Uraemia: an unrecognized driver of central neurohumoral dysfunction in chronic kidney disease?

Indoxyl sulphate and kidney disease: Causes, consequences and interventions

(2016) Robert J Ellis et al.   NEPHROLOGY

Indoxyl sulfate, not p-cresyl sulfate, is associated with cognitive impairment in early-stage chronic kidney disease

(2016) Yi-Chun Yeh et al.   NEUROTOXICOLOGY

Allopurinol and Progression of CKD and Cardiovascular Events: Long-term Follow-up of a Randomized Clinical Trial

(2015) Marian Goicoechea et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Vasopressin Receptor Antagonists, Heart Failure, and Polycystic Kidney Disease

(2015) Vicente E. Torres   Annual Review of Medicine

Protective cardiorenal effects of spironolactone in a rodent model of polycystic kidney disease

(2015) Thamarasee M Jeewandara et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters

(2015) S. K. Nigam et al.   Clinical Journal of the American Society of Nephrology

Long-term effects of AST-120 on the progression and prognosis of pre-dialysis chronic kidney disease: a 5-year retrospective study

(2015) Eiichi Sato et al.   HEART AND VESSELS

Abnormal central control underlies impaired baroreflex control of heart rate and sympathetic nerve activity in female Lewis polycystic kidney rats

(2015) Ibrahim M. Salman et al.   JOURNAL OF HYPERTENSION

The effect of losartan on differential reflex control of sympathetic nerve activity in chronic kidney disease

(2015) Yimin Yao et al.   JOURNAL OF HYPERTENSION

Compromised blood-brain barrier permeability: novel mechanism by which circulating angiotensin II signals to sympathoexcitatory centres during hypertension

(2015) V. C. Biancardi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tubular Secretion in CKD

(2015) A. M. Suchy-Dicey et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Uric acid, indoxyl sulfate, and methylguanidine activate bulbospinal neurons in the RVLM via their specific transporters and by producing oxidative stress

(2015) N. Oshima et al.   NEUROSCIENCE

Renal Denervation Suppresses Atrial Fibrillation in a Model of Renal Impairment

(2015) Zhuo Liang et al.   PLoS One

Direct conscious telemetry recordings demonstrate increased renal sympathetic nerve activity in rats with chronic kidney disease

(2015) Ibrahim M. Salman et al.   Frontiers in Physiology

Altered KLOTHO and NF-κB-TNF-α Signaling Are Correlated with Nephrectomy-Induced Cognitive Impairment in Rats

(2015) Sabrina Degaspari et al.   PLoS One

Renal Function Interferes with Copeptin in Prediction of Major Adverse Cardiac Events in Patients Undergoing Vascular Surgery

(2015) Claudia Schrimpf et al.   PLoS One

Superoxide anions in the paraventricular nucleus mediate cardiac sympathetic afferent reflex in insulin resistance rats

(2014) H.-J. Sun et al.   Acta Physiologica

Central exogenous nitric oxide decreases cardiac sympathetic drive and improves baroreflex control of heart rate in ovine heart failure

(2014) Rohit Ramchandra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Determinants of renal tissue hypoxia in a rat model of polycystic kidney disease

(2014) Connie P. C. Ow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Protein-bound Uremic Toxins, Inflammation and Oxidative Stress: A Cross-sectional Study in Stage 3–4 Chronic Kidney Disease

(2014) Megan Rossi et al.   ARCHIVES OF MEDICAL RESEARCH

Hippocampal transcriptional dysregulation after renal ischemia and reperfusion

(2014) An-Hsun Chou et al.   BRAIN RESEARCH

Kidney Function and Plasma Copeptin Levels in Healthy Kidney Donors and Autosomal Dominant Polycystic Kidney Disease Patients

(2014) D. Zittema et al.   Clinical Journal of the American Society of Nephrology

Copeptin Is Associated with Kidney Length, Renal Function, and Prevalence of Simple Cysts in a Population-Based Study

(2014) B. Ponte et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Abnormal urinary excretion of NKCC2 and AQP2 in response to hypertonic saline in chronic kidney disease: an intervention study in patients with chronic kidney disease and healthy controls

(2014) Janni M Jensen et al.   BMC Nephrology

Superoxide anions involved in sympathoexcitation and pressor effects of salusin-βin paraventricular nucleus in hypertensive rats

(2013) H.-J. Sun et al.   Acta Physiologica

Cardiovascular Burden Associated with Uremic Toxins in Patients with Chronic Kidney Disease

(2013) Hamid Moradi et al.   AMERICAN JOURNAL OF NEPHROLOGY

Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1)

(2013) Joachim Strobel et al.   AMINO ACIDS

Albumin is the main plasma binding protein for indoxyl sulfate andp-cresyl sulfate

(2013) Liesbeth Viaene et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Temporal development of baroreceptor dysfunction in a rodent model of chronic kidney disease

(2013) Cara M Hildreth et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Vasopressin and Oxytocin in Control of the Cardiovascular System

(2013) Nina Japundzic-Zigon   Current Neuropharmacology

Circulating Angiotensin II Gains Access to the Hypothalamus and Brain Stem During Hypertension via Breakdown of the Blood–Brain Barrier

(2013) Vinicia Campana Biancardi et al.   HYPERTENSION

Differential Contribution of Afferent and Central Pathways to the Development of Baroreflex Dysfunction in Chronic Kidney Disease

(2013) Ibrahim M. Salman et al.   HYPERTENSION

Feasibility of catheter-based renal nerve ablation and effects on sympathetic nerve activity and blood pressure in patients with end-stage renal disease

(2013) Markus P. Schlaich et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Physiological Regulation of Magnocellular Neurosecretory Cell Activity: Integration of Intrinsic, Local and Afferent Mechanisms

(2013) C. H. Brown et al.   JOURNAL OF NEUROENDOCRINOLOGY

p -Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase

(2013) Hiroshi Watanabe et al.   KIDNEY INTERNATIONAL

Numerous protein-bound solutes are cleared by the kidney with high efficiency

(2013) Tammy L. Sirich et al.   KIDNEY INTERNATIONAL

Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats

(2013) Maimaiti Yisireyili et al.   LIFE SCIENCES

Dendritic Peptide Release Mediates Interpopulation Crosstalk between Neurosecretory and Preautonomic Networks

(2013) Sook Jin Son et al.   NEURON

Intra-carotid angiotensin II activates tyrosine hydroxylase-expressing rostral ventrolateral medulla neurons following blood–brain barrier disruption in rats

(2013) S.T. Yao et al.   NEUROSCIENCE

Lipopolysaccharide-induced blood brain barrier permeability is enhanced by alpha-synuclein expression

(2013) Adam Jangula et al.   NEUROSCIENCE LETTERS

Serum Concentrations of p-Cresyl Sulfate and Indoxyl Sulfate, but Not Inflammatory Markers, Increase in Incident Peritoneal Dialysis Patients in Parallel with Loss of Residual Renal Function

(2013) L. Viaene et al.   PERITONEAL DIALYSIS INTERNATIONAL

Inhibition of TNF in the Brain Reverses Alterations in RAS Components and Attenuates Angiotensin II-Induced Hypertension

(2013) Srinivas Sriramula et al.   PLoS One

Inhibition of Oxidative Stress in Rostral Ventrolateral Medulla Improves Impaired Baroreflex Sensitivity in Stroke-Prone Spontaneously Hypertensive Rats

(2012) Kiyohiro Ogawa et al.   International Heart Journal

An update on uremic toxins

(2012) N. Neirynck et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells

(2012) M. A. Lopez-Ramirez et al.   JOURNAL OF IMMUNOLOGY

Creatinine clearance, cystatin C, beta2-microglobulin and TATI as markers of renal function in patients with proteinuria

(2012) Gianfranco Tramonti et al.   JOURNAL OF NEPHROLOGY

Autosomal dominant polycystic kidney disease is associated with central and nephrogenic defects in osmoregulation

(2012) Thien Anh Ho et al.   KIDNEY INTERNATIONAL

Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension: a meta-analysis

(2012) Bakhtawar K Mahmoodi et al.   LANCET

Indoxyl sulfate enhances angiotensin II signaling through upregulation of epidermal growth factor receptor expression in vascular smooth muscle cells

(2012) Hidehisa Shimizu et al.   LIFE SCIENCES

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Uremic Toxins Induce Kidney Fibrosis by Activating Intrarenal Renin–Angiotensin–Aldosterone System Associated Epithelial-to-Mesenchymal Transition

(2012) Chiao-Yin Sun et al.   PLoS One

Estimated Glomerular Filtration Rate Is a Poor Predictor of the Concentration of Middle Molecular Weight Uremic Solutes in Chronic Kidney Disease

(2012) Nathalie Neirynck et al.   PLoS One

Inflammatory cytokines in paraventricular nucleus modulate sympathetic activity and cardiac sympathetic afferent reflex in rats

(2011) Z. Shi et al.   Acta Physiologica

NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells

(2011) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Roles of organic anion/cation transporters at the blood–brain and blood–cerebrospinal fluid barriers involving uremic toxins

(2011) Ken-ichi Hosoya et al.   Clinical and Experimental Nephrology

Sympathetic Nerve Traffic and Asymmetric Dimethylarginine in Chronic Kidney Disease

(2011) G. Grassi et al.   Clinical Journal of the American Society of Nephrology

Estimated Glomerular Filtration Rate Is a Poor Predictor of Concentration for a Broad Range of Uremic Toxins

(2011) S. Eloot et al.   Clinical Journal of the American Society of Nephrology

Angiotensin II and angiotensin-1-7 redox signaling in the central nervous system

(2011) Matthew C Zimmerman   CURRENT OPINION IN PHARMACOLOGY

Early Sympathetic Activation in the Initial Clinical Stages of Chronic Renal Failure

(2011) Guido Grassi et al.   HYPERTENSION

Atorvastatin reduces sympathetic activity in patients with chronic kidney disease

(2011) Laima Siddiqi et al.   JOURNAL OF HYPERTENSION

Inhibitory-excitatory synaptic balance is shifted toward increased excitation in magnocellular neurosecretory cells of heart failure rats

(2011) Evgeniy S. Potapenko et al.   JOURNAL OF NEUROPHYSIOLOGY

Colonic Contribution to Uremic Solutes

(2011) P. A. Aronov et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Potential Deleterious Effects of Vasopressin in Chronic Kidney Disease and Particularly Autosomal Dominant Polycystic Kidney Disease

(2011) E. Meijer et al.   KIDNEY & BLOOD PRESSURE RESEARCH

The contribution of chronic kidney disease to the global burden of major noncommunicable diseases

(2011) William G. Couser et al.   KIDNEY INTERNATIONAL

Serum free p-cresyl sulfate levels predict cardiovascular and all-cause mortality in elderly hemodialysis patients--a prospective cohort study

(2011) I.-W. Wu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The gut-kidney axis: indoxyl sulfate, p-cresyl sulfate and CKD progression

(2011) B. K. I. Meijers et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

An Obituary for GFR as the Main Marker for Kidney Function?

(2011) Raymond Vanholder et al.   SEMINARS IN DIALYSIS

Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: Investigation of nicotinic acid receptor agonists

(2011) Joanna R. Zgoda-Pols et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Exaggerated Natriuresis in Adult Polycystic Kidney Disease

(2010) HENNING DANIELSEN et al.   ACTA MEDICA SCANDINAVICA

Superoxide scavenging in the rostral ventrolateral medulla blunts the pressor response to peripheral chemoreflex activation

(2010) Fabíola C. Nunes et al.   BRAIN RESEARCH

Circulating levels of asymmetric dimethylarginine are an independent risk factor for left ventricular hypertrophy and predict cardiovascular events in pre-dialysis patients with chronic kidney disease

(2010) Beili Shi et al.   European Journal of Internal Medicine

Kidney-Induced Hypertension Depends on Superoxide Signaling in the Rostral Ventrolateral Medulla

(2010) Elizabeth B. Oliveira-Sales et al.   HYPERTENSION

Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis

(2010)   LANCET

Sympathetic activity in chronic kidney disease patients is related to left ventricular mass despite antihypertensive treatment

(2010) L. Siddiqi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Electrolyte Management in Frequent Home Hemodialysis

(2010) Rhonda S. King et al.   SEMINARS IN DIALYSIS

Reactive oxygen species in rostral ventrolateral medulla modulate cardiac sympathetic afferent reflex in rats

(2009) M.-K. Zhong et al.   Acta Physiologica

Indoxyl Sulfate Inhibits Nitric Oxide Production and Cell Viability by Inducing Oxidative Stress in Vascular Endothelial Cells

(2009) Zohra Tumur et al.   AMERICAN JOURNAL OF NEPHROLOGY

IL-6 microinjected in the nucleus tractus solitarii attenuates cardiac baroreceptor reflex function in rats

(2009) Miwa Takagishi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Central sympathetic overactivity: Maladies and mechanisms

(2009) James P. Fisher et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2

(2009) Naoko Kimura et al.   BIOCHEMICAL PHARMACOLOGY

Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension

(2009) Y.-M. Kang et al.   CARDIOVASCULAR RESEARCH

Sympathetic nerves and the progression of chronic kidney disease during 5/6 nephrectomy: Studies in sympathectomized rats

(2009) Robert A Augustyniak et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Role of Residual Kidney Function and Convective Volume on Change in  2-Microglobulin Levels in Hemodiafiltration Patients

(2009) E. L. Penne et al.   Clinical Journal of the American Society of Nephrology

Serum Indoxyl Sulfate Is Associated with Vascular Disease and Mortality in Chronic Kidney Disease Patients

(2009) F. C. Barreto et al.   Clinical Journal of the American Society of Nephrology

Exercise-induced neuronal plasticity in central autonomic networks: role in cardiovascular control

(2009) Lisete C. Michelini et al.   EXPERIMENTAL PHYSIOLOGY

Nocturnal home hemodialysis improves baroreflex effectiveness index of end-stage renal disease patients

(2009) Christopher T Chan et al.   JOURNAL OF HYPERTENSION

Inhibition of nitric oxide synthase evokes central sympatho-excitation in healthy humans

(2009) Colin N. Young et al.   JOURNAL OF PHYSIOLOGY-LONDON

V1/V2 Vasopressin receptor antagonism potentiates the renoprotection of renin–angiotensin system inhibition in rats with renal mass reduction

(2009) Norberto Perico et al.   KIDNEY INTERNATIONAL

CNS penetration of small molecules following local inflammation, widespread systemic inflammation or direct injury to the nervous system

(2009) Peimin Lu et al.   LIFE SCIENCES

Parasympathetic regulation of heart rate in rats after 5/6 nephrectomy is impaired despite functionally intact cardiac vagal innervation

(2009) J. Kuncova et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Neuronal activation in the CNS during different forms of acute renal failure in rats

(2009) M. Palkovits et al.   NEUROSCIENCE

Estrogen Protects against Oxidative Multiorgan Damage in Rats with Chronic Renal Failure

(2009) Özgür Kasımay et al.   RENAL FAILURE

Guanidino Compounds as Uremic (Neuro)Toxins

(2009) Peter Paul De Deyn et al.   SEMINARS IN DIALYSIS

The blood-brain barrier in brain homeostasis and neurological diseases

(2008) Nicolas Weiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Acute Kidney Injury Leads to Inflammation and Functional Changes in the Brain

(2008) M. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Bench to Bedside View of Uremic Toxins

(2008) R. Vanholder et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Free p-cresol is associated with cardiovascular disease in hemodialysis patients

(2008) B.K.I. Meijers et al.   KIDNEY INTERNATIONAL

Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease

(2008) Victoria Cachofeiro et al.   KIDNEY INTERNATIONAL

Associations of serum uric acid with cardiovascular events and mortality in moderate chronic kidney disease

(2008) S. D. Navaneethan et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats

(2008) A. Adijiang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION