Article
Cardiac & Cardiovascular Systems
Emanuele Barbato, Michel Azizi, Roland E. Schmieder, Lucas Lauder, Michael Boehm, Sofie Brouwers, Rosa Maria Bruno, Dariusz Dudek, Thomas Kahan, David E. Kandzari, Thomas F. Luscher, Gianfranco Parati, Atul Pathak, Flavio L. Ribichini, Markus P. Schlaich, Andrew S. P. Sharp, Isabella Sudano, Massimo Volpe, Costas Tsioufis, William Wijns, Felix Mahfoud
Summary: Since the publication of the 2018 ESC/ESH Guidelines, high-quality studies have confirmed the efficacy and safety of RDN in patients with hypertension. The consensus document recommends RDN as an adjunct treatment for uncontrolled resistant hypertension and for patients who cannot tolerate antihypertensive medications. A shared decision-making process is crucial, taking into account the patient's overall cardiovascular risk and the presence of hypertension-mediated organ damage or complications. Multidisciplinary hypertension teams involving experts and interventionalists are needed to evaluate indications and perform RDN procedures. Future research should focus on clinical outcomes and potential indications beyond hypertension.
EUROPEAN HEART JOURNAL
(2023)
Review
Transplantation
Roland E. Schmieder
Summary: Supported by clinical evidence, renal denervation is becoming an important treatment option for hypertension, particularly in hypertensive patients with chronic kidney disease. Its potential nephroprotective effects are also being studied.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Michael J. Bloch, Michel Azizi, Yale Wang, Roland E. Schmieder, Melvin D. Lobo, Andrew S. P. Sharp, Joost Daemen, Jan Basile, Michael A. Weber, Andrea P. Scicli, Candace K. McClure, Ajay J. Kirtane
Summary: In the RADIANCE-HTN SOLO study, patients originally assigned to a sham procedure who crossed over to receive ultrasound RDN treatment showed significant reductions in blood pressure during long-term follow-up, with no major procedure-related adverse events.
Article
Cardiac & Cardiovascular Systems
Yu Sato, Andrew S. P. Sharp, Felix Mahfoud, Stefan Tunev, Ashley Forster, Matthew Ellis, Ana Gomez, Roma Dhingra, Jeremy Ullman, Markus Schlaich, David Lee, Julie Trudel, Douglas A. Hettrick, David E. Kandzari, Renu Virmani, Aloke V. Finn
Summary: The distribution of nerve tissue along the renal artery in normotensive pigs is similar to that in humans, validating the translational value of the porcine model for RF-RDN.
Article
Cardiac & Cardiovascular Systems
Michael Boehm, Konstantinos Tsioufis, David E. Kandzari, Kazuomi Kario, Michael A. Weber, Roland E. Schmieder, Raymond R. Townsend, Saarraaken Kulenthiran, Christian Ukena, Stuart Pocock, Sebastian Ewen, Joachim Weil, Martin Fahy, Felix Mahfoud
Summary: This analysis evaluated the impact of baseline heart rate on blood pressure reduction after renal denervation. The results showed a greater reduction in blood pressure at 3 months post renal denervation for patients with baseline heart rate >= 70 beats/min.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Roland E. Schmieder, Felix Mahfoud, Giuseppe Mancia, Michael Azizi, Michael Boehm, Kyriakos Dimitriadis, Kazuomi Kario, Abraham A. Kroon, Melvin D. Lobo, Christian Ott, Atul Pathak, Alexandre Persu, Filippo Scalise, Markus Schlaich, Reinhold Kreutz, Costas Tsioufis
Summary: This paper presents updated recommendations based on new pivotal sham-controlled randomized clinical trials, demonstrating the efficacy and safety of endovascular device-based renal denervation for hypertension treatment. Meta-analyses show a significant reduction in blood pressure and a decreased incidence of cardiovascular events with this treatment option.
JOURNAL OF HYPERTENSION
(2021)
Review
Peripheral Vascular Disease
Kenichi Katsurada, Keisuke Shinohara, Jiro Aoki, Shinsuke Nanto, Kazuomi Kario
Summary: Renal nerves play a critical role in regulating blood pressure and fluid volume, with dysfunction implicated in cardiovascular diseases. Afferent renal sensory nerves project to the hypothalamus to modulate sympathetic outflow, while efferent renal sympathetic nerves affect renin secretion and vascular resistance. Studies on renal denervation show promise for treating hypertension and heart failure in both basic and clinical research settings.
HYPERTENSION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Karl Fengler, Karl-Philipp Rommel, Wenzel Kriese, Karl-Patrik Kresoja, Stephan Blazek, Danilo Obradovic, Hans-Josef Feistritzer, Christian Lucke, Matthias Gutberlet, Steffen Desch, Holger Thiele, Philipp Lurz
Summary: This study aimed to assess the ability of invasive and non-invasive methods to predict the response of blood pressure to renal sympathetic denervation (RDN). The results showed that iPWV is an independent predictor for blood pressure response after RDN, and non-invasive methods can also predict blood pressure changes.
Review
Peripheral Vascular Disease
Kazuomi Kario, Douglas A. Hettrick, Aleksander Prejbisz, Andrzej Januszewicz
Summary: There is a bidirectional, causal relationship between obstructive sleep apnea (OSA) and hypertension, with hypoxia/hypercapnia-related sympathetic activation being the key mechanism. While continuous positive airway pressure is the gold standard therapy for OSA, its effects on blood pressure are modest. Antihypertensive agents targeting sympathetic pathways or the renin-angiotensin-aldosterone system may have potential in patients with comorbid hypertension and OSA.
Article
Biochemistry & Molecular Biology
Lu-Lu Wu, Yue Zhang, Xiu-Zhen Li, Xin-Li Du, Ying Gao, Jing-Xiao Wang, Xiao-Li Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiao Tan
Summary: Selective renal afferent denervation attenuated sympathetic activity, oxidative stress, vascular remodeling, and hypertension in spontaneously hypertensive rats (SHR).
Article
Multidisciplinary Sciences
An Nu-Khanh Ton, Shin-Huei Liu, Li-Wei Lo, Thien Chuong-Nguyen Khac, Yu-Hui Chou, Wen-Han Cheng, Wei-Lun Lin, Tzu-Yen Peng, Pin-Yi Lin, Shih-Lin Chang, Shih-Ann Chen
Summary: Renal artery denervation (RDN) leads to electrical remodeling and reduces ventricular arrhythmia (VA) inducibility in LQTS models.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Marius Nistor, Martin Schmidt, Carsten Klingner, Caroline Klingner, Matthias Schwab, Sabine Juliane Bischoff, Georg Matziolis, Guadalupe Leticia Rodriguez-Gonzalez, Rene Schiffner
Summary: The study demonstrated that prenatal dexamethasone injection may impact HPAA, reducing renal glucose release during hypoglycaemia while maintaining renal function parameters unchanged and significantly increasing urinary sodium excretion. Specimens with elevated HPAA may undergo long-term adaptations to maintain glucose homeostasis, but the decrease in renal net glucose release warrants further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Urology & Nephrology
Jimena Rey, Raymond R. Townsend
Summary: Uncontrolled hypertension remains a significant health problem despite the availability of various medications and therapies. Device-based methods that denervate the renal arteries are emerging as potential alternatives to standard antihypertensive treatments, which often require daily medication or physical activity. This review summarizes the mechanisms, efficacy, and safety of renal artery denervation, and discusses the challenges in this rapidly evolving field.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Peripheral Vascular Disease
Gianni Sesa-ashton, Janis M. Nolde, Ida Muente, Revathy Carnagarin, Rebecca Lee, Vaughan G. Macefield, Tye Dawood, Yusuke Sata, Elisabeth A. Lambert, Gavin W. Lambert, Antony Walton, Marcio G. Kiuchi, Murray D. Esler, Markus P. Schlaich
Summary: Long-term follow-up studies on catheter-based renal denervation in patients with resistant hypertension show that the method can still effectively reduce blood pressure and decrease medication usage after nearly 9 years of follow-up, without any adverse effects on renal function.
Review
Cardiac & Cardiovascular Systems
Le Li, Yulong Xiong, Zhao Hu, Yan Yao
Summary: This meta-analysis found that renal denervation can reduce heart rate in patients with hypertension, especially office, 24-hour, and daytime heart rate, but it has no significant effect on nighttime heart rate. Additionally, the reduction in heart rate is closely associated with decreased blood pressure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Rehabilitation
Clara C. Zwack, Rachael McDonald, Ainura Tursunalieva, Shradha Vasan, Gavin W. Lambert, Elisabeth A. Lambert
Summary: The study showed that adults with intellectual disabilities experience higher levels of perceived stress compared to those without disabilities, likely due to unique stressors they face. Stress is strongly associated with social isolation, obesity in females with mild intellectual disabilities, and arterial stiffness.
DISABILITY AND REHABILITATION
(2023)
Article
Peripheral Vascular Disease
Norm R. C. Campbell, Paul K. Whelton, Marcelo Orias, Richard D. Wainford, Francesco P. Cappuccio, Nicole Ide, Bruce Neal, Jennifer Cohn, Laura K. Cobb, Jacqui Webster, Kathy Trieu, Feng J. He, Rachael M. McLean, Adriana Blanco-Metzler, Mark Woodward, Nadia Khan, Yoshihiro Kokubo, Leo Nederveen, JoAnne Arcand, Graham A. MacGregor, Mayowa O. Owolabi, Liu Lisheng, Gianfranco Parati, Daniel T. Lackland, Fadi J. Charchar, Bryan Williams, Maciej Tomaszewski, Cesar A. Romero, Beatriz Champagne, Mary R. L'Abbe, Michael A. Weber, Markus P. Schlaich, Agnes Fogo, Valery L. Feigin, Rufus Akinyemi, Felipe Inserra, Bindu Menon, Marcia Simas, Mario Fritsch Neves, Krassimira Hristova, Carolyn Pullen, Sanjay Pandeya, Junbo Ge, Jorge E. Jalil, Ji-Guang Wang, Jiri Wideimsky, Reinhold Kreutz, Ulrich Wenzel, Michael Stowasser, Manuel Arango, Athanasios Protogerou, Eugenia Gkaliagkousi, Flavio Danni Fuchs, Mansi Patil, Andy Wai-Kwong Chan, Janos Nemcsik, Ross T. Tsuyuki, Sanjeevi Nathamuni Narasingan, Nizal Sarrafzadegan, Maria Eugenia Ramos, Natalie Yeo, Hiromi Rakugi, Agustin J. Ramirez, Guillermo Alvarez, Adel Berbari, Cho-il Kim, Sang-Hyun Ihm, Yook-Chin Chia, Tsolmon Unurjargal, Hye Kyung Park, Kolawole Wahab, Helen McGuire, Naranjargal J. Dashdorj, Mohammed Ishaq, Deborah Ignacia D. Ona, Leilani B. Mercado-Asis, Aleksander Prejbisz, Marianne Leenaerts, Carla Simao, Fernando Pinto, Bader Ali Almustafa, Jonas Spaak, Stefan Farsky, Dragan Lovic, Xin-Hua Zhang
JOURNAL OF HUMAN HYPERTENSION
(2023)
Review
Cardiac & Cardiovascular Systems
Edgar M. Hidalgo, Leah Wright, Mats Isaksson, Gavin Lambert, Thomas H. Marwick
Summary: With advances in robotics and telecommunications, robot-assisted teleoperated ultrasound examination can help with medical diagnosis in remote areas, reducing health inequalities. Studies have shown that robots can safely perform ultrasound examinations by following the hand movements of sonographers and researchers. However, real-time transmission of video and ultrasound images requires high bandwidth, and improvements are needed in robot control and interface design.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Roland E. Schmieder, Felix Mahfoud, Giuseppe Mancia, Krzysztof Narkiewicz, Luis Ruilope, David Hutton, Khoa Cao, Douglas A. Hettrick, Martin Fahy, Markus P. Schlaich, Michael Bohm, Jan B. Pietzsch
Summary: Renal denervation using radiofrequency has been found to lower blood pressure and reduce cardiovascular events in patients with uncontrolled hypertension. The magnitude of blood pressure reduction and associated risks of cardiovascular events vary among different high-risk subgroups. Model-based projections suggest that radiofrequency renal denervation provides significant clinical benefits for patients with uncontrolled hypertension.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Peripheral Vascular Disease
Revathy Carnagarin, Janis M. Nolde, Jun Yang, Francine Z. Marques, Dean S. Picone, Gavin W. Lambert, Thomas Beaney, Neil R. Poulter, Aletta E. Schutte, Christopher M. Reid, Derrin Brockman, Markus P. Schlaich
Summary: The awareness, treatment, and control rates of hypertension in Australia are substantially lower than global and high-income country rates, indicating the need for collaborative efforts to improve the situation.
JOURNAL OF HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Felix Mahfoud, Giuseppe Mancia, Roland E. Schmieder, Luis Ruilope, Krzysztof Narkiewicz, Markus Schlaich, Bryan Williams, Flavio Ribichini, Joachim Weil, Khaled Almerri, Faisal Sharif, Lucas Lauder, Marianne Wanten, Martin Fahy, Michael Boehm
Summary: This study investigated whether the number or type of antihypertensive medications were associated with increased long-term blood pressure reductions and cardiovascular outcomes following radiofrequency renal denervation (RDN) in hypertensive patients. The results showed that radiofrequency RDN reduced blood pressure safely through 36 months, regardless of the number and type of baseline antihypertensive medication classes.
Article
Peripheral Vascular Disease
Gianni Sesa-ashton, Janis M. Nolde, Ida Muente, Revathy Carnagarin, Rebecca Lee, Vaughan G. Macefield, Tye Dawood, Yusuke Sata, Elisabeth A. Lambert, Gavin W. Lambert, Antony Walton, Marcio G. Kiuchi, Murray D. Esler, Markus P. Schlaich
Summary: Long-term follow-up studies on catheter-based renal denervation in patients with resistant hypertension show that the method can still effectively reduce blood pressure and decrease medication usage after nearly 9 years of follow-up, without any adverse effects on renal function.
Review
Peripheral Vascular Disease
Marcio Galindo Kiuchi, Revathy Carnagarin, Vance B. Matthews, Markus P. Schlaich
Summary: Cardiometabolic disorders have a significant impact on quality of life and healthcare systems globally, and the overactivation of the sympathetic nervous system is a key factor in these conditions. Although diet and exercise are traditional methods for combating metabolic disorders, they can be difficult to achieve. Current pharmaceutical approaches have variable effectiveness and may be limited by side effects and non-adherence. Complementary therapies, such as neural modulation, may be beneficial in addressing the burden of cardiometabolic disease.
HYPERTENSION RESEARCH
(2023)
Article
Medicine, General & Internal
Michel Azizi, Manish Saxena, Yale Wang, J. Stephen Jenkins, Chandan Devireddy, Florian Rader, Naomi D. L. Fisher, Roland E. Schmieder, Felix Mahfoud, Jason Lindsey, Kintur Sanghvi, Thomas M. Todoran, John Pacella, John Flack, Joost Daemen, Andrew S. P. Sharp, Philipp Lurz, Michael J. Bloch, Michael A. Weber, Melvin D. Lobo, Jan Basile, Lisa Claude, Helen Reeve-Stoffer, Candace K. McClure, Ajay J. Kirtane
Summary: Two studies showed that ultrasound renal denervation can reduce blood pressure in patients with mild to moderate hypertension and treatment-resistant hypertension. This study aimed to investigate the efficacy and safety of ultrasound renal denervation without the influence of antihypertensive medications. The results of a randomized clinical trial demonstrated that ultrasound renal denervation can significantly reduce daytime ambulatory systolic blood pressure in hypertensive patients at 2 months.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Lakshini Yasaswi Herat, Jennifer Rose Matthews, Moira Hibbs, Elizabeth Piroska Rakoczy, Markus Peter Schlaich, Vance Bruce Matthews
Summary: SGLTs are transport proteins that can be inhibited to improve glycemic control and provide cardiorenal benefits. Dual SGLT1/2 inhibitors, such as sotagliflozin, target both SGLT1 and 2 proteins.
Article
Health Care Sciences & Services
Mansi Patil, Radhika Prashant Hedaoo, Rohan Pravinbhai Shah, Syed Mohammad Tauseef, Roy Rillera Marzo, Siew Mooi Ching, Gavin Lambert
Summary: The burden of hypertension has been increasing, and besides the risk of stroke and cardiovascular disease, it also affects the quality of life (QoL) of individuals. This study aimed to assess the QoL of hypertensive men undergoing treatment in India. The results showed that patients with uncontrolled hypertension had significantly poorer QoL compared to those with controlled blood pressure.
INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
(2023)
Article
Peripheral Vascular Disease
Sonali R. Gnanenthiran, Vivekanand Jha, Abdul Salam, Emily Atkins, Clara K. Chow, Mark R. Nelson, Mike Rakotz, Markus P. Schlaich, Aletta E. Schutte, Tim Usherwood, Anthony Rodgers
Summary: In this study, we assessed whether pooled cardiovascular expertise could accurately predict the efficacy and tolerability of both a novel and an established treatment option. A survey was conducted to collect predictions of blood pressure at 12 weeks and 52 weeks for participants in a trial called QUARTET, which involved two different treatment groups.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Review
Biochemistry & Molecular Biology
Jennifer Matthews, Lakshini Herat, Markus P. Schlaich, Vance Matthews
Summary: Chronic Kidney Disease (CKD) and Cardiovascular Disease (CVD) can occur together as cardiorenal disease. Sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors show promise in treating cardiorenal disease by improving various indicators through multiple mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)