☆ 4.7 Article

Daptomycin versus Friulimicin B: In-Depth Profiling of Bacillus subtilis Cell Envelope Stress Responses

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)

期刊

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

卷 53, 期 4, 页码 1619-1623

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AMER SOC MICROBIOLOGY

DOI: 10.1128/AAC.01046-08

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Microbiology Pharmacology & Pharmacy

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The related lipo(depsi)peptide antibiotics daptomycin and friulimicin B show great potential in the treatment of multiply resistant gram-positive pathogens. Applying genome-wide in-depth expression profiling, we compared the respective stress responses of Bacillus subtilis. Both antibiotics target envelope integrity, based on the strong induction of extracytoplasmic function sigma factor-dependent gene expression. The cell envelope stress-sensing two-component system LiaRS is exclusively and strongly induced by daptomycin, indicative of different mechanisms of action in the two compounds.

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