Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation

Structure of Human DROSHA

(2016) S. Chul Kwon et al.   CELL

A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions

(2016) Jijun Cheng et al.   Nature Communications

Functional Anatomy of the Human Microprocessor

(2015) Tuan Anh Nguyen et al.   CELL

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

Genome-wide annotation of microRNA primary transcript structures reveals novel regulatory mechanisms

(2015) Tsung-Cheng Chang et al.   GENOME RESEARCH

The Menu of Features that Define Primary MicroRNAs and Enable De Novo Design of MicroRNA Genes

(2015) Wenwen Fang et al.   MOLECULAR CELL

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

Characterization of the mammalian miRNA turnover landscape

(2015) Yanwen Guo et al.   NUCLEIC ACIDS RESEARCH

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

(2014) Masaki Mori et al.   CELL

MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex

(2014) Tian-Lin Cheng et al.   DEVELOPMENTAL CELL

Processing of microRNA primary transcripts requires heme in mammalian cells

(2014) Sara H. Weitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Derivation and characterization of Dicer- and microRNA-deficient human cells

(2014) H. P. Bogerd et al.   RNA

Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing

(2013) Vincent C. Auyeung et al.   CELL

TDP-43 Regulates the Microprocessor Complex Activity During In Vitro Neuronal Differentiation

(2013) Valerio Di Carlo et al.   MOLECULAR NEUROBIOLOGY

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Lower and upper stem-single-stranded RNA junctions together determine the Drosha cleavage site

(2013) H. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA involvement in human cancer

(2012) M. V. Iorio et al.   CARCINOGENESIS

Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8

(2012) Taeko Wada et al.   EMBO REPORTS

DGCR8 HITS-CLIP reveals novel functions for the Microprocessor

(2012) Sara Macias et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

(2012) Y. Kawahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms

(2012) S. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An In Vivo Functional Screen Uncovers miR-150-Mediated Regulation of Hematopoietic Injury Response

(2012) Brian D. Adams et al.   Cell Reports

Molecular Basis for Interaction of let-7 MicroRNAs with Lin28

(2011) Yunsun Nam et al.   CELL

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

A novel mutation within the MIR96 gene causes non-syndromic inherited hearing loss in an Italian family by altering pre-miRNA processing

(2011) Giulia Soldà et al.   HUMAN MOLECULAR GENETICS

Glycogen Synthase Kinase 3 Beta (GSK3β) Phosphorylates the RNAase III Enzyme Drosha at S300 and S302

(2011) Xiaoli Tang et al.   PLoS One

miRNAs in human cancer

(2010) Thalia A Farazi et al.   JOURNAL OF PATHOLOGY

Diverse Endonucleolytic Cleavage Sites in the Mammalian Transcriptome Depend upon MicroRNAs, Drosha, and Additional Nucleases

(2010) Fedor V. Karginov et al.   MOLECULAR CELL

Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha

(2010) Brandi N. Davis et al.   MOLECULAR CELL

Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling

(2009) Zain Paroo et al.   CELL

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

(2009) Michele Trabucchi et al.   NATURE

MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors

(2008) Jun Lu et al.   DEVELOPMENTAL CELL

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

The Vienna RNA Websuite

(2008) A. R. Gruber et al.   NUCLEIC ACIDS RESEARCH

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

(2008) M. A. Newman et al.   RNA

Selective Blockade of MicroRNA Processing by Lin28

(2008) S. R. Viswanathan et al.   SCIENCE