Study

(2015) Line Kenborg et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Association between cigarette smoking and Parkinson’s disease: A meta-analysis

(2015) Xiao Li et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Parkinson's disease research in a prospective cohort in China

(2015) Honglei Chen et al.   PARKINSONISM & RELATED DISORDERS

Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair

(2015) Shrestha Ghosh et al.   Cell Reports

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Mendelian genes for Parkinson's disease contribute to the sporadic forms of the disease†

(2014) Nino Spataro et al.   HUMAN MOLECULAR GENETICS

Discovery of Novel and Selective SIRT6 Inhibitors

(2014) Marco Daniele Parenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biochemical Characterization of Sirtuin 6 in the Brain and Its Involvement in Oxidative Stress Response

(2014) Alessio Cardinale et al.   NEUROCHEMICAL RESEARCH

Parkinson disease and smoking revisited: Ease of quitting is an early sign of the disease

(2014) B. Ritz et al.   NEUROLOGY

Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors

(2014) Bin He et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer

(2014) U. Thirumurthi et al.   Science Signaling

Differential expression of sirtuin family members in the developing, adult, and aged rat brain

(2014) Elena Sidorova-Darmos et al.   Frontiers in Aging Neuroscience

Transcriptional regulation by nicotine in dopaminergic neurons

(2013) Beverley M. Henley et al.   BIOCHEMICAL PHARMACOLOGY

Sirtuin deacetylases in neurodegenerative diseases of aging

(2013) Adrianna Z Herskovits et al.   CELL RESEARCH

Overview and Findings from the Religious Orders Study

(2013) David A. Bennett et al.   Current Alzheimer Research

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence

(2013) N. Takasaka et al.   JOURNAL OF IMMUNOLOGY

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

Programmed Cell Death in Parkinson's Disease

(2013) K. Venderova et al.   Cold Spring Harbor Perspectives in Medicine

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

Involvement of monoamine oxidase-B in the acute neurotoxicity of MPTP in embryonic and newborn mice

(2012) Takafumi Sai et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+Responses

(2012) Inga Bauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

(2012) Nagalingam R Sundaresan et al.   NATURE MEDICINE

Meta-analysis of Parkinson's Disease: Identification of a novel locus, RIT2

(2011) Nathan Pankratz et al.   ANNALS OF NEUROLOGY

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

(2011) Michael Van Meter et al.   CELL CYCLE

Akt as a Victim, Villain and Potential Hero in Parkinson’s Disease Pathophysiology and Treatment

(2011) Lloyd A. Greene et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Environmental tobacco smoke and Parkinson's disease

(2011) Susan Searles Nielsen et al.   MOVEMENT DISORDERS

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Can nicotine be used medicinally in Parkinson’s disease?

(2011) Claire Thiriez et al.   Expert Review of Clinical Pharmacology

Active and passive smoking and risk of Parkinson’s disease

(2010) K. Tanaka et al.   ACTA NEUROLOGICA SCANDINAVICA

SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus

(2010) A. Satoh et al.   JOURNAL OF NEUROSCIENCE

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

Smoking duration, intensity, and risk of Parkinson disease

(2010) H. Chen et al.   NEUROLOGY

Neuronal nicotinic receptors as novel targets for inflammation and neuroprotection: mechanistic considerations and clinical relevance

(2009) Merouane Bencherif   ACTA PHARMACOLOGICA SINICA

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

(2009) Frédéric Van Gool et al.   NATURE MEDICINE

Incidence and remaining lifetime risk of Parkinson disease in advanced age

(2009) J. A. Driver et al.   NEUROLOGY

Akt signal transduction dysfunction in Parkinson's disease

(2009) Suzanne Timmons et al.   NEUROSCIENCE LETTERS

Optimal Serum Cotinine Levels for Distinguishing Cigarette Smokers and Nonsmokers Within Different Racial/Ethnic Groups in the United States Between 1999 and 2004

(2008) Neal L. Benowitz et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Regulation of SIRT6 protein levels by nutrient availability

(2008) Yariv Kanfi et al.   FEBS LETTERS

Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

(2008) Jason A. Pfister et al.   PLoS One

Aβ1–42 modulation of Akt phosphorylation via α7 nAChR and NMDA receptors

(2007) Jonathan J. Abbott et al.   NEUROBIOLOGY OF AGING