Repairing the Brain: Cell Replacement Using Stem Cell-Based Technologies

New approaches for brain repair—from rescue to reprogramming

(2018) Roger A. Barker et al.   NATURE

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

(2017) Tetsuhiro Kikuchi et al.   NATURE

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

(2017) Pia Rivetti di Val Cervo et al.   NATURE BIOTECHNOLOGY

Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation

(2017) Sara Nolbrant et al.   Nature Protocols

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

MHC matching improves engraftment of iPSC-derived neurons in non-human primates

(2017) Asuka Morizane et al.   Nature Communications

IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells

(2017) Daniela Lehnen et al.   Stem Cell Reports

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons

(2017) Maria Pereira et al.   Stem Cell Reports

Amelioration of non-motor dysfunctions after transplantation of human dopamine neurons in a model of Parkinson's disease

(2016) M.J. Lelos et al.   EXPERIMENTAL NEUROLOGY

A decade of transcription factor-mediated reprogramming to pluripotency

(2016) Kazutoshi Takahashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor

(2016) Patrick Aldrin-Kirk et al.   NEURON

Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson's disease model

(2015) Julius A Steinbeck et al.   NATURE BIOTECHNOLOGY

Cell-based therapies for Parkinson disease—past insights and future potential

(2015) Roger A. Barker et al.   Nature Reviews Neurology

In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry

(2015) Olof Torper et al.   Cell Reports

Pharmacological Treatment of Parkinson Disease

(2014) Barbara S. Connolly et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain

(2014) Maria Pereira et al.   Scientific Reports

Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation

(2014) Daisuke Doi et al.   Stem Cell Reports

Generation of induced neurons via direct conversion in vivo

(2013) O. Torper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease

(2013) Zinovia Kefalopoulou et al.   JAMA Neurology

Intrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson's disease: a double-blind, randomised, controlled trial

(2011) Robert E Gross et al.   LANCET NEUROLOGY

Graft-induced dyskinesias in Parkinson's disease: High striatal serotonin/dopamine transporter ratio

(2011) Marios Politis et al.   MOVEMENT DISORDERS

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

(2011) Massimiliano Caiazzo et al.   NATURE

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Direct conversion of human fibroblasts to dopaminergic neurons

(2011) U. Pfisterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Pathologic findings in retinal pigment epithelial cell implantation for Parkinson disease

(2009) E. S. Farag et al.   NEUROLOGY