Post-transcriptional control of miRNA biogenesis

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Non-canonical functions of microRNA pathway enzymes - Drosha, DGCR8, Dicer and Ago proteins

(2018) Sheng Kai Pong et al.   FEBS LETTERS

Regulation of primary microRNA processing

(2018) Antoine Creugny et al.   FEBS LETTERS

Noncoding RNAs in disease

(2018) Evangelia Lekka et al.   FEBS LETTERS

microRNA single polynucleotide polymorphism influences on microRNA biogenesis and mRNA target specificity

(2018) Jarosław Króliczewski et al.   GENE

Systematic Discovery of RNA Binding Proteins that Regulate MicroRNA Levels

(2018) Julia K. Nussbacher et al.   MOLECULAR CELL

Microprocessor depends on hemin to recognize the apical loop of primary microRNA

(2018) Tuan Anh Nguyen et al.   NUCLEIC ACIDS RESEARCH

SRSF3 recruits DROSHA to the basal junction of primary microRNAs

(2018) Kijun Kim et al.   RNA

Splicing factors as regulators of miRNA biogenesis – links to human disease

(2018) Madara Ratnadiwakara et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1

(2018) Hamed Kooshapur et al.   Nature Communications

Modulation of oncogenic miRNA biogenesis using functionalized polyamines

(2018) Cathy Staedel et al.   Scientific Reports

Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28

(2018) Longfei Wang et al.   Cell Reports

Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation

(2017) Christine Roden et al.   GENOME RESEARCH

Oleic Acid Induces MiR-7 Processing through Remodeling of Pri-MiR-7/Protein Complex

(2017) Santosh Kumar et al.   JOURNAL OF MOLECULAR BIOLOGY

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis

(2017) Thomas Treiber et al.   MOLECULAR CELL

NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing

(2017) Li Jiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding

(2017) Philip Knuckles et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells

(2017) Huiwu Ouyang et al.   NUCLEIC ACIDS RESEARCH

Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs

(2017) Alexander C. Partin et al.   Nature Communications

Genetic variation and RNA structure regulate microRNA biogenesis

(2017) Noemi Fernandez et al.   Nature Communications

NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing

(2017) Li Jiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding

(2017) Philip Knuckles et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Small-Molecule Inhibitor of Lin28

(2016) Martina Roos et al.   ACS Chemical Biology

RISC assembly: Coordination between small RNAs and Argonaute proteins

(2016) Hotaka Kobayashi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Structure of Human DROSHA

(2016) S. Chul Kwon et al.   CELL

Suppression of MicroRNA-7 (miR-7) Biogenesis by Nuclear Factor 90-Nuclear Factor 45 Complex (NF90-NF45) Controls Cell Proliferation in Hepatocellular Carcinoma

(2016) Takuma Higuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H19Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR

(2016) Tongtong Zou et al.   MOLECULAR AND CELLULAR BIOLOGY

HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing

(2016) Haoming Liu et al.   MOLECULAR CELL

A network-biology perspective of microRNA function and dysfunction in cancer

(2016) Cameron P. Bracken et al.   NATURE REVIEWS GENETICS

Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer

(2016) Yu Chen et al.   NUCLEIC ACIDS RESEARCH

Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively

(2016) Jakub Stanislaw Nowak et al.   RNA

Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors

(2015) Amy L. Walz et al.   CANCER CELL

Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors

(2015) Jenny Wegert et al.   CANCER CELL

Functional Anatomy of the Human Microprocessor

(2015) Tuan Anh Nguyen et al.   CELL

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma

(2015) L.-F. Zhang et al.   EMBO JOURNAL

DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs

(2015) Sara Macias et al.   MOLECULAR CELL

The Menu of Features that Define Primary MicroRNAs and Enable De Novo Design of MicroRNA Genes

(2015) Wenwen Fang et al.   MOLECULAR CELL

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

(2015) Ximena Paez-Colasante et al.   Nature Reviews Neurology

Genome-wide analysis of YB-1-RNA interactions reveals a novel role of YB-1 in miRNA processing in glioblastoma multiforme

(2015) Shuai-Lai Wu et al.   NUCLEIC ACIDS RESEARCH

Nucleotide sequence of miRNA precursor contributes to cleavage site selection by Dicer

(2015) Julia Starega-Roslan et al.   NUCLEIC ACIDS RESEARCH

Bioinformatic tools for microRNA dissection

(2015) Most Mauluda Akhtar et al.   NUCLEIC ACIDS RESEARCH

Dysregulation of microRNA biogenesis and gene silencing in cancer

(2015) Akiko Hata et al.   Science Signaling

The Functions of MicroRNAs: mRNA Decay and Translational Repression

(2015) Hiro-oki Iwakawa et al.   TRENDS IN CELL BIOLOGY

A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture

(2015) Jacek Krol et al.   Nature Communications

Dysregulation of microRNA biogenesis and gene silencing in cancer

(2015) Akiko Hata et al.   Science Signaling

Human genetic variation and its effect on miRNA biogenesis, activity and function

(2014) Daniel R. Hogg et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

(2014) Masaki Mori et al.   CELL

Regulation of pri-miRNA Processing by a Long Noncoding RNA Transcribed from an Ultraconserved Region

(2014) Julia Liz et al.   MOLECULAR CELL

A Feedforward Regulatory Loop between HuR and the Long Noncoding RNA linc-MD1 Controls Early Phases of Myogenesis

(2014) Ivano Legnini et al.   MOLECULAR CELL

Sequence-based design of bioactive small molecules that target precursor microRNAs

(2014) Sai Pradeep Velagapudi et al.   Nature Chemical Biology

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rbfox3 controls the biogenesis of a subset of microRNAs

(2014) Kee K Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells

(2014) Martina Roos et al.   NUCLEIC ACIDS RESEARCH

Processing of microRNA primary transcripts requires heme in mammalian cells

(2014) Sara H. Weitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of a peptoid ligand with the apical loop of pri-miR-21 inhibits cleavage by Drosha

(2014) J. P. Diaz et al.   RNA

miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure

(2014) H. Sperber et al.   RNA

Lin28a regulates neuronal differentiation and controls miR-9 production

(2014) Jakub S. Nowak et al.   Nature Communications

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

(2014) Dinesh Rakheja et al.   Nature Communications

The DGCR8 RNA-Binding Heme Domain Recognizes Primary MicroRNAs by Clamping the Hairpin

(2014) Jen Quick-Cleveland et al.   Cell Reports

Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation

(2014) Nila Roy Choudhury et al.   Cell Reports

Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite

(2014) Carina C Clingman et al.   eLife

Terminal loop-mediated regulation of miRNA biogenesis: selectivity and mechanisms

(2013) Virginia Castilla-Llorente et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cellular functions of the microprocessor

(2013) Sara Macias et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

AC1MMYR2, an Inhibitor of Dicer-Mediated Biogenesis of Oncomir miR-21, Reverses Epithelial-Mesenchymal Transition and Suppresses Tumor Growth and Progression

(2013) Z. Shi et al.   CANCER RESEARCH

Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing

(2013) Vincent C. Auyeung et al.   CELL

A multifunctional protein EWS regulates the expression of Drosha and microRNAs

(2013) K Y Kim et al.   CELL DEATH AND DIFFERENTIATION

Tissue-specific control of brain-enriched miR-7 biogenesis

(2013) N. R. Choudhury et al.   GENES & DEVELOPMENT

hnRNP A1: The Swiss Army Knife of Gene Expression

(2013) Jacques Jean-Philippe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BiallelicDICER1mutations occur in Wilms tumours

(2013) MK Wu et al.   JOURNAL OF PATHOLOGY

TDP-43 Regulates the Microprocessor Complex Activity During In Vitro Neuronal Differentiation

(2013) Valerio Di Carlo et al.   MOLECULAR NEUROBIOLOGY

A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28–let-7 pathway

(2013) Hao-Ming Chang et al.   NATURE

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

The Microprocessor controls the activity of mammalian retrotransposons

(2013) Sara R Heras et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs

(2013) D. Ustianenko et al.   RNA

Neuronal dark matter: the emerging role of microRNAs in neurodegeneration

(2013) Emily F. Goodall et al.   Frontiers in Cellular Neuroscience

Terminal loop-mediated control of microRNA biogenesis

(2012) Nila Roy Choudhury et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Processing of plant microRNA precursors

(2012) N. G. Bologna et al.   Briefings in Functional Genomics

The MicroRNA-17-92 Family of MicroRNA Clusters in Development and Disease

(2012) Carla P. Concepcion et al.   CANCER JOURNAL

Human RNA Methyltransferase BCDIN3D Regulates MicroRNA Processing

(2012) Blerta Xhemalce et al.   CELL

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals

(2012) Ryuya Fukunaga et al.   CELL

MicroRNA biogenesis: regulating the regulators

(2012) Emily F. Finnegan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment

(2012) Mariangela Morlando et al.   EMBO JOURNAL

BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex

(2012) Shinji Kawai et al.   JOURNAL OF CELL BIOLOGY

Biogenesis, functions and fate of plant microRNAs

(2012) Afsar Raza Naqvi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs

(2012) Philip Knuckles et al.   NATURE NEUROSCIENCE

DGCR8 HITS-CLIP reveals novel functions for the Microprocessor

(2012) Sara Macias et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Systematic screens of proteins binding to synthetic microRNA precursors

(2012) Harry Towbin et al.   NUCLEIC ACIDS RESEARCH

The Lin28 cold-shock domain remodels pre-let-7 microRNA

(2012) Florian Mayr et al.   NUCLEIC ACIDS RESEARCH

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

(2012) Y. Kawahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A LIN28-Dependent Structural Change in pre-let-7g Directly Inhibits Dicer Processing

(2011) Helen L. Lightfoot et al.   BIOCHEMISTRY

Molecular Basis for Interaction of let-7 MicroRNAs with Lin28

(2011) Yunsun Nam et al.   CELL

Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR

(2011) Svetlana Lebedeva et al.   MOLECULAR CELL

Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28

(2011) Fionna E Loughlin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy

(2011) Frédérique Rau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recurrent SomaticDICER1Mutations in Nonepithelial Ovarian Cancers

(2011) Alireza Heravi-Moussavi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vive la différence: biogenesis and evolution of microRNAs in plants and animals

(2011) Michael J Axtell et al.   GENOME BIOLOGY

An Aptamer Targeting the Apical-Loop Domain Modulates pri-miRNA Processing

(2010) Christina E. Lünse et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

Canonical and alternate functions of the microRNA biogenesis machinery

(2010) M. M. W. Chong et al.   GENES & DEVELOPMENT

Posttranscriptional Regulation of MicroRNA Biogenesis in Animals

(2010) Haruhiko Siomi et al.   MOLECULAR CELL

Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes

(2010) Shintaro Iwasaki et al.   MOLECULAR CELL

A Splicing-Independent Function of SF2/ASF in MicroRNA Processing

(2010) Han Wu et al.   MOLECULAR CELL

Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha

(2010) Brandi N. Davis et al.   MOLECULAR CELL

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

A direct role for Hsp90 in pre-RISC formation in Drosophila

(2010) Tomohiro Miyoshi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis

(2010) Gracjan Michlewski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The terminal loop region controls microRNA processing by Drosha and Dicer

(2010) X. Zhang et al.   NUCLEIC ACIDS RESEARCH

Posttranscriptional Crossregulation between Drosha and DGCR8

(2009) Jinju Han et al.   CELL

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

Editing independent effects of ADARs on the miRNA/siRNA pathways

(2009) Bret S E Heale et al.   EMBO JOURNAL

Modulation of microRNA processing by p53

(2009) Hiroshi I. Suzuki et al.   NATURE

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

(2009) Michele Trabucchi et al.   NATURE

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

Cell-cell contact globally activates microRNA biogenesis

(2009) H.-W. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide identification of targets of the drosha-pasha/DGCR8 complex

(2009) S. Kadener et al.   RNA

Post-transcriptional control of DGCR8 expression by the Microprocessor

(2009) R. Triboulet et al.   RNA

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

(2008) B. Kefas et al.   CANCER RESEARCH

Novel genetic variants in microRNA genes and familial breast cancer

(2008) Jie Shen et al.   INTERNATIONAL JOURNAL OF CANCER

Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28

(2008) Elena Piskounova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Posttranscriptional Regulation of miRNAs Harboring Conserved Terminal Loops

(2008) Gracjan Michlewski et al.   MOLECULAR CELL

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

Primary microRNA transcripts are processed co-transcriptionally

(2008) Mariangela Morlando et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

(2008) M. A. Newman et al.   RNA

Selective Blockade of MicroRNA Processing by Lin28

(2008) S. R. Viswanathan et al.   SCIENCE