Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer’s Disease

Age-Dependent Changes in the Sarkosyl-Insoluble Proteome of APPSWE/PS1ΔE9 Transgenic Mice Implicate Dysfunctional Mitochondria in the Pathogenesis of Alzheimer’s Disease

(2018) Camilla Thygesen et al.   JOURNAL OF ALZHEIMERS DISEASE

ApoE facilitates the microglial response to amyloid plaque pathology

(2018) Jason D. Ulrich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer’s Disease Brain: A Review

(2018) Xinhua Zhan et al.   Frontiers in Aging Neuroscience

Increased AβPP Processing in Familial Danish Dementia Patients

(2018) Shuji Matsuda et al.   JOURNAL OF ALZHEIMERS DISEASE

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis

(2017) Euan R. O. Allan et al.   Journal of Neuroinflammation

Peripheral inflammatory markers in Alzheimer’s disease: a systematic review and meta-analysis of 175 studies

(2017) Ka Sing P Lai et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyloid and intracellular accumulation of BRI 2

(2017) Holly J. Garringer et al.   NEUROBIOLOGY OF AGING

Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation

(2017) Anja Pišlar et al.   NEUROPHARMACOLOGY

Role of clusterin in the brain vascular clearance of amyloid-β

(2017) Amy R. Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Oxidative Stress in the Progression of Alzheimer's Disease

(2017) Rukhsana Sultana et al.   JOURNAL OF ALZHEIMERS DISEASE

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

(2016) Marc Suárez‐Calvet et al.   EMBO Molecular Medicine

Targeting neuroinflammation in Alzheimer’s disease: evidence for NSAIDs and novel therapeutics

(2016) William James Deardorff et al.   Expert Review of Neurotherapeutics

Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling

(2016) Andrea Crotti et al.   IMMUNITY

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

(2016) Stefan J. Kempf et al.   Oncotarget

Targeting neuroinflammation in Alzheimer’s disease: evidence for NSAIDs and novel therapeutics

(2016) William James Deardorff et al.   Expert Review of Neurotherapeutics

Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice

(2015) Alicia A. Babcock et al.   BRAIN BEHAVIOR AND IMMUNITY

All-trans-retinoic Acid ReducesBACE1Expression under Inflammatory Conditions via Modulation of Nuclear Factor κB (NFκB) Signaling

(2015) Ruishan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation

(2015) Stefan J Kempf et al.   Molecular Neurodegeneration

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

(2014) Deborah Doens et al.   Journal of Neuroinflammation

Age-associated dysregulation of microglial activation is coupled with enhanced blood-brain barrier permeability and pathology in APP/PS1 mice

(2014) Aedín M. Minogue et al.   NEUROBIOLOGY OF AGING

Neuroprotective role of γ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X

(2013) Anja Hafner et al.   AGING CELL

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Microglial Phenotype and Adaptation

(2013) B. J. L. Eggen et al.   Journal of Neuroimmune Pharmacology

Assessment and Improvement of Statistical Tools for Comparative Proteomics Analysis of Sparse Data Sets with Few Experimental Replicates

(2013) Veit Schwämmle et al.   JOURNAL OF PROTEOME RESEARCH

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

What does complement do in Alzheimer’s disease? Old molecules with new insights

(2013) Yong Shen et al.   Translational Neurodegeneration

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Morphological features of microglial cells in the hippocampal dentate gyrus of Gunn rat: a possible schizophrenia animal model

(2012) Kristian Liaury et al.   Journal of Neuroinflammation

The Proteomics Identifications (PRIDE) database and associated tools: status in 2013

(2012) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity

(2011) Grietje Krabbe et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Serum levels of S100B and NSE proteins in Alzheimer's disease patients

(2010) Márcia L Chaves et al.   Journal of Neuroinflammation

Mass spectrometry in high-throughput proteomics: ready for the big time

(2010) Tommy Nilsson et al.   NATURE METHODS

Retinoid X receptor   controls innate inflammatory responses through the up-regulation of chemokine expression

(2010) V. Nunez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis

(2009) S. Mandrekar et al.   JOURNAL OF NEUROSCIENCE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles

(2009) Shuji Matsuda et al.   NEUROBIOLOGY OF AGING

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

(2008) Stefanie Frank et al.   GLIA

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Hydrophilic Interaction Chromatography Reduces the Complexity of the Phosphoproteome and Improves Global Phosphopeptide Isolation and Detection

(2008) Dean E. McNulty et al.   MOLECULAR & CELLULAR PROTEOMICS

Synaptic contact number and size in stratum radiatum CA1 of APP/PS1ΔE9 transgenic mice

(2008) Mark J. West et al.   NEUROBIOLOGY OF AGING