Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice

Detrimental Contribution of the Immuno-Inhibitor B7-H1 to Rabies Virus Encephalitis

(2014) M. Lafon et al.   JOURNAL OF IMMUNOLOGY

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment

(2011) Michael A. Matthay et al.   Annual Review of Pathology-Mechanisms of Disease

Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms

(2011) Mikayel Mkrtichyan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade

(2011) R. Bhadra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broken Barriers: A New Take on Sepsis Pathogenesis

(2011) N. M. Goldenberg et al.   Science Translational Medicine

Pathogenesis of lassa fever in cynomolgus macaques

(2011) Lisa E Hensley et al.   Virology Journal

Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) Infection

(2011) Yongwen Chen et al.   PLoS Pathogens

Role of PD-1 in regulating acute infections

(2010) Keturah E Brown et al.   CURRENT OPINION IN IMMUNOLOGY

B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis

(2010) Keith M. Hamel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IFN-γ-receptor signaling ameliorates transplant vasculopathy through attenuation of CD8+T-cell-mediated injury of vascular endothelial cells

(2010) Beatrice Bolinger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Translating insights from persistent LCMV infection into anti-HIV immunity

(2010) Elizabeth B. Wilson et al.   IMMUNOLOGIC RESEARCH

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

New therapy to revert dysfunctional antibody responses during HIV-1 infection

(2010) Francesca Chiodi   JOURNAL OF CLINICAL INVESTIGATION

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice

(2010) Scott N. Mueller et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

(2010) Julie R. Brahmer et al.   JOURNAL OF CLINICAL ONCOLOGY

Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation

(2010) Koichi Araki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhanced Antiviral T Cell Function in the Absence of B7-H1 Is Insufficient To Prevent Persistence but Exacerbates Axonal Bystander Damage during Viral Encephalomyelitis

(2010) T. W. Phares et al.   JOURNAL OF IMMUNOLOGY

CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1-Mediated Inhibition

(2010) D. L. Barber et al.   JOURNAL OF IMMUNOLOGY

RSV-Induced Bronchial Epithelial Cell PD-L1 Expression Inhibits CD8+ T Cell Nonspecific Antiviral Activity

(2010) Aurica G. Telcian et al.   JOURNAL OF INFECTIOUS DISEASES

Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis

(2010) E. Lazar-Molnar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Emerging Toxicity Profiles of Anti–CTLA-4 Antibodies Across Clinical Indications

(2010) Anna Maria Di Giacomo et al.   SEMINARS IN ONCOLOGY

T Cell-Dependence of Lassa Fever Pathogenesis

(2010) Lukas Flatz et al.   PLoS Pathogens

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Costimulatory and coinhibitory receptors in anti-tumor immunity

(2009) Gregory Driessens et al.   IMMUNOLOGICAL REVIEWS

Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion

(2009) C. M. Bucks et al.   JOURNAL OF IMMUNOLOGY

Tissue-Specific Differences in PD-1 and PD-L1 Expression during Chronic Viral Infection: Implications for CD8 T-Cell Exhaustion

(2009) S. D. Blackburn et al.   JOURNAL OF VIROLOGY

High antigen levels are the cause of T cell exhaustion during chronic viral infection

(2009) S. N. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

(2009) Nobuhiro Nakamoto et al.   PLoS Pathogens

Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection

(2008) Sang-Jun Ha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment

(2008) Simona Urbani et al.   JOURNAL OF HEPATOLOGY

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis

(2008) Jiyun V. Kim et al.   NATURE

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Selective expansion of a subset of exhausted CD8 T cells by  PD-L1 blockade

(2008) S. D. Blackburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA