T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics

Targeting PRPK Function Blocks Colon Cancer Metastasis

(2018) Tatyana Zykova et al.   MOLECULAR CANCER THERAPEUTICS

The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis

(2017) Tatyana A. Zykova et al.   EBioMedicine

Overexpression of PBK/TOPK Contributes to Tumor Development and Poor Outcome of Esophageal Squamous Cell Carcinoma

(2016) TAKUMA OHASHI et al.   ANTICANCER RESEARCH

Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma

(2016) Takuma Ohashi et al.   BRITISH JOURNAL OF CANCER

T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer

(2016) Y. Ikeda et al.   CLINICAL CANCER RESEARCH

Identification of Predictive Gene Markers for Multipotent Stromal Cell Proliferation

(2016) Ian H. Bellayr et al.   STEM CELLS AND DEVELOPMENT

PBK/TOPK expression correlates with mutant p53 and affects patients' prognosis and cell proliferation and viability in lung adenocarcinoma

(2015) Bin Lei et al.   HUMAN PATHOLOGY

Overexpression of PDZ-binding kinase confers malignant phenotype in prostate cancer via the regulation of E2F1

(2015) Jia-Hong Chen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

(2015) Margaret M. Mc Gee   MEDIATORS OF INFLAMMATION

Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo

(2015) Mrinal Joel et al.   Molecular Cancer

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia

(2015) Houda Alachkar et al.   Oncotarget

Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins

(2015) Raed Rizkallah et al.   Oncotarget

TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis

(2014) Y. Matsuo et al.   Science Translational Medicine

Ischemic Postconditioning Relieves Cerebral Ischemia and Reperfusion Injury Through Activating T-LAK Cell–Originated Protein Kinase/Protein Kinase B Pathway in Rats

(2014) Haiping Zhao et al.   STROKE

T-LAK cell-originated protein kinase is essential for the proliferation of hepatocellular carcinoma SMMC-7721 cells

(2013) Fang Chen et al.   CELL BIOCHEMISTRY AND FUNCTION

Novel TOPK Inhibitor HI-TOPK-032 Effectively Suppresses Colon Cancer Growth

(2012) D. J. Kim et al.   CANCER RESEARCH

Phosphorylation of IκBα at Serine 32 by T-lymphokine-activated Killer Cell-originated Protein Kinase Is Essential for Chemoresistance against Doxorubicin in Cervical Cancer Cells

(2012) Jung-Hwan Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global mitotic phosphorylation of C2H2zinc finger protein linker peptides

(2011) Raed Rizkallah et al.   CELL CYCLE

T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of MKP1 Protein Prevents Solar Ultraviolet Light-induced Inflammation through Inhibition of the p38 Protein Signaling Pathway

(2011) Shengqing Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer/Testis antigens as potential predictors of biochemical recurrence of prostate cancer following radical prostatectomy

(2011) Takumi Shiraishi et al.   Journal of Translational Medicine

VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal patients

(2011) Tatjana Vlajnic et al.   MODERN PATHOLOGY

Using a Stem Cell-Based Signature to Guide Therapeutic Selection in Cancer

(2010) I. Shats et al.   CANCER RESEARCH

PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells

(2010) Edita Aksamitiene et al.   CELLULAR SIGNALLING

Emerging MEK inhibitors

(2010) James A McCubrey et al.   EXPERT OPINION ON EMERGING DRUGS

T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of Prx1 at Ser-32 Prevents UVB-induced Apoptosis in RPMI7951 Melanoma Cells through the Regulation of Prx1 Peroxidase Activity

(2010) Tatyana A. Zykova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21

(2010) F Hu et al.   ONCOGENE

Targeting the RAF–MEK–ERK pathway in cancer therapy

(2009) Clara Montagut et al.   CANCER LETTERS

Critical roles of T-LAK cell-originated protein kinase in cytokinesis

(2009) Jae-Hyun Park et al.   CANCER SCIENCE

PBK/TOPK in the differential diagnosis of cholangiocarcinoma from hepatocellular carcinoma and its involvement in prognosis of human cholangiocarcinoma

(2009) Furong He et al.   HUMAN PATHOLOGY

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SharedTP53gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate

(2009) Donna E. Hansel et al.   PROSTATE