Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance

Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of Staphylococcus aureus towards Polymyxins

(2017) Martin Vestergaard et al.   mBio

Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011–2014

(2016) Lindsey M. Weiner et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Dysregulation ofmprFanddltABCDexpression among daptomycin-non-susceptible MRSA clinical isolates

(2016) Arnold S. Bayer et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains

(2016) Anna Müller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid somersaults: Uncovering the mechanisms of protein-mediated lipid flipping

(2016) Thomas Günther Pomorski et al.   PROGRESS IN LIPID RESEARCH

Mechanism of Action and Resistance to Daptomycin in Staphylococcus aureus and Enterococci

(2016) William R. Miller et al.   Cold Spring Harbor Perspectives in Medicine

Mechanisms of drug resistance: daptomycin resistance

(2015) Truc T. Tran et al.   Annals of the New York Academy of Sciences

Frequency and Distribution of Single-Nucleotide Polymorphisms withinmprFin Methicillin-Resistant Staphylococcus aureus Clinical Isolates and Their Role in Cross-Resistance to Daptomycin and Host Defense Antimicrobial Peptides

(2015) Arnold S. Bayer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Lipid-Modifying Multiple Peptide Resistance Factor Is an Oligomer Consisting of Distinct Interacting Synthase and Flippase Subunits

(2015) Christoph M. Ernst et al.   mBio

Heterogeneity ofmprFSequences in Methicillin-Resistant Staphylococcus aureus Clinical Isolates: Role in Cross-Resistance between Daptomycin and Host Defense Antimicrobial Peptides

(2014) Arnold S. Bayer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

Phenotypic and Genotypic Characterization of Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Strains: Relative Roles of mprF and dlt Operons

(2014) Nagendra N. Mishra et al.   PLoS One

Causal Role of Single Nucleotide Polymorphisms within themprFGene of Staphylococcus aureus in Daptomycin Resistance

(2013) Soo-Jin Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Revised mechanism of D-alanine incorporation into cell wall polymers in Gram-positive bacteria

(2013) N. T. Reichmann et al.   MICROBIOLOGY-SGM

Emergence of Daptomycin Resistance in Daptomycin-Naïve Rabbits with Methicillin-Resistant Staphylococcus aureus Prosthetic Joint Infection Is Associated with Resistance to Host Defense Cationic Peptides and mprF Polymorphisms

(2013) Nagendra N. Mishra et al.   PLoS One

Mechanisms of daptomycin resistance inStaphylococcus aureus: role of the cell membrane and cell wall

(2012) Arnold S. Bayer et al.   Annals of the New York Academy of Sciences

Alanyl-Phosphatidylglycerol and Lysyl-Phosphatidylglycerol Are Translocated by the Same MprF Flippases and Have Similar Capacities To Protect against the Antibiotic Daptomycin in Staphylococcus aureus

(2012) Christoph J. Slavetinsky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

LC-MS/MS characterization of phospholipid content in daptomycin-susceptible and -resistant isolates ofStaphylococcus aureuswith mutations inmprF

(2012) Aileen Rubio et al.   MOLECULAR MEMBRANE BIOLOGY

Whole Genome Characterization of the Mechanisms of Daptomycin Resistance in Clinical and Laboratory Derived Isolates of Staphylococcus aureus

(2012) Anton Y. Peleg et al.   PLoS One

VraSR Two-Component Regulatory System Contributes tomprF-Mediated Decreased Susceptibility to Daptomycin inIn Vivo-Selected Clinical Strains of Methicillin-Resistant Staphylococcus aureus

(2011) Shrenik Mehta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Broad-spectrum antimicrobial peptide resistance by MprF-mediated aminoacylation and flipping of phospholipids

(2011) Christoph M. Ernst et al.   MOLECULAR MICROBIOLOGY

Current and novel antibiotics against resistant Gram-positive bacteria

(2010) Federico Perez   Infection and Drug Resistance

The Lipopeptide Antibiotic Friulimicin B Inhibits Cell Wall Biosynthesis through Complex Formation with Bactoprenol Phosphate

(2009) T. Schneider et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Daptomycin versus Friulimicin B: In-Depth Profiling of Bacillus subtilis Cell Envelope Stress Responses

(2009) T. Wecke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Analysis of Cell Membrane Characteristics of In Vitro-Selected Daptomycin-Resistant Strains of Methicillin-Resistant Staphylococcus aureus

(2009) N. N. Mishra et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lantibiotics: Mode of Action, Biosynthesis and Bioengineering

(2009) G. Bierbaum et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine

(2009) N. Y. Yount et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Bacterial Defensin Resistance Protein MprF Consists of Separable Domains for Lipid Lysinylation and Antimicrobial Peptide Repulsion

(2009) Christoph M. Ernst et al.   PLoS Pathogens

The GraRS regulatory system controls Staphylococcus aureus susceptibility to antimicrobial host defenses

(2008) Dirk Kraus et al.   BMC MICROBIOLOGY

Daptomycin non-susceptible meticillin-resistant Staphylococcus aureus USA 300 isolate

(2008) M. H. Murthy et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions

(2008) Christopher Weidenmaier et al.   NATURE REVIEWS MICROBIOLOGY