Hantavirus-Driven PD-L1/PD-L2 Upregulation: An Imperfect Viral Immune Evasion Mechanism

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8 + T Cells

(2018) Jing Li et al.   IMMUNITY

Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations

(2018) Ioannis Zerdes et al.   ONCOGENE

Role of PD-1 during effector CD8 T cell differentiation

(2018) Eunseon Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells

(2018) Tomas Strandin et al.   Frontiers in Immunology

Massive plasmablast response elicited in the acute phase of hantavirus pulmonary syndrome

(2017) Marina García et al.   IMMUNOLOGY

Innate immune recognition of double-stranded RNA triggers increased expression of NKG2D ligands after virus infection

(2017) Gloria Esteso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The immunoinhibitory PD-1/PD-L1 pathway in inflammatory blood vessel disease

(2017) Cornelia M. Weyand et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The nucleocapsid protein of hantaviruses: much more than a genome-wrapping protein

(2017) Monika Reuter et al.   VIRUS GENES

Kaposi’s Sarcoma-Associated Herpesvirus Increases PD-L1 and Proinflammatory Cytokine Expression in Human Monocytes

(2017) Kurtis M. Host et al.   mBio

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways

(2017) Saskia Scholz et al.   PLoS Pathogens

Outrunning the Red Queen: bystander activation as a means of outpacing innate immune subversion by intracellular pathogens

(2016) Alicia M Holmgren et al.   Cellular & Molecular Immunology

Cytotoxic immune responses in the lungs correlate to disease severity in patients with hantavirus infection

(2016) J. Rasmuson et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

CD28 Costimulation: From Mechanism to Therapy

(2016) Jonathan H. Esensten et al.   IMMUNITY

Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease

(2016) John Attanasio et al.   IMMUNITY

Memory CD8 + T Cells: Innate-Like Sensors and Orchestrators of Protection

(2016) Grégoire Lauvau et al.   TRENDS IN IMMUNOLOGY

CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection

(2016) Namir Shaabani et al.   Cell Death & Disease

Viral Manipulation of Host Inhibitory Receptor Signaling for Immune Evasion

(2016) Eugenia Z. Ong et al.   PLoS Pathogens

Memory CD8+ T Cells: Orchestrators and Key Players of Innate Immunity?

(2016) Grégoire Lauvau et al.   PLoS Pathogens

TLR3 triggering regulates PD-L1 (CD274) expression in human neuroblastoma cells

(2015) Marianne Boes et al.   CANCER LETTERS

CD14+ cells from peripheral blood positively regulate hematopoietic stem and progenitor cell survival resulting in increased erythroid yield

(2015) E. Heideveld et al.   HAEMATOLOGICA

Hantaviruses—Globally emerging pathogens

(2015) Detlev H. Kruger et al.   JOURNAL OF CLINICAL VIROLOGY

Hantavirus-induced pathogenesis in mice with a humanized immune system

(2015) Lidija Kobak et al.   JOURNAL OF GENERAL VIROLOGY

CD8lowCD100−T Cells Identify a Novel CD8 T Cell Subset Associated with Viral Control during Human Hantaan Virus Infection

(2015) Bei Liu et al.   JOURNAL OF VIROLOGY

PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing

(2015) Ilseyar Akhmetzyanova et al.   PLoS Pathogens

Hantavirus-induced disruption of the endothelial barrier: neutrophils are on the payroll

(2015) Günther Schönrich et al.   Frontiers in Microbiology

CD14+ cells from peripheral blood positively regulate hematopoietic stem and progenitor cell survival resulting in increased erythroid yield

(2015) E. Heideveld et al.   HAEMATOLOGICA

Viral Infection of Human Lung Macrophages Increases PDL1 Expression via IFNβ

(2015) Karl J. Staples et al.   PLoS One

Upregulation of IFN-γ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome

(2014) S. F. Khaiboullina et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Japanese encephalitis virus expands regulatory T cells by increasing the expression of PD-L1 on dendritic cells

(2014) Nimesh Gupta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Memory-T-Cell-Derived Interferon-γ Instructs Potent Innate Cell Activation for Protective Immunity

(2014) Saïdi M’Homa Soudja et al.   IMMUNITY

β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps

(2014) Martin J. Raftery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIV-1 Tat Protein Induces PD-L1 (B7-H1) Expression on Dendritic Cells through Tumor Necrosis Factor Alpha- and Toll-Like Receptor 4-Mediated Mechanisms

(2014) R. Planes et al.   JOURNAL OF VIROLOGY

Hantaan Virus Infection Induces CXCL10 Expression through TLR3, RIG-I, and MDA-5 Pathways Correlated with the Disease Severity

(2014) Yusi Zhang et al.   MEDIATORS OF INFLAMMATION

NK Cell Activation in Human Hantavirus Infection Explained by Virus-Induced IL-15/IL15Rα Expression

(2014) Monika Braun et al.   PLoS Pathogens

The fundamental role of endothelial cells in hantavirus pathogenesis

(2014) Jussi Hepojoki et al.   Frontiers in Microbiology

Influenza infection results in local expansion of memory CD8+T cells with antigen non-specific phenotype and function

(2013) Gail D. Sckisel et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Hantaviral mechanisms driving HLA class I antigen presentation require both RIG-I and TRIF

(2013) Pritesh Lalwani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cell response correlates with the severity of human hantavirus infection

(2013) Tuisku-Tuulia Koivula et al.   JOURNAL OF INFECTION

Uncovering the mysteries of hantavirus infections

(2013) Antti Vaheri et al.   NATURE REVIEWS MICROBIOLOGY

Bystander-Activated Memory CD8 T Cells Control Early Pathogen Load in an Innate-like, NKG2D-Dependent Manner

(2013) Talyn Chu et al.   Cell Reports

Hantavirus-infection Confers Resistance to Cytotoxic Lymphocyte-Mediated Apoptosis

(2013) Shawon Gupta et al.   PLoS Pathogens

Pathogenesis of the Viral Hemorrhagic Fevers

(2012) Slobodan Paessler et al.   Annual Review of Pathology-Mechanisms of Disease

PD-L1-Expressing Dendritic Cells Contribute to Viral Resistance during Acute HSV-1 Infection

(2012) Katie M. Bryant-Hudson et al.   Clinical & Developmental Immunology

Viral acute lower respiratory infections impair CD8+ T cells through PD-1

(2012) John J. Erickson et al.   JOURNAL OF CLINICAL INVESTIGATION

Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice

(2012) Helge Frebel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Seoul Virus-Infected Rat Lung Endothelial Cells and Alveolar Macrophages Differ in Their Ability To Support Virus Replication and Induce Regulatory T Cell Phenotypes

(2012) W. Li et al.   JOURNAL OF VIROLOGY

Regulation of innate CD8+ T-cell activation mediated by cytokines

(2012) B. E. Freeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Soluble Form of B7-H1 That Retains Immunosuppressive Activity and Is Associated with Aggressive Renal Cell Carcinoma

(2011) X. Frigola et al.   CLINICAL CANCER RESEARCH

Development of a sandwich ELISA for evaluating soluble PD-L1 (CD274) in human sera of different ages as well as supernatants of PD-L1+ cell lines

(2011) Yongjing Chen et al.   CYTOKINE

Soluble B7-H1: Differences in production between dendritic cells and T cells

(2011) Xavier Frigola et al.   IMMUNOLOGY LETTERS

The PD-1/PD-L1 (B7-H1) Pathway in Chronic Infection-Induced Cytotoxic T Lymphocyte Exhaustion

(2011) Kimberly A. Hofmeyer et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

RNA helicase retinoic acid-inducible gene I as a sensor of Hantaan virus replication

(2011) M.-H. Lee et al.   JOURNAL OF GENERAL VIROLOGY

Virus-Specific CD8+ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus Replication

(2011) G. Zelinskyy et al.   JOURNAL OF IMMUNOLOGY

Longitudinal Analysis of the Human T Cell Response during Acute Hantavirus Infection

(2011) T. Lindgren et al.   JOURNAL OF VIROLOGY

Unexpected protective role for Toll-like receptor 3 in the arterial wall

(2011) J. E. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infection of human monocyte-derived dendritic cells by ANDES Hantavirus enhances pro-inflammatory state, the secretion of active MMP-9 and indirectly enhances endothelial permeability

(2011) Delphine Marsac et al.   Virology Journal

T Cells and Pathogenesis of Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever with Renal Syndrome

(2011) Masanori Terajima et al.   Viruses-Basel

Bystander T cells in human immune responses to dengue antigens

(2010) Duangchan Suwannasaen et al.   BMC IMMUNOLOGY

Role of PD-1 in regulating acute infections

(2010) Keturah E Brown et al.   CURRENT OPINION IN IMMUNOLOGY

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus

(2010) Niklas K. Björkström et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10

(2010) M. Rodriguez-Garcia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

Contribution of Herpesvirus Specific CD8 T Cells to Anti-Viral T Cell Response in Humans

(2010) Elena Sandalova et al.   PLoS Pathogens

Hepatitis C Virus Core Protein Subverts the Antiviral Activities of Human Kupffer Cells

(2009) Zhengkun Tu et al.   GASTROENTEROLOGY

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hantaan Virus Triggers TLR3-Dependent Innate Immune Responses

(2009) W. Handke et al.   JOURNAL OF IMMUNOLOGY

TLR3-Stimulated Dendritic Cells Up-regulate B7-H1 Expression and Influence the Magnitude of CD8 T Cell Responses to Tumor Vaccination

(2009) V. Pulko et al.   JOURNAL OF IMMUNOLOGY

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Hantavirus-induced immunity in rodent reservoirs and humans

(2008) Günther Schönrich et al.   IMMUNOLOGICAL REVIEWS