Review
Medicine, General & Internal
Erlangga Yusuf, Hannelore I. Bax, Nelianne J. Verkaik, Mireille van Westreenen
Summary: Infections in the ICU are often caused by Gram-negative bacteria, which can become resistant to traditional antibiotics, limiting treatment options. In recent years, FDA has approved new antibiotics with predominant activities against Gram-negative bacteria, providing more choices for treatment in specific circumstances.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Min Li, Jialin Li, Jingyi Li, Jie Zhang, Yuqing Zhao, Wenying Li, Yunfei Zhang, Jinrong Hu, Xiaolin Xie, Dezhu Zhang, Han Li, Qianqian Zhao, Hong Gao, Chengyuan Liang
Summary: The emergence of drug-resistant strains presents a challenge for traditional antibiotics. In this study, a collection of pleuromutilin aromatic acrylate derivatives were designed and synthesized to explore novel antibacterial drugs. Most of these derivatives displayed excellent antibacterial activity against both Gram-positive and Gram-negative bacteria, with 5g showing the strongest activity and potential as a clinical treatment for drug-resistant bacterial infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Microbiology
Joakim Bjerketorp, Jolanta J. Levenfors, Christina Nord, Bengt Guss, Bo Oberg, Anders Broberg
Summary: Twenty-eight multidrug-resistant bacterial strains closely related or identical to Pedobacter cryoconitis, Pedobacter lusitanus, and Pedobacter steynii were isolated from soil samples by selection for multidrug-resistance. These strains produced a wide array of novel compounds, with Pedobacter strain UP508 producing isopedopeptins and other strains producing different peptides.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Infectious Diseases
Claire Overly Cottom, Robert Stephenson, Lindsey Wilson, Nicholas Noinaj
Summary: The emergence of multidrug resistance in bacterial pathogens poses a global threat to human health, but the discovery of new antibiotics has not kept pace with this alarming trend. Recent approaches to antibiotic discovery have expanded to target essential surface receptors and protein complexes, including the beta-barrel assembly machinery (BAM) responsible for the biogenesis of outer membrane proteins in Gram-negative bacteria. In this review, we highlight the importance of BAM as a promising therapeutic target and discuss recent studies on compounds and vaccines targeting BAM across various bacteria, sparking ongoing research and interest in BAM for combating multidrug resistance.
Article
Chemistry, Physical
Diana Guadalupe Tellez-de-Jesus, N. S. Flores-Lopez, J. A. Cervantes-Chavez, A. R. Hernandez-Martinez
Summary: Plant extracts have been found to enhance the antibacterial activity of conventional antibiotics, which can be used to synthesize nanoparticles for producing more efficient antibiotics. A study on the medicinal plant Argemone mexicana L. revealed that its extract can be used to synthesize gold and silver nanoparticles with excellent performance against antibiotic-resistant bacteria.
SURFACES AND INTERFACES
(2021)
Article
Microbiology
Junliang Zhang, Xiaoyan Liang, Shiling Zhang, Zhiman Song, Changyun Wang, Ying Xu
Summary: Pathogenic bacterial biofilms are difficult to eradicate and can develop antibiotic resistance. MaiA, a compound isolated from a rare actinomycete strain, shows broad-spectrum anti-biofilm activities against Gram-negative bacteria and can enhance the efficacy of certain antibiotics, potentially serving as an effective agent to prevent biofilm formation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Arianne Lovey, Mila Krel, Allen Borchardt, Thomas Brady, Jason N. Cole, Quyen-Quyen Do, Joanne Fortier, Grayson Hough, Wanlong Jiang, Alain Noncovich, Les Tari, Qiping Zhao, James M. Balkovec, Yanan Zhao, David S. Perlin
Summary: ADCs have the potential to bind strongly to drug-resistant G- pathogens, regardless of lipopolysaccharide modifications, indicating a promising treatment alternative in infections caused by drug-resistant G- bacteria.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Yuvaneswary Veloo, Syahidiah S. A. Thahir, Sakshaleni Rajendiran, Lim K. Hock, Norazah Ahmad, Vickneshwaran Muthu, Rafiza Shaharudin
Summary: The indiscriminate use of antibiotics in poultry farming has led to the emergence of antibiotic-resistant bacteria in poultry products and the surrounding environment. This study found high rates of multidrug-resistant Gram-negative bacteria in the environment of poultry farms, with some strains exhibiting resistance to multiple antibiotics. The presence of these bacteria poses a significant threat to the effectiveness of available antibiotics in treating infectious diseases. Efforts to regulate antibiotic use and conduct research on One Health issues are necessary to combat and prevent the spread of antibiotic-resistant bacteria.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biology
Hani Mohammed Ali
Summary: Antibiotics are drugs used to treat bacterial infections, but antibiotic-resistant bacteria have become a major concern. This study utilized in-silico docking screening to identify a potential natural compound that can overcome antibiotic resistance in bacteria.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Wanqing Cheng, Ting Xu, Liping Cui, Zihan Xue, Jifeng Liu, Ruige Yang, Shangshang Qin, Yong Guo
Summary: Infections caused by multidrug-resistant (MDR) bacteria are increasing worldwide, and novel antimicrobials are urgently needed. In this study, a class of amphiphilic xanthohumol derivatives were synthesized and molecule IV15 showed remarkable antibacterial effects, rapid bactericidal properties, low toxicity, good plasma stability, and reduced bacterial resistance. Mechanistic studies revealed that IV15 disrupted bacterial cell membranes, leading to bacterial death by increasing reactive oxygen species and causing leakage of proteins and DNA. Importantly, IV15 exhibited superior in vivo anti-MRSA efficacy compared to vancomycin.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Kefurong Deng, Yachao Li, Xiaoyu Liang, Cheng Shen, Zenan Zeng, Xianghui Xu
Summary: This study developed virus-inspired nanodrugs for high-efficiency antibiotic delivery and enhanced antibacterial effects, demonstrating their potential application in antibacterial treatment.
CHINESE CHEMICAL LETTERS
(2022)
Article
Microbiology
Michael Marner, Laura Kolberg, Julia Horst, Nils Boehringer, Johannes Huebner, I. Dewa M. Kresna, Yang Liu, Ute Mettal, Lei Wang, Melanie Meyer-Buehn, Sanja Mihajlovic, Matthias Kappler, Till F. Schaeberle, Ulrich von Both
Summary: Antimicrobial resistance poses an increasing threat to healthcare. To address the need for innovative treatment of respiratory infections, antibiotics with new modes of action need to be developed. This study generated the antibiogram of clinical isolates from cystic fibrosis patients and identified bicyclic heptapeptides that inhibit the outer membrane protein BamA, showing strong activity against multidrug-resistant strains.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Aliya Fazal, Sajida Ara, Muhammad Tayab Ishaq, Kalsoom Sughra
Summary: The study focuses on the green synthesis of copper oxide nanoparticles using vegetable peels, with an ecofriendly approach and low fabrication temperature. It also explores the antibacterial efficacy of the nanoparticles, showing a more significant biocidal effect on Gram-negative bacteria compared to Gram-positive bacteria. The research highlights the potential of utilizing biowaste for the production of useful products.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2022)
Article
Microbiology
Edwin Esau Hernandez-Arvizu, Teresa Monserrat Silis-Moreno, Jose Alejandro Garcia-Arredondo, Angelina Rodriguez-Torres, Jose Antonio Cervantes-Chavez, Juan Mosqueda
Summary: Anti-microbial peptides play a crucial role in the defense mechanisms of various organisms. In this study, a cathelicidin-like peptide called Aquiluscidin was identified for the first time in Crotalus aquilus, exhibiting remarkable inhibitory activity against multiple bacteria. It has the potential to be a candidate for further antimicrobial research.
Review
Immunology
Flora Cruz-Lopez, Adrian Martinez-Melendez, Rayo Morfin-Otero, Eduardo Rodriguez-Noriega, Hector J. Maldonado-Garza, Elvira Garza-Gonzalez
Summary: Infections caused by Gram-negative multi-drug resistant (MDR) bacterial species are difficult to treat due to widespread antibiotic resistance. New antibiotics and combinations with existing drugs have shown potential in treating these infections, but there are reports of resistance to these treatments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)