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Multidisciplinary Sciences
Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu Saito, Mariko Shimokawa, Shingo Nishikori, Yoshiko Hatano, Ryota Ishii, Kazuaki Sawada, Akihito Machinaga, Wataru Ikeda, Takeshi Imamura, Toshiro Sato
Summary: This study develops an experimental platform for tracking cancer stem cells in colorectal cancer and identifies dormant LGR5(+) cancer stem cells. Transcriptome analysis reveals an upregulation of cell-adhesion molecule COL17A1 in dormant cancer stem cells, and chemotherapy disrupts this dormancy through FAK-YAP activation. Inhibition of YAP signaling prevents chemoresistant cells from exiting dormancy and delays tumor regrowth.
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Integrative & Complementary Medicine
Rong Cai, Yan-Ping Zhou, Yun-Hai Li, Jin-Jin Zhang, Zuo-Wei Hu
Summary: This study found that baicalin can promote apoptosis of colon cells and inhibit tumor growth. It was discovered that baicalin regulates the miR-139-3p/CDK16 pathway to inhibit proliferation and growth of colon cancer cells.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
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Oncology
Jiankang Kang, Yanping Zhong, Wei Tian, Junying Li, Xinxiao Li, Lina Zhai, Huaxin Hou, Danrong Li
Summary: The study synthesized a novel anthraquinone-quinazoline hybrid 7B targeting EGFR and Rac1 in TNBC cells, demonstrating superior antiproliferative activity compared to Rhein and gefitinib. Functional assays indicated that hybrid 7B significantly reduced cell viability, induced apoptosis, and inhibited invasion and migration by regulating EMT markers and metastasis-related proteins in TNBC cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour, Nikolay V. Dokholyan
Summary: The low efficiency of cancer treatment strategies is a major obstacle in developing cancer inhibitors. Peptidomimetics, a new class of agents, have been introduced to overcome the limitations of peptides and have shown effectiveness in inhibiting metastasis, angiogenesis, and cancerous cell growth.
MOLECULAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Cheng-lin Li, Juan Li, Shu-yuan Gong, Meng Huang, Rui Li, Gui-xiang Xiong, Fan Wang, Qiu-ming Zou, Qi Qi, Xiao-xing Yin
Summary: The study showed that LFG-500 can inhibit EMT-associated migration and invasion in breast cancer and lung adenocarcinoma cell lines by downregulating YAP activity. Further research indicated that the suppression of YAP activation induced by LGF-500 is mediated by ILK.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Shengbo Han, Decai Wang, Yan Huang, Zhu Zeng, Peng Xu, Hewei Xiong, Zunxiang Ke, Ya Zhang, Yuhang Hu, Fan Wang, Jie Wang, Yong Zhao, Wenfeng Zhuo, Gang Zhao
Summary: Research has shown that the emergence of Schwann cells around premalignant lesions of colon cancer may be an early indicator promoting tumorigenesis. This study explored the communication between colon cancer cells and Schwann cells, and identified NGF and exosomal miR-21-5p as potential therapeutic targets for colon cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Han Seok Koh, SangJoon Lee, Hyo Jin Lee, Jae-Woong Min, Takeshi Iwatsubo, Charlotte E. Teunissen, Hyun-Jeong Cho, Jin-Hyeob Ryu
Summary: Treatment with miR-485-3p ASO reduces A beta plaque accumulation, tau pathology development, neuroinflammation, and cognitive decline in an AD transgenic mouse model by enhancing A beta clearance and reducing apoptosis. Additionally, miR-485-3p ASO administration decreases proinflammatory cytokine secretion, ultimately alleviating cognitive impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Giovanni Monteleone, Claudia Maresca, Marco Colella, Teresa Pacifico, Daniele Congiu, Edoardo Troncone, Irene Marafini
Summary: This article reviews the current understanding of the involvement of interleukin-34 (IL-34) and its receptor, macrophage colony-stimulating factor-1 receptor (MCSF-1R), in colorectal cancer (CRC). It highlights the role of the IL-34/MCSF-1R axis in controlling tumor-associated macrophages (TAMs) and promoting cancer resistance to chemotherapy and immunotherapy. The findings suggest that targeting IL-34/MCSF-1R could be a potential therapeutic intervention in CRC.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Josep Tarrago-Celada, Marta Cascante
Summary: The search for new therapeutic opportunities to target cancer metastasis is crucial for the improvement of cancer treatment. Metabolic adaptation is an important hallmark of cancer and metastasis, and targeting metabolic pathways represents a promising strategy to specifically target metastatic cells, especially in colorectal cancer metastasis. Expanding research in this field may lead to the development of new therapeutic strategies for metastatic colorectal cancer.
Review
Biochemistry & Molecular Biology
Reid Loveless, Yong Teng
Summary: WASF3 is a crucial regulator in promoting cancer cell invasion and metastasis, and targeting it at the transcription, protein stability, and phosphorylation levels holds promise for metastasis suppression regardless of the diverse genetic backgrounds associated with tumor development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hailang Zhou, Shu Huang, Changjiang Shao, Junwei Zou, Aijun Zhou, Jiufeng Yu, Chunfang Xu
Summary: miR-1266-3p, with lower expression in colon cancer, inhibits growth, metastasis, and EMT by targeting P4HA3, offering a novel target for diagnosis and treatment of colon cancer.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Oncology
Taohua Yue, Jichang Li, Jing Zhu, Shuai Zuo, Xin Wang, Yucun Liu, Jia Liu, Xiaoyun Liu, Pengyuan Wang, Shanwen Chen
Summary: Immunotherapy can be effective in treating cancer, but many colorectal cancer patients do not respond to it. This study shows that reducing H2S levels can help reverse the tumor-supportive functions and improve the efficacy of immunotherapy.
Article
Food Science & Technology
Yi-Shiou Chiou, Yi-Ming Lan, Pei-Sheng Lee, Qianyu Lin, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
Summary: This study identified a specific molecular mechanism that can prevent the progression and metastasis of colorectal cancer by regulating the interaction between tumor-associated macrophages and cancer cells. The results showed that piceatannol (PIC) effectively inhibited the aggressive features and stemness of cancer cells by restricting the polarization of M2-like macrophages and blocking the positive feedback loop of transforming growth factor beta 1 (TGF-beta 1) in the tumor microenvironment. In vivo experiments also demonstrated significant repression of tumor growth and lung metastases with the administration of PIC.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sana Iram, Safikur Rahman, Shahid Ali, Jihoe Kim
Summary: Epigallocatechin gallate inhibits the activation of plasminogen by binding to tetranectin, showing anticancer effects on CT-26 colon cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Lei Liu, Jianfeng Cui, Yajing Zhao, Xiaochen Liu, Lipeng Chen, Yangyang Xia, Yong Wang, Shouzhen Chen, Shuna Sun, Benkang Shi, Yongxin Zou
Summary: The study demonstrates that KDM6A promotes transcription of ARHGDIB by demethylating histone H3 lysine di/trimethylation, leading to inhibition of Rac1 and suppression of bladder cancer cell motility and invasiveness. Additionally, the direct binding of FOXA1 to the KDM6A promoter activates KDM6A and reduces metastatic potential in bladder cancer.
Article
Plant Sciences
Seung Ho Shin, Seoung Rak Lee, Eunjung Lee, Ki Hyun Kim, Sanguine Byun
JOURNAL OF NATURAL PRODUCTS
(2017)
Article
Food Science & Technology
Hee Yang, Sang Gwon Seo, Seung Ho Shin, Soyun Min, Min Jeong Kang, Ra Yoo, Jeong Yeon Kwon, Shuhua Yue, Kee Hong Kim, Ji-Xin Cheng, Jong Rhan Kim, Joon-Suk Park, Jong Hun Kim, Jung Han Yoon Park, Hyong Joo Lee, Ki Won Lee
MOLECULAR NUTRITION & FOOD RESEARCH
(2017)
Editorial Material
Medicine, General & Internal
Seung Ho Shin, Zigang Dong
Article
Medicine, General & Internal
Tatyana A. Zykova, Feng Zhu, Lei Wang, Haitao Li, Ruihua Bai, Do Young Lim, Ke Yao, Ann M. Bode, Zigang Dong
Article
Biochemistry & Molecular Biology
Eunmiri Roh, Mee-Hyun Lee, Tatyana A. Zykova, Feng Zhu, Janos Nadas, Hong-Gyum Kim, Ki Beom Bae, Yan Li, Yong Yeon Cho, Clara Curiel-Lewandrowski, Janine Einspahr, Sally E. Dickinson, Ann M. Bode, Zigang Dong
Article
Medicine, General & Internal
Simin Zhao, Ke Yao, Dan Li, Kangdong Liu, Guoguo Jin, Mingyang Yan, Qiong Wu, Hanyong Chen, Seung Ho Shin, Ruihua Bai, Gangcheng Wang, Ann M. Bode, Ziming Dong, Ping Guo, Zigang Dong
Article
Medicine, Research & Experimental
Ming-Yang Li, Lin-Ni Fan, Dong-Hui Han, Zhou Yu, Jing Ma, Yi-Xiong Liu, Pei-Feng Li, Dan-Hui Zhao, Jia Chai, Lei Jiang, Shi-Liang Li, Juan-Juan Xiao, Qiu-Hong Duan, Jing Ye, Mei Shi, Yong-Zhan Nie, Kai-Chun Wu, Dezhong Joshua Liao, Yu Shi, Yan Wang, Qing-Guo Yan, Shuang-Ping Guo, Xiu-Wu Bian, Feng Zhu, Jian Zhang, Zhe Wang
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Seung Ho Shin, Ji Su Lee, Jia-Min Zhang, Sungbin Choi, Zarko Boskovic, Ran Zhao, Mengqiu Song, Rui Wang, Jie Tian, Mee-Hyun Lee, Jae Hwan Kim, Minju Jeong, Jung Hyun Lee, Michael Petukhov, Sam W. Lee, Sang Gyun Kim, Lee Zou, Sanguine Byun
Review
Biochemistry & Molecular Biology
Dongyup Hahn, Seung Ho Shin, Jong-Sup Bae
Article
Medicine, Research & Experimental
Xiaoyu Chang, Tianshun Zhang, Qiushi Wang, Moeez Ghani Rathore, Kanamata Reddy, Hanyong Chen, Seung Ho Shin, Wei-ya Ma, Ann M. Bode, Zigang Dong
Article
Medicine, Research & Experimental
Hui Liu, Seung Ho Shin, Hanyong Chen, Tingting Liu, Zhi Li, Yamei Hu, Fangfang Liu, Chengjuan Zhang, Doon Jun Kim, Kangdong Liu, Zigang Dong
Article
Cell Biology
Yang Fu, Ge Yang, Peipei Xue, Luwei Guo, Yuhan Yin, Zhiqiang Ye, Sanfei Peng, Yanru Qin, Qiuhong Duan, Feng Zhu
CELL DEATH DISCOVERY
(2018)
Review
Oncology
Seung Ho Shin, Ann M. Bode, Zigang Dong
NPJ PRECISION ONCOLOGY
(2017)