Gastrodin Ameliorates Cognitive Dysfunction in Diabetes Rat Model via the Suppression of Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation

Diabetic dyslipidaemia is associated with alterations in eNOS, caveolin-1, and endothelial dysfunction in streptozotocin treated rats

(2018) Yousif A. Shamsaldeen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Gastrodin inhibits high glucose‑induced human retinal endothelial cell apoptosis by regulating the SIRT1/TLR4/NF‑κBp65 signaling pathway

(2018) Tong‑He Zhang et al.   Molecular Medicine Reports

NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo

(2018) Yingjie Qi et al.   NEUROBIOLOGY OF DISEASE

Diabetes pathogenic mechanisms and potential new therapies based upon a novel target called TXNIP

(2018) Lance Thielen et al.   Current Opinion in Endocrinology Diabetes and Obesity

Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2018) Yadong Zhai et al.   Oncotarget

A Review on Central Nervous System Effects of Gastrodin

(2018) Yuan Liu et al.   Frontiers in Pharmacology

Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis

(2018) Yachun Han et al.   Redox Biology

Evidence for Cortical Neuronal Loss in Male Type 2 Diabetic Goto-Kakizaki Rats

(2018) Shafaat Hussain et al.   JOURNAL OF ALZHEIMERS DISEASE

TRPM7 channels play a role in high glucose–induced endoplasmic reticulum stress and neuronal cell apoptosis

(2018) Yan Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

(2017) Emanuel Candeias et al.   MOLECULAR NEUROBIOLOGY

Endoplasmic reticulum stress and inflammation in the central nervous system

(2017) Neil T. Sprenkle et al.   Molecular Neurodegeneration

Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats

(2017) Xiaoxu Sun et al.   PHYSIOLOGY & BEHAVIOR

Berberine Ameliorates Diabetes-Associated Cognitive Decline through Modulation of Aberrant Inflammation Response and Insulin Signaling Pathway in DM Rats

(2017) Qingjie Chen et al.   Frontiers in Pharmacology

IL-1β Inhibition in Cardiovascular Complications Associated to Diabetes Mellitus

(2017) Concepción Peiró et al.   Frontiers in Pharmacology

The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise

(2016) Ming Cai et al.   BRAIN BEHAVIOR AND IMMUNITY

Insulin signalling in Alzheimer′s disease and diabetes: from epidemiology to molecular links

(2016) E. M. Ribe et al.   JOURNAL OF INTERNAL MEDICINE

Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease

(2016) J.-S. Zhang et al.   NEUROSCIENCE

Diabetes mellitus Type II and cognitive capacity in healthy aging, mild cognitive impairment and Alzheimer's disease

(2016) Christina Degen et al.   PSYCHIATRY RESEARCH

Anti-Diabetic Activities of Gastrodia elata Blume Water Extracts Are Mediated Mainly by Potentiating Glucose-Stimulated Insulin Secretion and Increasing β-Cell Mass in Non-Obese Type 2 Diabetic Animals

(2016) Hye Yang et al.   Nutrients

Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy

(2016) Zhouguang Wang et al.   Oncotarget

Activation of mTOR signaling mediates the increased expression of AChE in high glucose condition: in vitro and in vivo evidences

(2015) Yao-Wu Liu et al.   MOLECULAR NEUROBIOLOGY

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

(2015) G. Aleph Prieto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-amyloid, microglia, and the inflammasome in Alzheimer’s disease

(2015) Maike Gold et al.   Seminars in Immunopathology

Diabetes Mellitus, Cognitive Impairment, and Traditional Chinese Medicine

(2015) S. W. Seto et al.   International Journal of Endocrinology

Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions

(2014) Anusha Jayaraman et al.   Current Diabetes Reports

Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson's disease: Involvement of ERK1/2–Nrf2 signaling pathway

(2014) Xiao-Li Wang et al.   LIFE SCIENCES

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

(2013) Steven E Kahn et al.   LANCET

Endoplasmic reticulum dysfunction in neurological disease

(2012) Benoit D Roussel et al.   LANCET NEUROLOGY

Gastrodin Inhibits Allodynia and Hyperalgesia in Painful Diabetic Neuropathy Rats by Decreasing Excitability of Nociceptive Primary Sensory Neurons

(2012) Wei Sun et al.   PLoS One

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in diet-induced obese rats: vanillin and 4-hydroxybenzaldehyde are the bioactive candidates

(2010) Sunmin Park et al.   EUROPEAN JOURNAL OF NUTRITION

Hippocampal neurovascular and hypothalamic–pituitary–adrenal axis alterations in spontaneously type 2 diabetic GK rats

(2010) Juan Beauquis et al.   EXPERIMENTAL NEUROLOGY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY