Berberine Ameliorates Diabetes-Associated Cognitive Decline through Modulation of Aberrant Inflammation Response and Insulin Signaling Pathway in DM Rats

Age-Related Cognitive Decline in Hypercholesterolemic LDL Receptor Knockout Mice (LDLr−/−): Evidence of Antioxidant Imbalance and Increased Acetylcholinesterase Activity in the Prefrontal Cortex

(2018) Eduardo Luiz Gasnhar Moreira et al.   JOURNAL OF ALZHEIMERS DISEASE

Cognitive Dysfunctions in Middle-Aged Type 2 Diabetic Patients and Neuroimaging Correlations: A Cross-Sectional Study

(2018) Natalia García-Casares et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes

(2018) Tze Pin Ng et al.   JOURNAL OF ALZHEIMERS DISEASE

Resveratrol inhibits LPS-induced mice mastitis through attenuating the MAPK and NF-κB signaling pathway

(2017) Xu Zhang et al.   MICROBIAL PATHOGENESIS

Berberine Attenuates Intestinal Mucosal Barrier Dysfunction in Type 2 Diabetic Rats

(2017) Jing Gong et al.   Frontiers in Pharmacology

Metformin preconditioning provide neuroprotection through enhancement of autophagy and suppression of inflammation and apoptosis after spinal cord injury

(2016) Chen Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity

(2016) Xia Tian et al.   BRAIN RESEARCH

ST09, a Novel Thioester Derivative of Tacrine, Alleviates Cognitive Deficits and Enhances Glucose Metabolism in Vascular Dementia Rats

(2016) Jian-Min Liu et al.   CNS Neuroscience & Therapeutics

Acceleration of Amyloidosis by Inflammation in the Amyloid-Beta Marmoset Monkey Model of Alzheimer’s Disease

(2016) Ingrid H. Philippens et al.   JOURNAL OF ALZHEIMERS DISEASE

Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

(2016) Kalyana C. Nandipati et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer

(2016) Rajendra Karki et al.   NATURE

Interleukin-1β Plays a Pivotal Role via the PI3K/Akt/mTOR Signaling Pathway in the Chronicity of Mesial Temporal Lobe Epilepsy

(2016) Zhaohua Xiao et al.   NEUROIMMUNOMODULATION

Antidiabetic drugs restore abnormal transport of amyloid-β across the blood–brain barrier and memory impairment in db / db mice

(2016) Fang Chen et al.   NEUROPHARMACOLOGY

The neurocircuitry of remote cued fear memory

(2016) Hadley C. Bergstrom   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Insulin resistance and cognitive dysfunction

(2015) Lina Ma et al.   CLINICA CHIMICA ACTA

Regional Cerebral Hemodynamic Response to Incremental Exercise Is Blunted in Poorly Controlled Patients With Uncomplicated Type 1 Diabetes

(2015) Semah Tagougui et al.   DIABETES CARE

Current knowledge and pharmacological profile of berberine: An update

(2015) Anil Kumar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Aberrant functional connectivity of default-mode network in type 2 diabetes patients

(2015) Ying Cui et al.   EUROPEAN RADIOLOGY

Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPKSer-485Phosphorylation

(2015) Bhumsoo Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 2 diabetes mellitus and biomarkers of neurodegeneration

(2015) Chris Moran et al.   NEUROLOGY

Brain sites involved in fear memory reconsolidation and extinction of rodents

(2015) Elisabetta Baldi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Diabetes Mellitus Accelerates Aβ Pathology in Brain Accompanied by Enhanced GAβ Generation in Nonhuman Primates

(2015) Sachi Okabayashi et al.   PLoS One

Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus

(2014) Min Guo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

(2014) Chen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide

(2014) Krzysztof Łabuzek et al.   Pharmacological Reports

Berberine Protects against Neuronal Damage via Suppression of Glia-Mediated Inflammation in Traumatic Brain Injury

(2014) Chien-Cheng Chen et al.   PLoS One

Common biological mechanisms between bipolar disorder and type 2 diabetes: Focus on inflammation

(2014) Ajaykumar N. Sharma et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

PKC-epsilon activation is required for recognition memory in the rat

(2013) Styliani Zisopoulou et al.   BEHAVIOURAL BRAIN RESEARCH

In vitro biological assessment of berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects

(2013) Abeer E Abd El-Wahab et al.   BMC Complementary and Alternative Medicine

Brain Atrophy in Type 2 Diabetes: Regional distribution and influence on cognition

(2013) C. Moran et al.   DIABETES CARE

Diacylglycerol promotes GLUT4 translocation to the cell surface in a PKCε-dependent and PKCλ/ι and -ζ-independent manner

(2013) Ayako Tsuchiya et al.   LIFE SCIENCES

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation

(2013) João Soeiro Teodoro et al.   MITOCHONDRION

Morphometric Changes in Lateral Ventricles of Patients with Recent-Onset Type 2 Diabetes Mellitus

(2013) Junghyun H. Lee et al.   PLoS One

Prefrontal microcircuit underlies contextual learning after hippocampal loss

(2013) M. Zelikowsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of the anterior cingulate cortex in formation, consolidation, and reconsolidation of recent and remote contextual fear memory

(2012) E. O. Einarsson et al.   LEARNING & MEMORY

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

(2012) Jiejie Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

(2012) Chong Gao et al.   REVIEWS IN THE NEUROSCIENCES

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

(2011) Amit Gupta et al.   NEUROPHARMACOLOGY

Creatine Transporter (CrT; Slc6a8) Knockout Mice as a Model of Human CrT Deficiency

(2011) Matthew R. Skelton et al.   PLoS One

Redox Control of Protein Kinase C: Cell- and Disease-Specific Aspects

(2010) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Cannabinoid CB1 receptors in the medial prefrontal cortex modulate the expression of contextual fear conditioning

(2010) Sabrina F. Lisboa et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Induction of Fear Extinction with Hippocampal-Infralimbic BDNF

(2010) J. Peters et al.   SCIENCE

Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus

(2009) Hannah Bruehl et al.   BRAIN RESEARCH

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice

(2008) Dick Terwel et al.   AMERICAN JOURNAL OF PATHOLOGY

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL