Activation of mTOR signaling mediates the increased expression of AChE in high glucose condition: in vitro and in vivo evidences

Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells

(2014) Premranjan Kumar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effects of exposure to high glucose on primary cultured hippocampal neurons: involvement of intracellular ROS accumulation

(2013) Di Liu et al.   NEUROLOGICAL SCIENCES

Mammalian target of rapamycin signaling in diabetic cardiovascular disease

(2012) Zhao Chong et al.   Cardiovascular Diabetology

Tacrine-Silibinin Codrug Shows Neuro- and Hepatoprotective Effects in Vitro and Pro-Cognitive and Hepatoprotective Effects in Vivo

(2012) Xinyu Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes

(2011) Pravinkumar Bhutada et al.   BEHAVIOURAL BRAIN RESEARCH

Total saponins from Rhizoma Anemarrhenae ameliorate diabetes-associated cognitive decline in rats: Involvement of amyloid-beta decrease in brain

(2011) Yao-Wu Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Diabetes-Induced Central Cholinergic Neuronal Loss and Cognitive Deficit Are Attenuated by Tacrine and a Chinese Herbal Prescription, Kangen-Karyu: Elucidation in Type 2 Diabetes db/db Mice

(2011) Qi Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis

(2010) Zahra Faghiri et al.   EXPERIMENTAL EYE RESEARCH

TOR on the brain

(2010) Michael G. Garelick et al.   EXPERIMENTAL GERONTOLOGY

Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death

(2010) Masayuki Fukui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of combined treatment with vitamins C and E on passive avoidance learning and memory in diabetic rats

(2010) Parisa Hasanein et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced diabetic rats

(2010) Pravinkumar Bhutada et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Akt-dependent and -independent mechanisms of mTOR regulation in cancer

(2009) Regan M. Memmott et al.   CELLULAR SIGNALLING

Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats

(2009) Roberta Schmatz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Making synaptic plasticity and memory last: mechanisms of translational regulation

(2009) J. D. Richter et al.   GENES & DEVELOPMENT

Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

(2009) Emma Puighermanal et al.   NATURE NEUROSCIENCE

Diabetes Impairs Hippocampal Function via Advanced Glycation End Product Mediated New Neuron Generation in Animals with Diabetes-Related Depression

(2009) Shao-hua Wang et al.   TOXICOLOGICAL SCIENCES

Increased Nε-(carboxymethyl)-lysine levels in cerebral blood vessels of diabetic patients and in a (streptozotocin-treated) rat model of diabetes mellitus

(2008) A W van Deutekom et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Suppression of NF-κβ signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits

(2008) Anurag Kuhad et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR